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Metabolites
Special Issues
Metabolomics in Dietary Disease
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Metabolomics in Dietary Disease

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (15 November 2020) | Viewed by 3174

Special Issue Editor

Dr. Gerd Bobe

E-Mail Website
Guest Editor
Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
Interests: dietary disease prevention; early disease biomarkers; dietary exposure biomarkers

Special Issue Information

Dear Colleagues,

Metabolomics is an emerging analytical chemical technique that allows concomitant measurement of a large number of metabolites in biological samples. This allows description and characterization of diet-induced changes within blood, body fluids, cells, and tissues, which can be used to identify and explore metabolic pathways and molecular targets for treatment and/or prevention of dietary diseases. This Special Issue provides the readers with an overview of the history, current status, and future direction of the field. The goal will be to help readers to decide which methods will be best suited for their objective with respect to experimental design, sample extraction, biochemical analysis, quality control, data extraction and preprocessing, metabolic feature identification and structural alignment, statistical analysis, data visualization, data integration, and how those choices have or will advance interpretation of metabolomics data.

Dr. Gerd Bobe
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Metabolomics
  • Metabolomics pipelines
  • Experimental design
  • Sample preparation
  • Biochemical analysis
  • Data extraction
  • Metabolite identification
  • Statistical analysis
  • Data visualization
  • Data interpretation

Published Papers (1 paper)

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Research

21 pages, 2272 KiB  
Article
Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis
by Manuel Föcker, Alexander Cecil, Cornelia Prehn, Jerzy Adamski, Muriel Albrecht, Frederike Adams, Anke Hinney, Lars Libuda, Judith Bühlmeier, Johannes Hebebrand, Triinu Peters and Jochen Antel
Metabolites 2021, 11(1), 7; https://doi.org/10.3390/metabo11010007 - 24 Dec 2020
Cited by 8 | Viewed by 2855
Abstract
Acute anorexia nervosa (AN) constitutes an extreme physiological state. We aimed to detect state related metabolic alterations during inpatient admission and upon short- and long-term weight regain. In addition, we tested the hypothesis that metabolite concentrations adapt to those of healthy controls (HC) [...] Read more.
Acute anorexia nervosa (AN) constitutes an extreme physiological state. We aimed to detect state related metabolic alterations during inpatient admission and upon short- and long-term weight regain. In addition, we tested the hypothesis that metabolite concentrations adapt to those of healthy controls (HC) after long-term weight regain. Thirty-five female adolescents with AN and 25 female HC were recruited. Based on a targeted approach 187 metabolite concentrations were detected at inpatient admission (T0), after short-term weight recovery (T1; half of target-weight) and close to target weight (T2). Pattern hunter and time course analysis were performed. The highest number of significant differences in metabolite concentrations (N = 32) were observed between HC and T1. According to the detected main pattern, metabolite concentrations at T2 became more similar to those of HC. The course of single metabolite concentrations (e.g., glutamic acid) revealed different metabolic subtypes within the study sample. Patients with AN after short-term weight regain are in a greater “metabolic imbalance” than at starvation. After long-term weight regain, patients reach a metabolite profile similar to HC. Our results might be confounded by different metabolic subtypes of patients with AN. Full article
(This article belongs to the Special Issue Metabolomics in Dietary Disease)
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