Lichen Secondary Metabolites in Cancer Research
A special issue of Metabolites (ISSN 2218-1989).
Deadline for manuscript submissions: 31 March 2025 | Viewed by 86
Special Issue Editors
Interests: antioxidant activity; HPLC; extraction; bioactivity; phytochemical analysis; compound isolation; chromatography; think layer
Special Issues, Collections and Topics in MDPI journals
Interests: cancer cells; secondary metabolites; apoptosis; cell culture; cell signaling; cancer cell biology; cell proliferation; cell migration; flow cytometry; Western blot analysis; cell cycle analysis; cytotoxicity; molecular oncology; anti-cancer screening; cancer cell metabolism; cell imaging; resistance
Special Issue Information
Dear Colleagues,
We would like to introduce the Special Issue titled “Lichen Secondary Metabolites in Cancer Research” published by the Metabolites journal.
Lichens represent a symbiotic association between at least two partners, known as mycobiont (fungi) and photobiont (green algae, cyanobacteria). This small ecosystem produces a great source of bioactive compounds, which are natural in origin. Their biological and ecological potential was overlooked for several years even though the compounds were continuously identified. Lichens are interesting because of secondary compounds yielded, as we can extract from 5-10% of the dry weight of the thallus in some lichens to up to 30% in others. Secondary compounds are suitable candidates for study of their physical and chemical properties, which are important in applicative research. The extraction of secondary compounds is also key to identify pure metabolites that can be studied for biological application.
Despite advances in diagnostic and therapeutic approaches, statistical data indicate a global increase in newly diagnosed cancer cases. The development of new anticancer drugs is a constant challenge in oncology research. The cytotoxic and antiproliferative activities of various lichens and their secondary metabolites have been demonstrated in a broad spectrum of in vitro cancer models.
The great challenge in this field concerns the application of secondary metabolites in cancer research. Papers discussing the pro-apoptotic, antiproliferative, anti-cancer, and TME-modulating effects of secondary metabolites would be greatly appreciated.
Dr. Michal Goga
Dr. Martin Kello
Guest Editors
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Keywords
- identification of lichen substances
- extraction
- purification
- methodology
- anti-cancer effects
- epigenetics
- apoptosis pathways modulation
- resistance mechanisms
- tumor microenvironment modulation
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