Metabolomics in Neurological and Neurodegenerative Diseases
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 3372
Special Issue Editor
Interests: metabolomics; lipidomics; brain imaging; multi-omic intergration; brain disease biomarkers
Special Issue Information
Dear Colleagues,
The study of metabolomics in the context of brain disease and development is leading to a greater understanding of disease pathology. These metabolites and lipids not only provide diagnostic and prognostic information but can also provide insight into the mechanism of the disease. Due to the difficulty with sampling tissue directly from the brain and to some extent obtaining cerebral spinal fluid, a challenge that remains is to understand the source of variation in metabolites observed in blood when looking at circulating metabolite markers. However, there is also clear evidence that there are peripheral responses to brain injury that can have defined patterns of metabolite changes in the circulation. Understanding this relationship is key to unpacking the disease pathologies. Combining metabolomics data with other datasets, such as magnetic resonance imaging or positron emission tomography data, represents a promising method for understanding this relationship. This Special Issue aims to highlight the use of metabolomics and lipidomics in neurological and neurodegenerative diseases. It will not only be focused on biomarkers for these diseases but also understanding the disease pathology. We welcome original research papers and review articles on any aspect of brain disease or injury.
Dr. Alex Dickens
Guest Editor
Manuscript Submission Information
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Keywords
- neurological disease
- neurodegenerative disease
- polar metabolites
- lipids
- brain imaging
- biomarkers
- data integration
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