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Metabolites
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Nutrition during Pregnancy and Offspring Growth and Metabolism
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Nutrition during Pregnancy and Offspring Growth and Metabolism

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 9639

Special Issue Editors

Dr. Clint Lee Gray

E-Mail Website
Guest Editor
Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand
Interests: pressure myography; preterm vascular function; placenta; maternal diet; uterine environment; blastocyst development; microRNA; gene expression; Proteomics; metabolomics
Dr. Lifeng Peng

E-Mail Website
Guest Editor
School of Biological Sciences and Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand
Interests: proteomics; metabolomics; metabolic pathway analysis
Dr. Timothy Regnault

E-Mail Website
Guest Editor
Departments of Obstetrics and Gynaecology and Physiology and Pharmacology, Western University, London, ON, Canada
Interests: placental and fetal development and function, origins of adult metabolic disease; NCDs, animal/human models; PET/CT; MRI; hypoxia; oxidative stress; maternal diet
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear colleagues,

This special issue of Metabolites we aim to increase engagement and focus on the effects of a suboptimal maternal, paternal diet and early pre-natal nutrition and the transgenerational predisposition to disease. Despite DOHaD being a relatively new science there are a growing number of researchers investigating the effects of maternal and paternal health, well-being and nutrition on transgenerational predisposition to disease. Research including, but not limited to, maternal and paternal nutritional status on transgenerational health and disease, novel mechanisms of developmental programming, including metabolism, metabolic networks, mitochondrial function, general physiology. Papers addressing ethics, aspects of law for DOHaD and integrated (systemic) approach to the knowledge transfer between research, education, leading to potential evidence-based practice and policy changes are also welcome.

The primary goal of this topic is to appeal to and attract a broad range of researchers to disseminate their work and make a substantial contribution to the Developmental Origins of Health and Disease (DOHaD) science. We welcome original research articles, short reviews, systematic reviews, Perspectives and Colloquium Papers.

Dr. Clint Lee Gray
Dr. Lifeng Peng
Dr. Timothy Regnault
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Developmental programming
  • Developmental Origins of Health and Disease (DOHaD)
  • Maternal nutrition
  • Paternal nutrition
  • Fetal development
  • Placental metabolism and dysfunction
  • Metabolic pathways
  • Metabolomics
  • Lipidomics
  • Proteomics

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Published Papers (3 papers)

