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Metabolites
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Metabolic and Functional Disorders of Essential Metals and Vitamin D
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Metabolic and Functional Disorders of Essential Metals and Vitamin D

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 7670

Special Issue Editors

Prof. Dr. Lucia Fatima Campos Pedrosa

E-Mail Website
Guest Editor
Department of Nutrition, Federal University of Rio Grande do Norte, Natal 59.078-900, RN, Brazil
Interests: vitamin D; selenium; zinc; copper; diabetes; metabolic syndrome; food consumption; metabolomics
Prof. Dr. Karine Cavalcanti Maurício De Sena-Evangelista

E-Mail Website
Guest Editor
Department of Nutrition, Federal University of Rio Grande do Norte, Natal 59078-900, RN, Brazil
Interests: zinc; selenium; copper; vitamina D; diabetes; obesity; metabolic syndrome; cardiovascular disease; heart failure; food consumption
Dr. Flávia Fioruci Bezerra

E-Mail Website
Guest Editor
Institute of Nutrition, Rio de Janeiro State University, Rio de Janeiro 20550-900, RJ, Brazil
Interests: micronutrients; bone health; body composition; gene-diet interactions

Special Issue Information

Dear Colleagues,

Essential metals are present in human tissues and, in conditions of total absence in our organism, caise irreversible and severe damage to vital functions. Its deficiency can be normalized by the appropriate supplementation of the element. Among these elements, calcium, magnesium, iron, zinc, copper, manganese, molybdenum, selenium, and cobalt are essential in numerous biological and molecular processes regulating cellular homeostasis, humoral, and cellular immune responses, and they also act as cofactors of several enzymes and antioxidant molecules. Vitamin D is a lipid-soluble pre-hormone integral to maintaining skeletal and bone health.  In addition, vitamin D extends to regulating multiple processes in different cell types that express vitamin D receptors. These cells, once activated, participate in metabolic processes such as DNA repair, antioxidant activity, regulation, proliferation, and cell differentiation. As a result, vitamin D deficiency has been extensively investigated concerning cardiovascular diseases, insulin resistance, respiratory diseases, cancer, viral infections, and depression, among others. Hence, this Special Issue aims to disseminate innovative studies that discuss the metabolic and functional disorders related to the deficiency and toxicity of these micronutrients, even as the interactions between them, elucidating mechanisms and functional specificities as approaches used to prevent and attenuate metabolic disturbances and disease progression. Original articles, systematic reviews and meta-analyses, short communications, and narrative reviews that cover these themes will be welcome.

Prof. Dr. Lucia Fatima Campos Pedrosa
Prof. Dr. Karine Cavalcanti Maurício De Sena-Evangelista
Dr. Flávia Fioruci Bezerra
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • essential metals
  • minerals
  • trace elements
  • vitamin D
  • zinc
  • selenium
  • calcium
  • iron
  • copper
  • manganese

Published Papers (5 papers)

