Sex Differences in Behavioral and Metabolic Effects of Gene Manipulation and Mutation
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 3317
Special Issue Editors
Interests: neuropeptides; anxiety; sex-related differences; emotional and metabolic disorders; maternal care; perineuronal nets
Interests: sex differences in brain and behavior; developmental origin of health and disease; endocrine disruptors; emotional and metabolic disorders; gene–environment interaction
Special Issues, Collections and Topics in MDPI journals
Interests: metabolic inflammation; NLRP3 inflammasome; diet-induced metabolic diseases; advanced glycation and products
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gender and biological sex impact the pathogenesis and vulnerability to numerous diseases, including metabolic, neuroendocrine, and neuropsychiatric disorders.
Experimental and clinical evidence has demonstrated that the sex-linked hormonal and environmental background strongly affects functional consequences of gene manipulation and mutation, an aspect that is not often carefully evaluated.
Genetically modified animal models are essential tools to identify the central and peripheral circuits underlying sex differences in metabolism, feeding, and emotional behavior and vulnerability to metabolic disorders and their comorbidities. The phenotype induced in one sex by a genetic manipulation or mutation may be absent, or even be reversed, in the other sex.
This special issue will focus on the new advances in our knowledge on how genetic manipulation in animals as well as human gene mutations can unravel several aspects of metabolic and behavioral functions which are regulated differently in males and females.
The topics that will be covered by this Special Issue comprise but are not limited to sex-related differences of gene alteration (manipulation or mutation) on different metabolic and behavioral functions, including:
- tissue metabolism
- peripheral metabolic signals
- energy balance
- hormone environment
- steroid-mediated functions
- feeding behavior
- emotional behavior
- developmental factors
- gene environment interaction
- eating disorders
- metabolic disorders
- obesity
Prof. Dr. Paola Palanza
Prof. Dr. Massimo Collino
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- gene-by-sex interactions
- gene manipulation
- gene mutation
- sex steroid hormones
- metabolic functions
- behavioral function
