Metabolites, Volume 15, Issue 8
August 2025 - 70 articles
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Cover Story: Urinary small extracellular vesicles provide a new source of biomarkers for chronic kidney disease of unknown etiology (CKDu), a disease that is prevalent among young male agricultural workers who toil in hot, humid areas around the world. A limited set of workers provided two urine samples on the same day, at the beginning and end of the workday. Isolated small extracellular vesicles from workers who had early symptoms of kidney disease, as determined by KODIGO standards, contained altered expression of two inflammation-associated surface proteins, CD25 and CD45. In addition, 21 lipids, including several bioactive lipids, e.g., DAG, LPC, LPE, PI, and PE(O), distinguished these workers from those without kidney impairment. The approach used by this pilot study should be further evaluated with a larger population. View this paper