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Metabolites, Volume 15, Issue 8

August 2025 - 70 articles

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Cover Story: Urinary small extracellular vesicles provide a new source of biomarkers for chronic kidney disease of unknown etiology (CKDu), a disease that is prevalent among young male agricultural workers who toil in hot, humid areas around the world. A limited set of workers provided two urine samples on the same day, at the beginning and end of the workday. Isolated small extracellular vesicles from workers who had early symptoms of kidney disease, as determined by KODIGO standards, contained altered expression of two inflammation-associated surface proteins, CD25 and CD45. In addition, 21 lipids, including several bioactive lipids, e.g., DAG, LPC, LPE, PI, and PE(O), distinguished these workers from those without kidney impairment. The approach used by this pilot study should be further evaluated with a larger population. View this paper

Articles (70)

  • Article
  • Open Access
1 Citations
1,045 Views
15 Pages

21 August 2025

Background: Liuwei Dihuang Pills, a classic traditional Chinese medicine formula, has been widely used in clinical practice for its multiple pharmacological effects. However, the systematic characterization and identification of its chemical constitu...

  • Article
  • Open Access
725 Views
12 Pages

Antiparasitic Effect of Polyphenols and Terpenes from Natural Products Against Trypanosoma cruzi and Leishmania mexicana

  • Diana V. Navarrete-Carriola,
  • Gildardo Rivera,
  • Eyra Ortiz-Pérez,
  • Alma D. Paz-González,
  • Ana Verónica Martínez-Vázquez,
  • Laura Victoria Aquino-González,
  • Liliana Argueta-Figueroa,
  • Michael P. Doyle and
  • Adriana Moreno-Rodríguez

21 August 2025

Background: Worldwide, the number of cases of parasitic diseases has been increasing; however, available treatments have variable adverse effects and low efficacy, mainly in Neglected Tropical Diseases such as Chagas disease and Leishmaniasis. Theref...

  • Article
  • Open Access
801 Views
18 Pages

Modeling the Sensory Characteristics of Japanese Sake Using the Sake Metabolome Analysis Method

  • Takuji Kobayashi,
  • Yuko Komatsu-Hata,
  • Ryota Saito,
  • Hisashi Yazawa,
  • Masayuki Takahashi,
  • Ken Oda and
  • Kazuhiro Iwashita

20 August 2025

Background/Objectives: The components of food and beverages are important elements that determine their palatability. Although the components of sake, a traditional Japanese alcoholic beverage, have been studied for many years, their correlation with...

  • Article
  • Open Access
661 Views
13 Pages

20 August 2025

Background: Metabolomics is a powerful tool used for the evaluation of sugarcane components which are key factors influencing its response to biotic and abiotic stresses. However, little is known about the compositional variability and diversity of t...

  • Article
  • Open Access
895 Views
16 Pages

Differential Impacts of Environmentally Relevant Microplastics on Gut Barrier Integrity in Mice Fed High-Fat Diet Versus Normal Chow Diet

  • Huixia Niu,
  • Ying Yang,
  • Yuting Zhou,
  • Xue Ma,
  • Zhehao Ding,
  • Manjin Xu,
  • Lizhi Wu,
  • Xueqing Li,
  • Mingluan Xing and
  • Qin Zhang
  • + 6 authors

20 August 2025

Background: Despite escalating global pollution from microplastics (MPs) and the concurrent surge in high-fat food consumption, the health impacts of MP exposure on individuals under different dietary patterns remain poorly understood. Methods: This...

  • Article
  • Open Access
2,511 Views
12 Pages

Effects of IGF1 rs6214 Polymorphism and Milk Consumption on Serum Levels of IGF-1 and GH and Body Composition

  • Julio Cesar Grijalva-Avila,
  • Ignacio Villanueva-Fierro,
  • Sandra Consuelo Martínez-Estrada,
  • Gerardo Grijalva-Avila,
  • Alonso Gándara-Mireles,
  • Gildardo Rivera,
  • Antonio Loera-Castañeda,
  • Horacio Almanza-Reyes,
  • Leslie Patrón-Romero and
  • Verónica Loera-Castañeda

20 August 2025

Milk and dairy are rich in insulin-like growth factor 1 (IGF-1), a protein secreted through the action of growth hormone (GH) and implicated in growth and metabolism. Objective: This study aimed to investigate the roles of milk intake and body compos...

  • Article
  • Open Access
581 Views
16 Pages

19 August 2025

Background/Objectives: The aim of this study was to explore the effects of diets with different protein levels on the metabolite composition and metabolic pathways of the longest dorsal muscle of Tibetan pigs, in order to provide a metabolic basis fo...

  • Review
  • Open Access
1,186 Views
26 Pages

Review of Biological Activities of Some Rare Oils from Amazonian Plants

  • Luana Merckling-Almeida da Silva,
  • Nicolas Merckling,
  • Enrico Bigi,
  • Katiane Cunha de Melo and
  • Iuliana Popa

19 August 2025

Background/Objectives: A great biodiversity of compounds from Brazilian medicinal plants are considered to be a promising source for biological activities in the cosmetics and pharmaceuticals sectors. Lipids and mainly fatty acids from Brazilian medi...

  • Review
  • Open Access
1,176 Views
15 Pages

Aldosterone and Cardiovascular Risk Across the Lifespan

  • Roshan A. Ananda,
  • Trevor A. Mori and
  • Jun Yang

17 August 2025

Aldosterone excess, particularly in the context of primary aldosteronism, is associated with adverse cardiovascular outcomes. Historically considered a condition of resistant hypertension with hypokalaemia, patients with primary aldosteronism often e...

  • Article
  • Open Access
1 Citations
835 Views
15 Pages

Choline Metabolism to the Proatherogenic Metabolite Trimethylamine Occurs Primarily in the Distal Colon Microbiome In Vitro

  • Anthony M. Buckley,
  • Sarah Zaidan,
  • Michael G. Sweet,
  • Duncan J. Ewin,
  • Juanita G. Ratliff,
  • Aliyah Alkazemi,
  • William Davis Birch,
  • Ashley M. McAmis and
  • Andrew P. Neilson

16 August 2025

Background/Objectives: Gut microbial metabolism of choline and related quaternary amines to trimethylamine (TMA) is the first step in the production of trimethylamine N-oxide (TMAO), a circulating metabolite that contributes to the development of ath...

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