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Metabolites
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Metabolomics and Its Application in Neurological Diseases and Disease Models
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Metabolomics and Its Application in Neurological Diseases and Disease Models

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (15 November 2021) | Viewed by 6480

Special Issue Editor

Prof. Dr. Paul Wood

E-Mail Website
Guest Editor
Metabolomics Unit, Lincoln Memorial University, Harrogate, TN, USA
Interests: metabolomics; lipidomics of diseases; disease models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolomics and lipidomics evaluations provide in-depth descriptions of the active phenotype in diseases and disease models. These “omics” technologies can generate extensive volumes of biochemical data from which aberrations can be detected. Ultimately, these data can provide new assays for early disease detection, disease progression, and disease response to experimental therapies. Of even greater impact is the potential to define new points of therapeutic intervention in neurological diseases with multi-factorial originations.

We invite researchers to submit original research or reviews of “omics” progress in the study of amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Lewy body disease (LBD), lysosomal storage disease, mild cognitive impairment (MCI), multiple sclerosis (MS), Parkinson’s disease (PD), traumatic brain injury (TBI), and traumatic spinal cord injury (TSCI).

Our issue invites investigators to present relevant data to these areas of research. This resulting compendium should significantly contribute to establishing areas of focus for future research studies of multi-factorial human neurological diseases.

Prof. Dr. Paul Wood
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • lipidomics
  • disease mechanisms
  • disease models

Published Papers (2 papers)

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Research

13 pages, 2343 KiB  
Article
Human Brain Lipidomics: Pilot Analysis of the Basal Ganglia Sphingolipidome in Parkinson’s Disease and Lewy Body Disease
by Aaron W. Beger, Beatrix Dudzik, Randall L. Woltjer and Paul L. Wood
Metabolites 2022, 12(2), 187; https://doi.org/10.3390/metabo12020187 - 18 Feb 2022
Cited by 9 | Viewed by 2660
Abstract
Sphingolipids constitute a complex class of bioactive lipids with diverse structural and functional roles in neural tissue. Lipidomic techniques continue to provide evidence for their association in neurological diseases, including Parkinson’s disease (PD) and Lewy body disease (LBD). However, prior studies have primarily [...] Read more.
Sphingolipids constitute a complex class of bioactive lipids with diverse structural and functional roles in neural tissue. Lipidomic techniques continue to provide evidence for their association in neurological diseases, including Parkinson’s disease (PD) and Lewy body disease (LBD). However, prior studies have primarily focused on biological tissues outside of the basal ganglia, despite the known relevancy of this brain region in motor and cognitive dysfunction associated with PD and LBD. Therefore electrospray ionization high resolution mass spectrometry was used to analyze levels of sphingolipid species, including ceramides (Cer), dihydroceramides (DHC), hydoxyceramides (OH-Cer), phytoceramides (Phyto-Cer), phosphoethanolamine ceramides (PE-Cer), sphingomyelins (SM), and sulfatides (Sulf) in the caudate, putamen and globus pallidus of PD (n = 7) and LBD (n = 14) human subjects and were compared to healthy controls (n = 9). The most dramatic alterations were seen in the putamen, with depletion of Cer and elevation of Sulf observed in both groups, with additional depletion of OH-Cer and elevation of DHC identified in LBD subjects. Diverging levels of DHC in the caudate suggest differing roles of this lipid in PD and LBD pathogenesis. These sphingolipid alterations in PD and LBD provide evidence for biochemical involvement of the neuronal cell death that characterize these conditions. Full article
(This article belongs to the Special Issue Metabolomics and Its Application in Neurological Diseases and Disease Models)
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15 pages, 1784 KiB  
Article
Plasma Metabolite Markers of Parkinson’s Disease and Atypical Parkinsonism
by Meerakhan Pathan, Junfang Wu, Hans-Åke Lakso, Lars Forsgren and Anders Öhman
Metabolites 2021, 11(12), 860; https://doi.org/10.3390/metabo11120860 - 09 Dec 2021
Cited by 9 | Viewed by 3207
Abstract
Differentiating between Parkinson’s disease (PD) and the atypical Parkinsonian disorders of multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) is difficult clinically due to overlapping symptomatology, especially at early disease stages. Consequently, there is a need to identify metabolic markers for these [...] Read more.
Differentiating between Parkinson’s disease (PD) and the atypical Parkinsonian disorders of multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) is difficult clinically due to overlapping symptomatology, especially at early disease stages. Consequently, there is a need to identify metabolic markers for these diseases and to develop them into viable biomarkers. In the present investigation, solution nuclear magnetic resonance and mass spectrometry metabolomics were used to quantitatively characterize the plasma metabolomes (a total of 167 metabolites) of a cohort of 94 individuals comprising 34 PD, 12 MSA, and 17 PSP patients, as well as 31 control subjects. The distinct and statistically significant differences observed in the metabolite concentrations of the different disease and control groups enabled the identification of potential plasma metabolite markers of each disorder and enabled the differentiation between the disorders. These group-specific differences further implicate disturbances in specific metabolic pathways. The two metabolites, formic acid and succinate, were altered similarly in all three disease groups when compared to the control group, where a reduced level of formic acid suggested an effect on pyruvate metabolism, methane metabolism, and/or the kynurenine pathway, and an increased succinate level suggested an effect on the citric acid cycle and mitochondrial dysfunction. Full article
(This article belongs to the Special Issue Metabolomics and Its Application in Neurological Diseases and Disease Models)
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