Skeletal Muscle Thermogenesis and Energy Metabolism
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (15 January 2022) | Viewed by 11705
Special Issue Editors
Interests: ageing; sarcopenia; diabetes; metabolism
Special Issue Information
Dear Colleagues,
Temperature homeostasis (37 ºC) is essential for optimal physiological activity and the survival of endotherms (birds and mammals). Both shivering and nonshivering thermogenic mechanisms (NST) contribute to temperature homeostasis. In mammals, skeletal muscle and brown adipose tissue (BAT) are major sites of thermogenesis and play key roles in temperature homeostasis. Lately, there has been considerable interest in activating BAT-mediated NST in adult humans to increase energy metabolism. However, the relative paucity of BAT in adult humans and its absence in obese individuals makes it relatively inefficient in increasing metabolism and regulating obesity. On the other hand, skeletal muscle-based shivering and NST mechanisms remain active throughout adult life and are the primary means for heat production in most mammals, including humans. Another advantage is that skeletal muscle represents ~40–45% of body mass and recruitment of skeletal muscle activity through shivering, and NST mechanisms (especially activation of futile SERCA activity) can be effective to increase energy expenditure and whole-body metabolism. In addition, a combination of cold and exercise could be more effective in enhancing muscle energy expenditure and whole-body metabolism in humans. The aim and scope of this Special Issue is to identify the different mechanisms of muscle thermogenesis and discuss their relevance to whole-body metabolism in mammals.
Dr. Muthu Periasamy
Dr. Naresh Chandra Bal
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
