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Metabolites
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Natural Products Metabolomics
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Natural Products Metabolomics

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: closed (31 January 2019) | Viewed by 14415

Special Issue Editor

Prof. Dr. Gustavo Zuñiga

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Guest Editor
Departamento de Biología, University of Santiago, Santiago, Chile
Interests: antarctica; climate change; metabolomics; plant biotechnology; plant stress

Special Issue Information

Dear Colleagues,

To identify and quantify metabolites in extracts of natural products is a challenging and urgent task. Metabolomics is a high-performance analytical technique globally-used to measure low molecular weight metabolites, allowing the simultaneous metabolic comparison of different biological samples. Although plants are recognized as prolific sources of bioactive substances, the traditional approach to the discovery of new molecules is time consuming and laborious. In this Special Issue of Metabolites, the use of NMR- or MS-based metabolomics is proposed as an efficient approach to find bioactive metabolites in plants and microorganisms. The coverage of this Special Issue includes, but is not limited to, the following topics:

  • Metabolomics analysis of plants under Climate change.
  • Metabolomics characterization of plant extracts.
  • Metabolomics of the interaction plant-endophytic organisms.
  • Metabolomics screening of biological activities. (antioxidant, antibacterial, antidiabetic, bioplaguicides, etc.)
  • Metabolomics of medicinal plants.
Prof. Dr. Gustavo Zuñiga
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • natural products
  • climate change
  • medicinal plants
  • bioactive metabolites

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Published Papers (3 papers)

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Research

14 pages, 18881 KiB  
Article
An Isotopic Ratio Outlier Analysis Approach for Global Metabolomics of Biosynthetically Talented Actinomycetes
by Jordan Carey, Thanh Nguyen, Jennifer Korchak, Christopher Beecher, Felice de Jong and Amy L. Lane
Metabolites 2019, 9(9), 181; https://doi.org/10.3390/metabo9090181 - 10 Sep 2019
Cited by 4 | Viewed by 4437
Abstract
Actinomycetes are powerhouses of natural product biosynthesis. Full realization of this biosynthetic potential requires approaches for recognizing novel metabolites and determining mediators of metabolite production. Herein, we develop an isotopic ratio outlier analysis (IROA) ultra-high performance liquid chromatography-mass spectrometry (UHPLC/MS) global metabolomics strategy [...] Read more.
Actinomycetes are powerhouses of natural product biosynthesis. Full realization of this biosynthetic potential requires approaches for recognizing novel metabolites and determining mediators of metabolite production. Herein, we develop an isotopic ratio outlier analysis (IROA) ultra-high performance liquid chromatography-mass spectrometry (UHPLC/MS) global metabolomics strategy for actinomycetes that facilitates recognition of novel metabolites and evaluation of production mediators. We demonstrate this approach by determining impacts of the iron chelator 2,2′-bipyridyl on the Nocardiopsis dassonvillei metabolome. Experimental and control cultures produced metabolites with isotopic carbon signatures that were distinct from corresponding “standard” culture metabolites, which were used as internal standards for LC/MS. This provided an isotopic MS peak pair for each metabolite, which revealed the number of carbon atoms and relative concentrations of metabolites and distinguished biosynthetic products from artifacts. Principal component analysis (PCA) and random forest (RF) differentiated bipyridyl-treated samples from controls. RF mean decrease accuracy (MDA) values supported perturbation of metabolites from multiple amino acid pathways and novel natural products. Evaluation of bipyridyl impacts on the nocazine/XR334 diketopiperazine (DKP) pathway revealed upregulation of amino acid precursors and downregulation of late stage intermediates and products. These results establish IROA as a tool in the actinomycete natural product chemistry arsenal and support broad metabolic consequences of bipyridyl. Full article
(This article belongs to the Special Issue Natural Products Metabolomics)
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14 pages, 2555 KiB  
Article
Flavan-3-ols Content in Red Raspberry Leaves Increases under Blue Led-Light Irradiation
by Ryo Kobori, Seiya Hashimoto, Hayato Koshimizu, Shuich Yakami, Mizuki Hirai, Kenta Noro, Takashi Kawasaki and Akiko Saito
Metabolites 2019, 9(3), 56; https://doi.org/10.3390/metabo9030056 - 21 Mar 2019
Cited by 13 | Viewed by 3557
Abstract
Berry fruits are well known to contain large amounts of polyphenol compounds. Among them, flavan-3-ol derivatives are a group of secondary metabolism compounds currently attracting a great deal of attention owing to their health benefits. Not only the fruits, but also the leaves [...] Read more.
Berry fruits are well known to contain large amounts of polyphenol compounds. Among them, flavan-3-ol derivatives are a group of secondary metabolism compounds currently attracting a great deal of attention owing to their health benefits. Not only the fruits, but also the leaves of raspberry plants, are highly esteemed for tea making around the world and are largely used for food. In this report, we discuss the results of our study on the effect of light and temperature on polyphenol accumulation in raspberry leaves. When raspberry was cultivated in a plant factory unit and light intensity, wavelength, and temperature were varied, the amount of total polyphenol increased under blue light. Quantitative determination of (+)-catechin, (–)-epicatechin, procyanidin B4, flavan-3-ol trimer, which are flavan-3-ol derivatives, was carried out using HPLC, whereby we confirmed their increase under blue light. Semi-quantitative RT-PCR showed correlation between chalcone synthase (CHS) gene expression and the amounts of the compounds measured in the leaves. Full article
(This article belongs to the Special Issue Natural Products Metabolomics)
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24 pages, 6621 KiB  
Article
HPLC-qTOF-MS/MS-Based Profiling of Flavan-3-ols and Dimeric Proanthocyanidins in Berries of Two Muscadine Grape Hybrids FLH 13-11 and FLH 17-66
by Seyit Yuzuak, James Ballington and De-Yu Xie
Metabolites 2018, 8(4), 57; https://doi.org/10.3390/metabo8040057 - 26 Sep 2018
Cited by 60 | Viewed by 5666
Abstract
FLH 13-11 FL and FLH 17-66 FL are two interspecific hybrid varieties of muscadine grape resulting from the cross of Vitis munsoniana (Simpson) ex Munson and V. rotundifolia. However, profiles of flavan-3-ols and proanthocyanidins in these two hybrids have not been characterized. [...] Read more.
FLH 13-11 FL and FLH 17-66 FL are two interspecific hybrid varieties of muscadine grape resulting from the cross of Vitis munsoniana (Simpson) ex Munson and V. rotundifolia. However, profiles of flavan-3-ols and proanthocyanidins in these two hybrids have not been characterized. Herein, we report the use of high-performance liquid chromatography-quadrupole, time-of-flight, tandem mass spectrometry (HPLC-qTOF-MS/MS) to characterize these two groups of metabolites in berries. Ripe berries collected from two consecutive cropping years were used to extract metabolites. Metabolites were ionized using the negative mode. Collision-induced dissociation was performed to fragmentize ions to obtain feature fragment profiles. Based on standards, MS features, and fragments resulted from MS/MS, four flavan-3-ol aglycones, 18 gallated or glycosylated conjugates, and eight dimeric procyanidins, were annotated from berry extracts. Of these 30 metabolites, six are new methylated flavan-3-ol gallates. Furthermore, comparative profiling analysis showed obvious effects of each cultivar on the composition these 30 metabolites, indicating that genotypes control biosynthesis. In addition, cropping seasons altered profiles of these metabolites, showing effects of growing years on metabolic composition. These data are informative to enhance the application of the two cultivars in grape and wine industries in the future. Full article
(This article belongs to the Special Issue Natural Products Metabolomics)
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