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Micromachines
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Micro-/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications, 3rd Edition
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Micro-/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications, 3rd Edition

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 862

Special Issue Editors

Dr. Senhorinha de Fátima Capela Fortunas Teixeira

E-Mail Website
Guest Editor
Department of Production Systems, University of Minho, 4800-058 Guimarães, Portugal
Interests: numerical modeling and optimization; two-phase flow; CFD modelling
Special Issues, Collections and Topics in MDPI journals
Dr. Diana Pinho

E-Mail Website
Guest Editor
1. MicroElectroMechanical Systems Research Unit (CMEMS), University of Minho, 4800-058 Guimarães, Portugal
2. LABBELS–Associate Laboratory, Braga, Portugal
Interests: biomicrofluidics; nanomedicine; microfluidic devices; organ-on-a-chip; biosensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, microfluidic, nanofluidic, and lab-on-a-chip devices have gained particular attention in biomedical applications. Due to their advantages, such as miniaturization, versatility, ease of use, cost-effectiveness, and the potential to replace animal models for drug development and testing, these devices hold tremendous potential to revolutionize the research on more effective treatments for several diseases that threaten human life. With integrated biosensors, these devices allow the development and design of micro- and nanoparticles to be studied in detail, modelling human physiology, investigating the molecular and cellular mechanisms underlying disease formation and progression, and gaining insights into the performance and long-term effects of responsive drug delivery nanocarriers.

This Special Issue seeks to gather research papers, and review articles focusing on novel microfluidic, nanofluidic and lab-on-a-chip devices for biomedical applications, addressing all steps related to fabrication, biosensor integration and development, characterization, numerical simulations and validation of the devices, optimization and, if possible, the translation of these devices from research labs to industry settings.

We look forward to receiving your submissions.

Dr. Senhorinha de Fátima Capela Fortunas Teixeira
Dr. Diana Pinho
Guest Editors

Violeta Carvalho
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micro- and nanofluidics
  • lab-on-a-chip
  • biosensing
  • nanoparticles
  • drug delivery systems
  • 3D organ models
  • nanotechnology
  • numerical simulations

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Published Papers (1 paper)

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Research

15 pages, 4711 KiB  
Article
Biocompatible Heterogeneous Packaging and Laser-Assisted Fluid Interface Control for In Situ Sensor in Organ-on-a-Chip
by Yu-Hsuan Lin, Shing-Fung Lau, Yen-Pei Lu, Kuo-Cheng Huang, Chien-Fang Ding, Yu-Hsiang Tang and Hsin-Yi Tsai
Micromachines 2025, 16(1), 46; https://doi.org/10.3390/mi16010046 - 30 Dec 2024
Viewed by 547
Abstract
The development of bionic organ-on-a-chip technology relies heavily on advancements in in situ sensors and biochip packaging. By integrating precise biological and fluid condition sensing with microfluidics and electronic components, long-term dynamic closed-loop culture systems can be achieved. This study aims to develop [...] Read more.
The development of bionic organ-on-a-chip technology relies heavily on advancements in in situ sensors and biochip packaging. By integrating precise biological and fluid condition sensing with microfluidics and electronic components, long-term dynamic closed-loop culture systems can be achieved. This study aims to develop biocompatible heterogeneous packaging and laser surface modification techniques to enable the encapsulation of electronic components while minimizing their impact on fluid dynamics. Using a kidney-on-a-chip as a case study, a non-toxic packaging process and fluid interface control methods have been successfully developed. Experimentally, miniature pressure sensors and control circuit boards were encapsulated using parylene-C, a biocompatible material, to isolate biochemical fluids from electronic components. Ultraviolet laser processing was employed to fabricate structures on parylene-C. The results demonstrate that through precise control of processing parameters, the wettability of the material can be tuned freely within a contact angle range of 60° to 110°. Morphological observations and MTT assays confirmed that the material and the processing methods do not induce cytotoxicity. This technology will facilitate the packaging of various miniature electronic components and biochips in the future. Furthermore, laser processing enables rapid and precise control of interface conditions across different regions within the chip, demonstrating a high potential for customized mass production of biochips. The proposed innovations provide a solution for in situ sensing in organ-on-a-chip systems and advanced biochip packaging. We believe that the development of this technology is a critical step toward realizing the concept of “organ twin”. Full article
(This article belongs to the Special Issue Micro-/Nanofluidic and Lab-on-a-Chip Devices for Biomedical Applications, 3rd Edition)
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