New Pathways to Improve Muscle Metabolism and Muscle Growth

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 5220

Special Issue Editor


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Guest Editor
Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Interests: cell signaling; metabolism; endocrinology; skeletal muscle; muscle regeneration

Special Issue Information

Dear Colleagues,

This Special Issue will highlight cutting-edge advances in identifying metabolite-regulated pathways that improve the metabolism and growth of skeletal muscle. In recent years, the field of muscle biology has been revolutionized by metabolic flux analysis, identification of metabolite-sensing receptors, and the interplay between skeletal muscle-derived hormones and classical endocrine hormones in regulating muscle metabolism and growth in states of disease and healthful adaptation.

These advances enable and require interdisciplinary methods of investigation and broader thinking to view skeletal muscles as more than a force-generation machine. By doing so, we can recognize the intricate biophysical and biochemical control points within skeletal muscle that regulate muscle metabolism and growth, and in turn, the physiology of the organism.

Dr. Rebecca L. Berdeaux
Guest Editor

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Keywords

  • intermediary metabolism
  • muscle atrophy
  • muscle hypertrophy
  • metabolic flexibility
  • metabolite sensing
  • muscle-derived endocrine factors
  • cell signaling
  • obesity and diabetes
  • insulin resistance
  • lipid metabolism
  • receptors
  • mitochondrial biophysics

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Published Papers (2 papers)

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Research

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18 pages, 1751 KiB  
Article
Abscisic Acid Improves Insulin Action on Glycemia in Insulin-Deficient Mouse Models of Type 1 Diabetes
by Mirko Magnone, Sonia Spinelli, Giulia Begani, Lucrezia Guida, Laura Sturla, Laura Emionite and Elena Zocchi
Metabolites 2022, 12(6), 523; https://doi.org/10.3390/metabo12060523 - 6 Jun 2022
Cited by 8 | Viewed by 2175
Abstract
Abscisic acid (ABA), a plant hormone, has recently been shown to play a role in glycemia regulation in mammals, by stimulating insulin-independent glucose uptake and metabolism in skeletal muscle. The aim of this study was to test whether ABA could improve glycemic control [...] Read more.
Abscisic acid (ABA), a plant hormone, has recently been shown to play a role in glycemia regulation in mammals, by stimulating insulin-independent glucose uptake and metabolism in skeletal muscle. The aim of this study was to test whether ABA could improve glycemic control in a murine model of type 1 diabetes (T1D). Mice were rendered diabetic with streptozotocin and the effect of ABA administration, alone or with insulin, was tested on glycemia. Diabetic mice treated with a single oral dose of ABA and low-dose subcutaneous insulin showed a significantly reduced glycemia profile compared with controls treated with insulin alone. In diabetic mice treated for four weeks with ABA, the effect of low-dose insulin on the glycemia profile after glucose load was significantly improved, and transcription both of the insulin receptor, and of glycolytic enzymes in muscle, was increased. Moreover, a significantly increased transcription and protein expression of AMPK, PGC1-α, and GLUT4 was observed in the skeletal muscle from diabetic mice treated with ABA, compared with untreated controls. ABA supplementation in conjunction with insulin holds the promise of reducing the dose of insulin required in T1D, reducing the risk of hypoglycemia, and improving muscle insulin sensitivity and glucose consumption. Full article
(This article belongs to the Special Issue New Pathways to Improve Muscle Metabolism and Muscle Growth)
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Review

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23 pages, 3516 KiB  
Review
Protein O-GlcNAcylation in Metabolic Modulation of Skeletal Muscle: A Bright but Long Way to Go
by Yang Liu, Yajie Hu and Shize Li
Metabolites 2022, 12(10), 888; https://doi.org/10.3390/metabo12100888 - 22 Sep 2022
Cited by 1 | Viewed by 2632
Abstract
O-GlcNAcylation is an atypical, dynamic and reversible O-glycosylation that is critical and abundant in metazoan. O-GlcNAcylation coordinates and receives various signaling inputs such as nutrients and stresses, thus spatiotemporally regulating the activity, stability, localization and interaction of target proteins to [...] Read more.
O-GlcNAcylation is an atypical, dynamic and reversible O-glycosylation that is critical and abundant in metazoan. O-GlcNAcylation coordinates and receives various signaling inputs such as nutrients and stresses, thus spatiotemporally regulating the activity, stability, localization and interaction of target proteins to participate in cellular physiological functions. Our review discusses in depth the involvement of O-GlcNAcylation in the precise regulation of skeletal muscle metabolism, such as glucose homeostasis, insulin sensitivity, tricarboxylic acid cycle and mitochondrial biogenesis. The complex interaction and precise modulation of O-GlcNAcylation in these nutritional pathways of skeletal muscle also provide emerging mechanical information on how nutrients affect health, exercise and disease. Meanwhile, we explored the potential role of O-GlcNAcylation in skeletal muscle pathology and focused on its benefits in maintaining proteostasis under atrophy. In general, these understandings of O-GlcNAcylation are conducive to providing new insights into skeletal muscle (patho) physiology. Full article
(This article belongs to the Special Issue New Pathways to Improve Muscle Metabolism and Muscle Growth)
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