Nutrition and Metabolism in Human Diseases 2nd Edition

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 15 August 2024 | Viewed by 1118

Special Issue Editor


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Guest Editor
School of Medicine, Zhejiang University, Hangzhou 310058, China
Interests: nutrition; metabolism; trace elements; diabetes; aging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nutrition and metabolism are critical life-sustaining parts of human health. The nutritional and metabolic status profoundly affects the function and activity of the endocrine and immune systems. Malnutrition and the disruption of metabolic processes widely affect and exacerbate various health problems, including chronic diseases, infectious diseases, and death. On the contrary, interventions with specific nutrients or metabolites are effective in disease prevention and management. Many basic metabolic pathways are evolutionarily conserved due to their fundamental roles in vastly different species, which make it possible to use model organisms to study the interaction among nutrition, metabolism, and the pathological processes of diseases. Recent advances in nutritional evaluation, metabolic profiling, the establishment of animal models, and the development of novel analytical methods have provided insights into the basis of nutrition- and metabolism-related diseases. However, many theoretical and clinical issues remain to be explored. Therefore, for this Special Issue, we welcome high-quality original research papers and reviews in the fields of nutrition and metabolism.

We welcome submissions on research across various diseases, including obesity, diabetes, cardiovascular diseases, fatty liver disease, cancer, neurodegenerative diseases, autoimmune diseases, infectious diseases, and any other diseases related to nutrition and metabolism. The topics that will be covered include but are not limited to studies on the nutritional intervention for disease prevention and management, mechanisms of nutrient- and metabolite-regulated pathological processes, animal models for nutrition and disease, methodologies for the characterization of the metabolic status in disease, and causality between nutritional or metabolic factors and diseases.

Dr. Xinhui Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • metabolism
  • nutrient
  • metabolite
  • disease

Published Papers (1 paper)

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Research

12 pages, 1181 KiB  
Article
Genetic Evidence for Causal Relationships between Plasma Eicosanoid Levels and Cardiovascular Disease
by Xukun Bi, Yiran Wang, Yangjun Lin, Meihui Wang and Xiaoting Li
Metabolites 2024, 14(6), 294; https://doi.org/10.3390/metabo14060294 - 23 May 2024
Viewed by 581
Abstract
Cardiovascular diseases are the most common causes of mortality and disability worldwide. Eicosanoids are a group of bioactive metabolites that are mainly oxidized by arachidonic acid. Eicosanoids play a diverse role in cardiovascular diseases, with some exerting beneficial effects while others have detrimental [...] Read more.
Cardiovascular diseases are the most common causes of mortality and disability worldwide. Eicosanoids are a group of bioactive metabolites that are mainly oxidized by arachidonic acid. Eicosanoids play a diverse role in cardiovascular diseases, with some exerting beneficial effects while others have detrimental consequences. However, a causal relationship between eicosanoid levels and cardiovascular disease remains unclear. Six single nucleotide polymorphisms (SNPs) with strong associations with plasma eicosanoid levels were selected. Summary-level data for cardiovascular disease were obtained from publicly available genome-wide association studies. A two-sample MR analysis identified that plasma eicosanoid levels were inversely correlated with unstable angina pectoris (OR 1.06; 95% CI 1–1.12; p = 0.04), myocardial infarction (OR 1.05; 95% CI 1.02–1.09; p = 0.005), ischemia stroke (OR 1.05; 95% CI 1–1.11; p = 0.047), transient ischemic attack (OR 1.03; 95% CI 1–1.07; p = 0.042), heart failure (OR 1.03; 95% CI 1.01–1.05; p = 0.011), and pulmonary embolism (OR 1.08; 95% CI 1.02–1.14; p = 1.69 × 10−6). In conclusion, our data strongly suggest a genetic causal link between high plasma eicosanoid levels and an increased cardiovascular disease risk. This study provides genetic evidence for treating cardiovascular diseases. Full article
(This article belongs to the Special Issue Nutrition and Metabolism in Human Diseases 2nd Edition)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Tentative Title: Multi-Omics Unravels Metabolic Alterations in a murine model of Infantile hemangioma receiving Oxymatrine therapy
Author: Junkai Yan

Tentative Title: Metabolic markers predicts diabetic nephropathy development through multiple omics
Author: Jianbo Wu

Tentative Title: Research Progress of SLC7A11-Mediated Ferroptosis in Different Diseases
Author: Hongbin Luo

 

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