Advances in Iron Metabolism and Anemia
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".
Deadline for manuscript submissions: closed (15 April 2022) | Viewed by 26450
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Special Issue Editors
Interests: red blood cell membrane defects; iron metabolism; molecular genetics; hereditary anemias; cell signaling; pathophysiologic mechanisms of hereditary anemias; dehydrated hereditary stomatocytosis; PIEZO1
Special Issues, Collections and Topics in MDPI journals
2. CEINGE, Biotecnologie Avanzate, 80145 Napoli, Italy
Interests: congenital dyserythropoietic anemias; erythropoiesis; abnormal erythropoiesis; hereditary anemias; molecular genetics; genomics of hereditary anemias
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Iron is essential for hemoglobin synthesis and crucial for all cells for the production of heme and iron–sulfur clusters, which are components of the proteins/enzymes involved in vital biological processes, such as respiration, nucleic acid replication and repair, metabolic reactions and host defense. Research in this field has made great strides in the last few years and has clarified the role of iron in physiology and diseases. Iron is indispensable for life, but excess iron is toxic. The ability to accept/release electrons explains the tendency of iron to damage cell components and is the reason why body iron must be finely regulated. The disorders associated with alterations of iron metabolism span from iron overload to iron deficiency. The studies of genetic and acquired iron disorders have identified novel iron genes, proteins and pathways and revealed the essential role of the hepcidin–ferroportin axis in systemic iron homeostasis.
The aim of this issue is to achieve an overview of the diseases associated with iron metabolism alterations. We will focus on genetic conditions characterized by iron overload without anemia (hereditary hemochromatosis); iron-loading hereditary anemias (thalassemia syndromes, congenital sideroblastic anemia, congenital dyserythropoietic anemia, hypotransferrinemia, DMT1 mutations, dehydrated hereditary stomatocytosis); genetic iron deficiency (IRIDA); genetic regional iron-ferritin accumulation (hyperferritinemia-cataract syndrome, ferritinopathy); acquired iron overload (chronic blood transfusions); acquired iron-loading anemias (ringed sideroblast myelodysplastic syndrome); acquired absolute iron deficiency; acquired functional iron deficiency (anemia of inflammation). We also aim to highlight new methods allowing the detection of links between disease and iron metabolism.
Dr. Immacolata Andolfo
Dr. Roberta Russo
Guest Editors
Manuscript Submission Information
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Keywords
- iron overload
- iron deficiency
- pathogenic mechanisms of alteration of iron metabolism
- physiology of iron metabolism.
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