Insights into the Alteration of Lipid Metabolisms in Cardiometabolic Diseases
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".
Deadline for manuscript submissions: closed (15 November 2021) | Viewed by 100645
Special Issue Editor
Interests: lipids; lipidomic; lipoproteins; macrophages; cardiometabolic diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiometabolic diseases are characterized by major alterations in lipid metabolism affecting both systemic and cellular compartments. Consumption of lipid-enriched diets induces major modifications in concentration and composition of circulating lipoproteins causing dyslipidemia. Importantly, dietary lipids profoundly impact the synthesis of lipoproteins in specialized tissues as well as the complex lipid composition of lipoproteins with consequences on their biological activities. At the cellular level, dietary lipids together with the disturbed lipoprotein phenotype induce a profound change of lipid metabolism in major tissues including but not limited to liver, adipose tissue, intestine, pancreas, muscle and heart participating to their remodeling and in some cases to their metabolic activation as observed in macrophages. Such a remodeling may occur through alterations in membrane lipid structure, signaling pathways, generation of bioactive or cytotoxic lipids as well as in the capacity to handle this excess of lipids (storage vs catabolism vs recycling). All these modifications participate to the development of the spectrum of metabolic disorders including obesity, insulin resistance, diabetes, non-alcoholic fatty liver diseases and atherosclerosis contributing to cardiovascular diseases.
This special issue of Metabolites will be dedicated for publishing current advances on mechanisms underlying these alterations of the systemic and cellular lipid metabolism as well as their biological consequences in the context of cardiometabolic diseases. All the fields related to the study of lipids involving genetic/epigenetic, biochemical, molecular, cellular and omics approaches will be covered in this issue.
Dr. Wilfried Le Goff
Guest Editor
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Keywords
- Lipid
- lipidomic
- lipoprotein
- membrane
- obesity
- diabetes
- insulin resistance
- NAFLD
- atherosclerosis
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