Metabolomic Studies of the Human Gut Microbiome
A special issue of Metabolites (ISSN 2218-1989).
Deadline for manuscript submissions: closed (30 November 2014)
Special Issue Editor
Special Issue Information
Dear Colleagues,
Despite tremendous advances in characterizing the microbial diversity within the gastrointestinal tract, very little is known about the function and role of even the most dominant bacterial species within the human host. It is becoming widely accepted that the metabolic products formed by gut bacteria directly impact on human health and disease, particularly regarding immune response and inflammation. Emerging evidence suggests that these metabolites play an important role in the development of many diseases including diabetes, cardiovascular disease and cancer. In most cases, the products of metabolism are uncharacterized and their mechanism of action unknown. This Special Issue of Metabolites “Metabolomic Studies of the Human Gut Microbiome” will be dedicated to areas of research, which use metabolomic methodologies to establish the link between microbial diversity and metabolic functionality. The topics that will be covered by this Special Issue will be those that address identifying microbial metabolites, particularly at their in vivo concentrations, establishing their mechanism of formation and the bacterial species responsible. Metabolites produced by both commensal and pathogenic gut bacteria will be of interest, as will the gut-derived systemic metabolites. There will be a focus on aspects that influence the microbial metabotype, including; genetic factors, diet, BMI, physical activity, non-dietary xenobiotics (e.g. drugs, pollutants), oxidative stress, aging and disease.
Dr. Wendy Roslyn Russell
Guest Editors
Manuscript Submission Information
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Keywords
- microbial communities
- quantitative metabolomics
- microbial-derived gut metabolites
- microbial-derived systemic metabolites
- metabolic modelling
- LC-MS, GC-MS and NMR
- multivariate analysis; data integration
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