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17 pages, 4469 KiB  
Article
Switching to a Standard Chow Diet at Weaning Improves the Effects of Maternal and Postnatal High-Fat and High-Sucrose Diet on Cardiometabolic Health in Adult Male Mouse Offspring
by Andrea Chiñas Merlin, Kassandra Gonzalez, Sarah Mockler, Yessenia Perez, U-Ter Aondo Jia, Adam J. Chicco, Sarah L. Ullevig and Eunhee Chung
Metabolites 2022, 12(6), 563; https://doi.org/10.3390/metabo12060563 - 18 Jun 2022
Cited by 5 | Viewed by 2515
Abstract
Cardiac mitochondrial dysfunction contributes to obesity-associated heart disease. Maternal and postnatal diet plays an important role in cardiac function, yet the impacts of a mismatch between prenatal and postweaning diet on cardiometabolic function are not well understood. We tested the hypothesis that switching [...] Read more.
Cardiac mitochondrial dysfunction contributes to obesity-associated heart disease. Maternal and postnatal diet plays an important role in cardiac function, yet the impacts of a mismatch between prenatal and postweaning diet on cardiometabolic function are not well understood. We tested the hypothesis that switching to a standard chow diet after weaning would attenuate systemic metabolic disorders and cardiac and mitochondrial dysfunction associated with maternal and postnatal high-fat/high-sucrose (HFHS) diet in mice. Six-month-old male CD1 offspring from dams fed a HFHS diet and weaned to the same HFHS diet (HH) or switched to a standard chow diet (HC) were compared to offspring from dams fed a low-fat/low-sucrose diet and maintained on the same diet (LL). HC did not decrease body weight (BW) but normalized glucose tolerance, plasma cholesterol, LDL, and insulin levels compared to the HH. Systolic function indicated by the percent fractional shortening was not altered by diet. In freshly isolated cardiac mitochondria, maximal oxidative phosphorylation-linked respiratory capacity and coupling efficiency were significantly higher in the HC in the presence of fatty acid substrate compared to LL and HH, with modification of genes associated with metabolism and mitochondrial function. Switching to a standard chow diet at weaning can attenuate the deleterious effects of long-term HFHS in adult male mouse offspring. Full article
(This article belongs to the Special Issue Nutrition during Pregnancy and Offspring Growth and Metabolism)
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21 pages, 5582 KiB  
Article
Framework of Methodology to Assess the Link between A Posteriori Dietary Patterns and Nutritional Adequacy: Application to Pregnancy
by Foteini Tsakoumaki, Charikleia Kyrkou, Maria Fotiou, Aristea Dimitropoulou, Costas G. Biliaderis, Apostolos P. Athanasiadis, Georgios Menexes and Alexandra-Maria Michaelidou
Metabolites 2022, 12(5), 395; https://doi.org/10.3390/metabo12050395 - 27 Apr 2022
Cited by 2 | Viewed by 2591
Abstract
This study aimed to explore the nutritional profile of 608 women during the second trimester of pregnancy, in terms of nutrient patterns, dietary quality and nutritional adequacy. Dietary data were collected using a validated Mediterranean-oriented, culture-specific FFQ. Principal component analysis was performed on [...] Read more.
This study aimed to explore the nutritional profile of 608 women during the second trimester of pregnancy, in terms of nutrient patterns, dietary quality and nutritional adequacy. Dietary data were collected using a validated Mediterranean-oriented, culture-specific FFQ. Principal component analysis was performed on 18 energy-adjusted nutrients. Two main nutrient patterns, “plant-origin” (PLO) and “animal-origin” (ANO), were extracted. Six homogenous clusters (C) relative to nutrient patterns were obtained and analyzed through a multidimensional methodological approach. C1, C5 and C6 scored positively on PLO, while C1, C2 and C3 scored positively on ANO. When dietary quality was mapped on food choices and dietary indexes, C6 unveiled a group with a distinct image resembling the Mediterranean-type diet (MedDiet Score = 33.8). Although C1–C5 shared common dietary characteristics, their diet quality differed as reflected in the HEI-2010 (C1:79.7; C2:73.3; C3:70.9; C4:63.2; C5:76.6). The appraisal of nutritional adequacy mirrored a “nutritional-quality gradient”. A total of 50% of participants in C6 had almost 100% adequate magnesium intake, while 50% of participants in C4 had a probability of adequacy of ≤10%. Our methodological framework is efficient for assessing the link between a posteriori dietary patterns and nutritional adequacy during pregnancy. Given that macro- and micronutrient distributions may induce metabolic modifications of potential relevance to offspring’s health, public health strategies should be implemented. Full article
(This article belongs to the Special Issue Nutrition during Pregnancy and Offspring Growth and Metabolism)
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15 pages, 330 KiB  
Study Protocol
LIMIT: LIfestyle and Microbiome InTeraction Early Adiposity Rebound in Children, a Study Protocol
by Rachele De Giuseppe, Federica Loperfido, Rosa Maria Cerbo, Maria Cristina Monti, Elisa Civardi, Francesca Garofoli, Micol Angelini, Beatrice Maccarini, Eduardo Sommella, Pietro Campiglia, Laura Bertuzzo, Marcello Chieppa, Stefano Ghirardello and Hellas Cena
Metabolites 2022, 12(9), 809; https://doi.org/10.3390/metabo12090809 - 28 Aug 2022
Cited by 3 | Viewed by 3656
Abstract
Childhood obesity is a strong predictor of adult obesity with health and economic consequences for individuals and society. Adiposity rebound (AR) is a rise in the Body Mass Index occurring between 3 and 7 years. Early adiposity rebound (EAR) occurs at a median [...] Read more.
Childhood obesity is a strong predictor of adult obesity with health and economic consequences for individuals and society. Adiposity rebound (AR) is a rise in the Body Mass Index occurring between 3 and 7 years. Early adiposity rebound (EAR) occurs at a median age of 2 years and predisposes to a later onset of obesity. Since obesity has been associated with intestinal dysbiosis, we hypothesize that EAR could be related to early microbiome changes due to maternal/lifestyle changes and environmental exposures, which can increase the unhealthy consequences of childhood obesity. LIMIT is a prospective cohort study that aims at identifying the longitudinal interplay between infant gut microbiome, infant/maternal lifestyle, and environmental variables, in children with EAR vs. AR. Methods. The study evaluated 272 mother-infant pairs, enrolled at an Italian neonatal unit, at different time points (T0, at delivery; T1, 1 month; T2, 6 months; T3, 12 months; T4, 24 months; T5, 36 months after birth). The variables that were collected include maternal/infant anthropometric measurements, lifestyle habits, maternal environmental endocrine disruptor exposure, as well as infant AR. The LIMIT results will provide the basis for early identification of those maternal and infant modifiable factors on which to act for an effective and personalized prevention of childhood obesity. Full article
(This article belongs to the Special Issue Nutrition during Pregnancy and Offspring Growth and Metabolism)
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