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Research

11 pages, 946 KiB  
Article
Vitamin D Deficiency in Obese Children Is Associated with Some Metabolic Syndrome Components, but Not with Metabolic Syndrome Itself
by Jagoda Hofman-Hutna, Michał Hutny, Edyta Matusik, Magdalena Olszanecka-Glinianowicz and Pawel Matusik
Metabolites 2023, 13(8), 914; https://doi.org/10.3390/metabo13080914 - 4 Aug 2023
Viewed by 1216
Abstract
Vitamin D deficiency in children is a common nutritional issue in many populations worldwide, associated not only with skeletal malformations but, as recent studies suggest, also with the development of obesity and metabolic syndrome. The aim of this observational study was to assess [...] Read more.
Vitamin D deficiency in children is a common nutritional issue in many populations worldwide, associated not only with skeletal malformations but, as recent studies suggest, also with the development of obesity and metabolic syndrome. The aim of this observational study was to assess the nutritional status of vitamin D in a group of Polish children with obesity and different grades of metabolic syndrome, with a consequent analysis of the correlation between vitamin D levels and the components of metabolic syndrome. For that purpose, the group of 78 participants (mean age: 14.18 ± 2.67 years) was recruited and further grouped in relation to vitamin D status into two groups of children with and without vitamin D deficiency. The biochemical parameters associated with obesity as well as anthropometric measures were assessed and analysed in search of significant differences between the groups. In the current group of children with obesity and vitamin D deficiency, HDL (45.00 ± 9.29) and adiponectin (7.21 ± 1.64) were found to be significantly lower than in their peers without vitamin D deficiency, whereas W/HtR (0.60 ± 0.04) and TG (171.31 ± 80.75) levels proved to be significantly higher. Body composition analysis using bioelectrical impedance returned no significant findings. The above findings suggest that vitamin D deficiency may influence lipid and glucose metabolism in children, leading to the development of abnormalities characteristic of the metabolic syndrome. A W/HtR parameter was shown to be a sensitive marker of abdominal obesity, which might provide an important means of assessing the correlation between vitamin D and this type of obesity. Independently, vitamin D deficiency may also influence the endocrinological function of adipose tissue, leading to lower concentrations of adiponectin. These in turn presented a linear correlation with the high results of the OGTT in the second hour of the test, hinting at its potential role in the pathophysiology of insulin resistance. Full article
(This article belongs to the Special Issue Metabolic and Functional Disorders of Essential Metals and Vitamin D)
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12 pages, 627 KiB  
Article
Dietary Intake of Micronutrients and Disease Severity in Patients with Amyotrophic Lateral Sclerosis
by Acsa Nara de Araújo Brito Barros, Maria Luisa do Nascimento Felipe, Isabelle Ribeiro Barbosa, Lucia Leite-Lais and Lucia Fátima Campos Pedrosa
Metabolites 2023, 13(6), 696; https://doi.org/10.3390/metabo13060696 - 27 May 2023
Cited by 3 | Viewed by 1387
Abstract
Vitamins and essential metals have been studied as potential risk and prognostic factors in amyotrophic lateral sclerosis (ALS). This study aimed to evaluate the prevalence of inadequate micronutrient intake in ALS patients, comparing subgroups according to the disease severity. Data were obtained from [...] Read more.
Vitamins and essential metals have been studied as potential risk and prognostic factors in amyotrophic lateral sclerosis (ALS). This study aimed to evaluate the prevalence of inadequate micronutrient intake in ALS patients, comparing subgroups according to the disease severity. Data were obtained from the medical records of 69 individuals. Assessment of disease severity was determined by the revised ALS Functional Scale (ALSFRS-R), using the median as the cutoff. The prevalence of inadequate micronutrient intake was estimated using the Estimated Average Requirements (EAR) cut-point method. The prevalence of inadequate vitamin D, E, riboflavin, pyridoxine, folate, cobalamin, calcium, zinc, and magnesium intake was considered severe. Patients with lower ALSFRS-R scores had lower intakes of vitamin E (p < 0.001), niacin (p = 0.033), pantothenic acid (p = 0.037), pyridoxin (p = 0.008), folate (p = 0.009) and selenium (p = 0.001). Therefore, ALS patients should be monitored regarding dietary intake of micronutrients essential in neurological processes. Full article
(This article belongs to the Special Issue Metabolic and Functional Disorders of Essential Metals and Vitamin D)
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11 pages, 1016 KiB  
Article
The Effect of Vitamin D Adequacy on Thyroid Hormones and Inflammatory Markers after Bariatric Surgery
by Roberta França, Adryana Cordeiro, Silvia Elaine Pereira, Carlos José Saboya and Andrea Ramalho
Metabolites 2023, 13(5), 603; https://doi.org/10.3390/metabo13050603 - 27 Apr 2023
Viewed by 1121
Abstract
Vitamin D status affects the clinical and corporal outcomes of postoperative patients who undergo a Roux-en-Y gastric bypass (RYGB). The aim of this study was to evaluate the effect of adequate vitamin D serum concentrations on thyroid hormones, body weight, blood cell count, [...] Read more.
