Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.2
3.0
Journals
Micromachines
Special Issues
Micro-/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications, 3rd Edition
share announcement

Micro-/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications, 3rd Edition

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1657

Special Issue Editors

Dr. Senhorinha de Fátima Capela Fortunas Teixeira

E-Mail Website
Guest Editor
Department of Production Systems, University of Minho, 4800-058 Guimarães, Portugal
Interests: numerical modeling and optimization; two-phase flow; CFD modelling
Special Issues, Collections and Topics in MDPI journals
Dr. Diana Pinho

E-Mail Website
Guest Editor
Center for MicroElectroMechanical Systems (CMEMS), University of Minho, Campus Azurém, 4800-058 Guimarães, Portugal
Interests: microfluidics systems; organ-on-a-chip; lab-on-a-chip biosensing; mechanical phenotyping of cells; isolation of rare cancer cells; blood flow numerical simulations and modelling; 3D manufacturing; surface modifications; biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, microfluidic, nanofluidic, and lab-on-a-chip devices have gained particular attention in biomedical applications. Due to their advantages, such as miniaturization, versatility, ease of use, cost-effectiveness, and the potential to replace animal models for drug development and testing, these devices hold tremendous potential to revolutionize the research on more effective treatments for several diseases that threaten human life. With integrated biosensors, these devices allow the development and design of micro- and nanoparticles to be studied in detail, modelling human physiology, investigating the molecular and cellular mechanisms underlying disease formation and progression, and gaining insights into the performance and long-term effects of responsive drug delivery nanocarriers.

This Special Issue seeks to gather research papers, and review articles focusing on novel microfluidic, nanofluidic and lab-on-a-chip devices for biomedical applications, addressing all steps related to fabrication, biosensor integration and development, characterization, numerical simulations and validation of the devices, optimization and, if possible, the translation of these devices from research labs to industry settings.

We look forward to receiving your submissions.

Dr. Senhorinha de Fátima Capela Fortunas Teixeira
Dr. Diana Pinho
Guest Editors

Violeta Carvalho
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micro- and nanofluidics
  • lab-on-a-chip
  • biosensing
  • nanoparticles
  • drug delivery systems
  • 3D organ models
  • nanotechnology
  • numerical simulations

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

16 pages, 5056 KiB  
Article
Prognostic Value of the Number of Circulating Tumor Cells in Patients with Metastatic Non-Small Cell Lung Cancer
by Arthur B. Volovetsky, Victoria A. Novikova, Anastasia Boloban, Aleksej S. Rzhevskiy, Alina Kapitannikova, Elena G. Ovchinnikova, Tatjana P. Klejmentjeva, Vladislav A. Grishin, Yana Pigareva, Andrei V. Zvyagin, Majid Ebrahimi Warkiani and Anna V. Maslennikova
Micromachines 2025, 16(4), 470; https://doi.org/10.3390/mi16040470 - 15 Apr 2025
Viewed by 65
Abstract
Investigating the molecular and genetic characteristics of circulating tumor cells (CTCs) presents a promising approach for personalizing treatment in patients with malignant neoplasms, given the limitations of traditional biopsy and histopathology. This study aimed to isolate, characterize, and analyze CTC dynamics in the [...] Read more.
Investigating the molecular and genetic characteristics of circulating tumor cells (CTCs) presents a promising approach for personalizing treatment in patients with malignant neoplasms, given the limitations of traditional biopsy and histopathology. This study aimed to isolate, characterize, and analyze CTC dynamics in the peripheral blood of 30 patients with metastatic lung cancer to develop criteria for treatment response and prognosis. We detected CTCs before the start of the treatment and monitored changes during treatment, correlating these with responses evaluated by standard imaging methods. A decrease in the CTCs in the course of the therapy was linked to a favorable tumor response, while the stable CTC counts indicated a lack of response and poor survival prognosis. The OS of patients was analyzed and compared with the initial number of CTCs in peripheral blood samples. The significant reductions in median OS were evident in patients with >3 total CTCs at baseline compared to those with ≤3 total CTCs (median survival 26 months, n = 10, vs. median survival 8 months, n = 19, respectively with HR = 2.6, 95% CI 1.07 to 6.4). Full article
(This article belongs to the Special Issue Micro-/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications, 3rd Edition)
►▼ Show Figures

