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Metabolites
Special Issues
Oxidative Stress and Metabolic Disorders
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Oxidative Stress and Metabolic Disorders

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 3799

Special Issue Editors

Dr. Begoña Cerdá

E-Mail Website
Guest Editor
Department of Pharmacy, Faculty of Pharmacy and Nutrition, Universidad Católica San Antonio de Murcia (UCAM), Campus de los Jerónimos, Guadalupe, 30107 Murcia, Spain
Interests: oxidative stress; bioavailability; ellagitanins; bioactive compounds; microbiota; inflammation
Special Issues, Collections and Topics in MDPI journals
Dr. Javier Marhuenda

E-Mail Website
Guest Editor
Department of Pharmacy, Faculty of Health Sciences, Universidad Católica San Antonio de Murcia (UCAM), Campus de los Jerónimos, 30107 Guadalupe, Murcia, Spain
Interests: oxidative stress; polyphenols; bioactive compounds; bioavailability; metabolomics
Special Issues, Collections and Topics in MDPI journals
Dr. Pilar Zafrilla

E-Mail Website
Guest Editor
Department of Pharmacy, Faculty of Health Sciences, Universidad Católica San Antonio de Murcia (UCAM), Campus de los Jerónimos, Guadalupe, 30107 Murcia, Spain
Interests: clinical trials; oxidative stress; bioavailability; bioactive compounds; inflammation; Endothelial damage markers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress has been proposed as a potential inducer of inflammation, with involvement in the development of chronic pathologies such as metabolic diseases. Oxidative stress is produced due to an imbalance in oxide reduction metabolism generated by the uncontrolled production of reactive oxygen and nitrogen species. It is widely known that the overproduction of reactive oxygen and nitrogen species causes endothelial dysfunction, tissue deterioration, and therefore, an increase in the appearance of different pathologies.

This Special Issue aims to highlight the connection between oxidative stress and metabolic diseases. Authors are invited to submit original articles and well documented reviews related, but not limited to, the identification of metabolites/bioactive compounds with biological and/or clinical relevance (possibly in relation to oxidative stress or metabolic pathologies) and metabolomics and descriptions of new oxidative stress biomarkers.


Dr. Begoña Cerdá
Dr. Javier Marhuenda
Dr. Pilar Zafrilla
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • biomarkers
  • metabolomics
  • bioactive compounds
  • biavailability
  • metabolic disorders
  • antioxidant capacity

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Published Papers (1 paper)

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Research

19 pages, 1948 KiB  
Article
Oxidative Stress Modulation by Cameroonian Spice Extracts in HepG2 Cells: Involvement of Nrf2 and Improvement of Glucose Uptake
by Achille Parfait Atchan Nwakiban, Stefania Cicolari, Stefano Piazza, Fabrizio Gelmini, Enrico Sangiovanni, Giulia Martinelli, Lorenzo Bossi, Eugénie Carpentier-Maguire, Armelle Deutou Tchamgoue, Gabriel A. Agbor, Jules-Roger Kuiaté, Giangiacomo Beretta, Mario Dell’Agli and Paolo Magni
Metabolites 2020, 10(5), 182; https://doi.org/10.3390/metabo10050182 - 1 May 2020
Cited by 15 | Viewed by 3423
Abstract
Oxidative stress plays a relevant role in the progression of chronic conditions, including cardiometabolic diseases. Several Cameroonian plants, including spices, are traditionally used as herbal medicines for the treatment of diseases where oxidative stress contributes to insulin resistance, like type 2 diabetes mellitus. [...] Read more.
Oxidative stress plays a relevant role in the progression of chronic conditions, including cardiometabolic diseases. Several Cameroonian plants, including spices, are traditionally used as herbal medicines for the treatment of diseases where oxidative stress contributes to insulin resistance, like type 2 diabetes mellitus. This study evaluated the antioxidant capacity and the effects on oxidative-stress-induced impairment of glucose uptake of 11 Cameroonian spice extracts. H2O2-induced reactive oxygen species (ROS) production by human HepG2 cells was significantly reduced by 8/11 extracts. The most effective extracts, Xylopia parviflora, Echinops giganteus, and Dichrostachys glomerata, showed a concentration-dependent ROS-scavenging activity, which involved Nrf2 translocation into the nucleus. Xylopia parviflora, Tetrapleura tetraptera, Dichrostachys glomerata, Aframomum melegueta, and Aframomum citratum extracts showed the highest antioxidant capacity, according to oxygen radical absorbance capacity (ORAC) (2.52–88 μM Trolox Eq/g of extract), ferric-reducing antioxidant power (FRAP) (40.23–233.84 mg gallic acid Eq/g of extract), and total phenol (8.96–32.96% mg gallic acid Eq/g of extract) assays. In HepG2 cells, glucose uptake was stimulated by 4/11 extracts, similarly to insulin and metformin. H2O2-induced oxidative stress reduced glucose uptake, which was rescued by pretreatment with Xylopia aethiopica, Xylopia parviflora, Scorodophloeus zenkeri, Monodora myristica, and Dichrostachys glomerata extracts. The ROS-scavenging ability of the spice extracts may reside in some secondary metabolites observed by phytochemical profiling (reverse-phase high-performance liquid chromatography coupled to a diode array detector (HPLC-UV-DAD)). Further studies are needed to better clarify their biological activities and potential use to control oxidative stress and promote insulin sensitivity. Full article
(This article belongs to the Special Issue Oxidative Stress and Metabolic Disorders)
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