Progress in Metabolomic Analysis in Medicinal Plants
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Plant Metabolism".
Deadline for manuscript submissions: closed (16 February 2024) | Viewed by 8777
Special Issue Editors
Interests: medicinal plants; metabolomics; phenolics; chemosystematics
Interests: phytochemistry; molecular networking
Interests: phytochemistry; metabolomics; tissue cultures
Special Issue Information
Dear Colleagues,
Medicinal plants have been discovered and used in traditional medical procedures. Plants produce hundreds of phytochemicals, plant-derived natural products, for use in various environmental and biological purposes. They also comprise more than a third of the approved drugs in the market. Eventually, the origination of drugs from phytochemicals declined to owe the redundancy of the identified compounds, together with the high cost of isolation, purification, and structure elucidation. To overcome these limitations, metabolomics was introduced as a modern technique for the holistic analysis of these phytochemicals.
Progress in mass-spectrometry-based platforms such as GC-MS and HRLC-MS helped in the rapid separation and identification of several major and minor metabolites. Such analysis can be a valuable tool for recognizing prospective bioactive molecules from medicinal plants and the speedy determination of their abundance in different plant parts.
Since many wild medicinal plants face a high risk of extinction due to climate change, more efforts are required to investigate metabolites of other related species that are available from the same genus or family to search for alternative sources of the same active compounds found in these rare and endangered medicinal species.
Molecular networking, also known as spectral similarity networks, is a computational tool for the organization of tandem mass spectrometry data that unveil the hidden connections of the chemical space within. Recently, it has benefited chemists in many research disciplines, especially natural product drug discoveries and metabolomics studies.
In the current Special Issue, entitled “Progress in Metabolomic Analysis in Medicinal Plants”, we welcome authors to submit original manuscripts that use metabolomics approaches, either alone or in conjunction with other bioinformatic strategies, to answer one or more of the following study objectives, related to the metabolomics of medicinal plants:
- Dereplication of metabolites via GC-MS and LC-MS analysis
- Metabolic investigation of available botanical taxa related to the known medicinal species that could be contained within the same bioactive constituents
- Metabolomic comparison of different plant organs and/or the whole plant from different locali-ties
- Molecular network-guided cataloging of the plant metabolome
- Metabolites’ computational in silico studies
Prof. Dr. Mona Mohamed Marzouk
Dr. Nesrine Mahmoud Hegazi
Dr. Mai Mohamed Farid Kotob
Guest Editors
Manuscript Submission Information
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Keywords
- natural products
- secondary metabolites
- metabolomic pathway
- GC/MS, LC-MS/MS
- drug discovery
- molecular networking
- forthcoming medicinal plant
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