Figure 1

14 pages, 3129 KiB  
Article
Acoustic Bubbles as Small-Scale Energy Harvesters for Implantable Medical Devices
by Wenbo Li, Anthony Mercader and Sung Kwon Cho
Micromachines 2025, 16(4), 362; https://doi.org/10.3390/mi16040362 - 21 Mar 2025
Viewed by 188
Abstract
Piezoelectric acoustic energy harvesting within the human body has traditionally faced challenges due to insufficient energy levels for biomedical applications. Existing acoustic resonators are often much larger in size, making them impractical for microscale applications. This study investigates the use of acoustically oscillated [...] Read more.
Piezoelectric acoustic energy harvesting within the human body has traditionally faced challenges due to insufficient energy levels for biomedical applications. Existing acoustic resonators are often much larger in size, making them impractical for microscale applications. This study investigates the use of acoustically oscillated microbubbles as energy-harvesting resonators. A comparative study was conducted to determine the energy harvested by a freestanding diaphragm and a diaphragm coupled with an oscillating microbubble. The experimental results demonstrated that incorporating a microbubble enabled the flexible piezoelectric diaphragm to harvest seven times more energy than the freestanding diaphragm. These findings were further validated using Laser Doppler Vibrometer (LDV) measurements and stress calculations. Additional experiments with a phantom tissue tank confirmed the feasibility of this technology for biomedical applications. The results indicate that acoustically resonating microbubbles are a promising design for microscale acoustic energy-harvesting resonators in implantable biomedical devices. Full article
(This article belongs to the Special Issue Micro-/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications, 3rd Edition)
►▼ Show Figures

Figure 1

15 pages, 4711 KiB  
Article
Biocompatible Heterogeneous Packaging and Laser-Assisted Fluid Interface Control for In Situ Sensor in Organ-on-a-Chip
by Yu-Hsuan Lin, Shing-Fung Lau, Yen-Pei Lu, Kuo-Cheng Huang, Chien-Fang Ding, Yu-Hsiang Tang and Hsin-Yi Tsai
Micromachines 2025, 16(1), 46; https://doi.org/10.3390/mi16010046 - 30 Dec 2024
Viewed by 935
Abstract
The development of bionic organ-on-a-chip technology relies heavily on advancements in in situ sensors and biochip packaging. By integrating precise biological and fluid condition sensing with microfluidics and electronic components, long-term dynamic closed-loop culture systems can be achieved. This study aims to develop [...] Read more.
The development of bionic organ-on-a-chip technology relies heavily on advancements in in situ sensors and biochip packaging. By integrating precise biological and fluid condition sensing with microfluidics and electronic components, long-term dynamic closed-loop culture systems can be achieved. This study aims to develop biocompatible heterogeneous packaging and laser surface modification techniques to enable the encapsulation of electronic components while minimizing their impact on fluid dynamics. Using a kidney-on-a-chip as a case study, a non-toxic packaging process and fluid interface control methods have been successfully developed. Experimentally, miniature pressure sensors and control circuit boards were encapsulated using parylene-C, a biocompatible material, to isolate biochemical fluids from electronic components. Ultraviolet laser processing was employed to fabricate structures on parylene-C. The results demonstrate that through precise control of processing parameters, the wettability of the material can be tuned freely within a contact angle range of 60° to 110°. Morphological observations and MTT assays confirmed that the material and the processing methods do not induce cytotoxicity. This technology will facilitate the packaging of various miniature electronic components and biochips in the future. Furthermore, laser processing enables rapid and precise control of interface conditions across different regions within the chip, demonstrating a high potential for customized mass production of biochips. The proposed innovations provide a solution for in situ sensing in organ-on-a-chip systems and advanced biochip packaging. We believe that the development of this technology is a critical step toward realizing the concept of “organ twin”. Full article
(This article belongs to the Special Issue Micro-/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications, 3rd Edition)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop