Recent Achievements on Electrochemical Biosensors

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B1: Biosensors".

Deadline for manuscript submissions: closed (20 January 2023) | Viewed by 2605

Special Issue Editor


E-Mail Website
Guest Editor
The Chair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland
Interests: The evolutionarily directed affinity of nucleic acids and antibodies towards the corresponding analytes (complementary sequences, antigens) makes them applicable, among others, as receptors for affinity biosensor sensing layers. Molecular recognition taking place in a few nanometer interfacial space (surface/solution) translates into a very strong response of biological sensors and obtaining low detection limits or very high sensitivity of conducted analyses. Research topics include, among others, the construction and analysis of receptor layers of affinity biosensors (nucleic acids, including aptamers and antibodies) as well as the construction of ready-made sensor solutions, also on substrates manufactured using printed electronics technology. Such solutions, due to their high degree of miniaturization, possibility of simultaneous detection of several analytes, low cost or freedom of production scalability, have a high degree of applicability through integration into modern microfluidic devices and ulti
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The need for selective detection and determination of low concentrations of certain analytes in the shortest possible time of analysis has prompted continuous efforts aimed at the design and construction of new microanalytical devices. Of particular interest in this area are chemical sensors due to the possibilities they offer now and may offer in the future. Chemical sensors, along with their specific type with biological-origin components in the analyte identifying layer, i.e., so-called biosensors, are small mobile devices of simple construction and low price per unit. In this context, electrochemical detection techniques seem the most appropriate to use. This is because it is possible to analyze even the slightest changes noted in the receptor layer during analyte binding, which may in turn result in low detection limits or fast response times. Together with high selectivity secured by the biological receptor layer, these attributes make these devices particularly attractive for modern analytical methods dedicated to analyses of food products, clinically and environmentally important analytes, or the fast testing of toxic samples. Thanks to progress in the development of automation, electronics, material engineering or biomedical engineering, small and mobile analytical platforms have been constructed where (bio)sensors, especially electrochemical ones, are preferably used as detectors. Therefore, this Special Issue seeks to showcase research papers and review articles that focus on recent advances in electrochemical biosensors. 

I look forward to receiving your submissions.

Dr. Robert Ziółkowski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensor
  • nanomaterials
  • microfluidic devices
  • MEMS
  • detection techniques
  • aptamers
  • antibodies

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

10 pages, 5323 KiB  
Article
Electrochemical Sensor for Bilirubin Detection Using Paper-Based Screen-Printed Electrodes Functionalized with Silver Nanoparticles
by Nigar Anzar, Shariq Suleman, Rocky Kumar, Rachna Rawal, Chandra Shekhar Pundir, Roberto Pilloton and Jagriti Narang
Micromachines 2022, 13(11), 1845; https://doi.org/10.3390/mi13111845 - 28 Oct 2022
Cited by 14 | Viewed by 2288
Abstract
A notable diagnostic for the detection of hemolytic diseases is bilirubin, a by-product of haemoglobin breakdown. The concentration of bilirubin ranges from 0.3 to 1.9 mg in 100 mL of blood. Low blood bilirubin levels are associated with a greater risk of coronary [...] Read more.
A notable diagnostic for the detection of hemolytic diseases is bilirubin, a by-product of haemoglobin breakdown. The concentration of bilirubin ranges from 0.3 to 1.9 mg in 100 mL of blood. Low blood bilirubin levels are associated with a greater risk of coronary heart disease and anaemia. Hyperbilirubinemia results from a serum bilirubin level of more than 2.5 mg/100 mL. Therefore, it is very crucial to check the serum bilirubin level. Analytical equipment for point-of-care testing must be portable, small, and affordable. A unique method is used to detect bilirubin selectively using paper-based screen-printed carbon electrodes that were covalently linked with nanoparticles, that serves as a key biomarker for jaundice. In order to create an electrochemical biosensor, bilirubin oxidase was immobilised on electrodes modified with AgNPs. The morphology of Ag nanoparticles in terms of size and shape was determined using both UV- Vis Spectroscopy and transmission electron microscopy (TEM). The biosensor’s analytical response was assessed using potentiostat (Cyclic voltammetry (CV) and linear sweep voltammetry (LSV)). The developed paper-based sensor provided optimum feedback and a broad linear range of 1 to 9 µg/mL for bilirubin, with a lower LOD of 1 µg/mL. Through tests of bilirubin in artificial blood serum, the viability is confirmed. The method that is being used makes it possible to create and use an inexpensive, miniature electrochemical sensor. Full article
(This article belongs to the Special Issue Recent Achievements on Electrochemical Biosensors)
Show Figures

Figure 1

Back to TopTop