Gut Microbe-Derived Metabolites in the Onset of Chronic Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Microbiology and Ecological Metabolomics".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1063

Special Issue Editors


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Guest Editor
Department of Medicine, National University of Singapore, Singapore, Singapore
Interests: gut microbiome; chronic gut disease; biologic therapies; diet; non-obese non-alcoholic fatty liver disease

E-Mail Website
Guest Editor
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Interests: gut microbes in diseases

Special Issue Information

Dear Colleagues,

Microbial metabolites are known to modulate host physiology and immunity. Gut microbes live in dense communities along the luminal tract metabolizing host-consumed substrate, host-produced metabolites, and responding to immune cells. These substrates and metabolites are converted to compounds that have a direct effect on the host through absorption across the intestinal mucosa or serve as substrates or anti-microbial effects on other microbes in the gut. Multi-omics studies of the gut microbiome have served to identify microbial metabolites and microbial taxa associated with intestinal chronic diseases.

The aim of this special issue is to identify more novel microbial metabolites that are potential markers for gut chronic diseases. Original research, methods papers and comprehensive reviews on these topics are welcome.

Dr. Jonathan Wei Jie Lee
Dr. Adrian Low
Guest Editors

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Keywords

  • gut microbiome
  • chronic gut disease
  • sulfidogenic bacteria
  • methanogens
  • secondary bile acids
  • short-chain fatty acids
  • tryptophan metabolites

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Published Papers (1 paper)

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Review

14 pages, 974 KiB  
Review
The Influence of Premature Birth on the Development of Pulmonary Diseases: Focus on the Microbiome
by Magdalena Wolska, Tomasz Piotr Wypych and Pilar Rodríguez-Viso
Metabolites 2024, 14(7), 382; https://doi.org/10.3390/metabo14070382 - 11 Jul 2024
Viewed by 824
Abstract
Globally, around 11% of neonates are born prematurely, comprising a highly vulnerable population with a myriad of health problems. Premature births are often accompanied by an underdeveloped immune system biased towards a Th2 phenotype and microbiota dysbiosis. Typically, a healthy gut microbiota interacts [...] Read more.
Globally, around 11% of neonates are born prematurely, comprising a highly vulnerable population with a myriad of health problems. Premature births are often accompanied by an underdeveloped immune system biased towards a Th2 phenotype and microbiota dysbiosis. Typically, a healthy gut microbiota interacts with the host, driving the proper maturation of the host immunity. However, factors like cesarean section, formula milk feeding, hospitalization in neonatal intensive care units (NICU), and routine antibiotic treatments compromise microbial colonization and increase the risk of developing related diseases. This, along with alterations in the innate immune system, could predispose the neonates to the development of respiratory diseases later in life. Currently, therapeutic strategies are mainly focused on restoring gut microbiota composition using probiotics and prebiotics. Understanding the interactions between the gut microbiota and the immature immune system in premature neonates could help to develop novel therapeutic strategies for treating or preventing gut–lung axis disorders. Full article
(This article belongs to the Special Issue Gut Microbe-Derived Metabolites in the Onset of Chronic Diseases)
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