Vitamin D status affects the clinical and corporal outcomes of postoperative patients who undergo a Roux-en-Y gastric bypass (RYGB). The aim of this study was to evaluate the effect of adequate vitamin D serum concentrations on thyroid hormones, body weight, blood cell count, and inflammation after an RYGB. A prospective observational study was conducted with eighty-eight patients from whom we collected blood samples before and 6 months after surgery to evaluate their levels of 25-hydroxyvitamin D 25(OH)D, thyroid hormones, and their blood cell count. Their body weight, body mass index (BMI), total weight loss, and excess weight loss were also evaluated 6 and 12 months after surgery. After 6 months, 58% of the patients achieved an adequate vitamin D nutritional status. Patients in the adequate group showed a decrease in the concentration of thyroid-stimulating hormone (TSH) (3.01 vs. 2.22 µUI/mL, p = 0.017) with lower concentrations than the inadequate group at 6 months (2.22 vs. 2.84 µUI/mL, p = 0.020). Six months after surgery, the group with vitamin D adequacy showed a significantly lower BMI compared with the inadequate group at 12 months (31.51 vs. 35.04 kg/m2, p = 0.018). An adequate vitamin D nutritional status seems to favor a significant improvement in one’s thyroid hormone levels, immune inflammatory profile, and weight loss performance after an RYGB. Full article
(This article belongs to the Special Issue Metabolic and Functional Disorders of Essential Metals and Vitamin D)
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9 pages, 260 KiB  
Article
Parameters of Vitamin D Metabolism in Patients with Hypoparathyroidism
by Artem Zhukov, Alexandra Povaliaeva, Zaur Abilov, Elena Kovaleva, Liliya Usoltseva, Anna Eremkina, Vitaliy Ioutsi, Larisa Dzeranova, Ekaterina Pigarova, Liudmila Rozhinskaya and Natalia Mokrysheva
Metabolites 2022, 12(12), 1279; https://doi.org/10.3390/metabo12121279 - 16 Dec 2022
Cited by 3 | Viewed by 1520
Abstract
Only a few studies evaluating the metabolism of vitamin D in patients with hypoparathyroidism (HypoPT) have been performed thus far, and, in particular, they mainly investigated the process of vitamin D activation (specifically, 1α-hydroxylation). This study, therefore, aimed to evaluate the extended spectrum [...] Read more.
Only a few studies evaluating the metabolism of vitamin D in patients with hypoparathyroidism (HypoPT) have been performed thus far, and, in particular, they mainly investigated the process of vitamin D activation (specifically, 1α-hydroxylation). This study, therefore, aimed to evaluate the extended spectrum of vitamin D metabolites in patients with HypoPT compared to healthy individuals. We examined 38 adult patients with chronic HypoPT in comparison to 38 healthy adults. The assessment included biochemical parameters (total calcium, albumin, phosphorus, creatinine, and magnesium), parathyroid hormone (PTH), and vitamin D metabolites (25(OH)D3, 25(OH)D2, 1,25(OH)2D3, 3-epi-25(OH)D3, and 24,25(OH)2D3) in serum. Our data show that an adequate level of 25(OH)D3 (median 35.3 (29.6; 42.0) ng/mL) is achieved with standard doses of cholecalciferol (median 2000 (2000; 2500) IU per day) in HypoPT patients. They also presented with supraphysiological levels of 1,25(OH)2D3 (median 71 (47; 96) vs. 40 (34; 59) pg/mL, p < 0.001) and the increased production of inactive metabolite (median 24,25(OH)2D3 3.8 (3.0; 5.1) vs. 1.9 (1.3; 2.7) ng/mL, p < 0.001; median 25(OH)D3/24,25(OH)2D3 ratio 8.9 (7.6; 11.1) vs. 13.5 (11.1; 17.0), p < 0.001) as compared to the control group. This might be a consequence of the therapy received (treatment with activated vitamin D) and the pathophysiology of the disease (lack of PTH). The abnormality of vitamin D metabolism does not seem to interfere with the achievement of hypoparathyroidism compensation. Full article
(This article belongs to the Special Issue Metabolic and Functional Disorders of Essential Metals and Vitamin D)
18 pages, 4878 KiB  
Article
Highly Efficient Biotransformation and Production of Selenium Nanoparticles and Polysaccharides Using Potential Probiotic Bacillus subtilis T5
by Yuhua Duan, Mengjun Li, Sishang Zhang, Yidan Wang, Jieya Deng, Qin Wang, Tian Yi, Xingxing Dong, Shuiyuan Cheng, Yi He, Chao Gao and Zhangqian Wang
Metabolites 2022, 12(12), 1204; https://doi.org/10.3390/metabo12121204 - 1 Dec 2022
Cited by 2 | Viewed by 1656
Abstract
Selenium is an essential microelement required for human health. The biotransformation of selenium nanoparticles has attracted increasing attention in recent years. However, little of the literature has investigated the comprehensive evaluation of the strains for practical application and the effect on the functional [...] Read more.
Selenium is an essential microelement required for human health. The biotransformation of selenium nanoparticles has attracted increasing attention in recent years. However, little of the literature has investigated the comprehensive evaluation of the strains for practical application and the effect on the functional properties in the existence of Se. The present study showed the selenite reduction strain Bacillus subtilis T5 (up to 200 mM), which could produce high yields of selenium polysaccharides and selenium nanoparticles in an economical and feasible manner. Biosynthesized selenium nanoparticles by B. subtilis T5 were characterized systematically using UV-vis spectroscopy, FTIR, Zeta Potential, DLS, and SEM techniques. The biosynthesized SeNPs exhibited high stability with small particle sizes. B. subtilis T5 also possessed a tolerance to acidic pH and bile salts, high aggregation, negative hemolytic, and superior antioxidant activity, which showed excellent probiotic potential and can be recommended as a potential candidate for the selenium biopharmaceuticals industry. Remarkably, B. subtilis T5 showed that the activity of α-amylase was enhanced with selenite treatment to 8.12 U/mL, 2.72-fold more than the control. The genus Bacillus was first reported to produce both selenium polysaccharides with extremely high Se-content (2.302 g/kg) and significantly enhance the activity to promote α-amylase with selenium treatment. Overall, B. subtilis T5 showed potential as a bio-factory for the biosynthesized SeNPs and organ selenium (selenium polysaccharide), providing an appealing perspective for the biopharmaceutical industry. Full article
(This article belongs to the Special Issue Metabolic and Functional Disorders of Essential Metals and Vitamin D)
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