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Micromachines
Special Issues
Lab-on-a-Disk
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Lab-on-a-Disk

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "A：Physics".

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 5664

Special Issue Editor

Prof. Dr. Wim De Malsche

E-Mail Website
Guest Editor
µFlow Group, Department of Chemical Engineering, Vrije Universiteit Brussel, 1050 Brussels, Belgium
Interests: microfluidics; microreactors; mass transport enhancement; microfabrication; separations
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear colleagues,

Lab-on-a-disk technology exploits centrifugal forces by physically rotating a microfluidic substrate. As the flow is controlled through application of a given angular frequency, interfacing with pumps can be avoided and the hardware and procedures can be significantly simplified, while the cost of the devices can be greatly reduced. In recent decades, several fluidic functions such as valving, metering, multidirectional actuation and separation have been developed with great success. Thanks to the maturity of these functions and robustness of the techniques, several types of challenging clinical, analytical, and preparative applications have been successfully implemented in industrial and academic settings. With minimalistic instrument requirements, several developments focusing on point-of-care (human and animal) diagnostics have recently emerged, with the prospect to function also in conditions encountered in the poorest areas of the globe at affordable cost.  

You are cordially invited to contribute to this Special Issue of Micromachines, dedicated to “Lab-on-a-disk”, with original research articles and reviews.

In this Special Issue, the latest developments on centrifugal microfluidics will be reported. We are convinced that by bundling your latest developments in a Special Issue focusing on this exciting research area, a high impact and broad visibility in the research community will be reached.

Prof. Wim De Malsche
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lab-on-a-disk
  • centrifugal microfluidics
  • lab-on-a-CD

Published Papers (2 papers)

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Research

13 pages, 3016 KiB  
Article
Migration Behavior of Low-Density Particles in Lab-on-a-Disc Devices: Effect of Walls
by Vyacheslav R. Misko, Agata Kryj, Aude-Muriel Tamandjo Ngansop, Sogol Yazdani, Matthieu Briet, Namanya Basinda, Humphrey D. Mazigo and Wim De Malsche
Micromachines 2021, 12(9), 1032; https://doi.org/10.3390/mi12091032 - 28 Aug 2021
Cited by 3 | Viewed by 1999
Abstract
The effect of the lateral walls of a Lab-On-a-Disc device on the dynamics of a model system of particles with a density lower than that of the solvent (modelling parasites eggs) is analyzed theoretically and experimentally. In the absence of lateral walls, a [...] Read more.
The effect of the lateral walls of a Lab-On-a-Disc device on the dynamics of a model system of particles with a density lower than that of the solvent (modelling parasites eggs) is analyzed theoretically and experimentally. In the absence of lateral walls, a particle always moves in the direction of the centrifugal force, while its trajectory is deflected in the tangential direction by the inertial Coriolis and Euler forces. Lateral walls, depending on the angle forming with the radial direction, can guide the particle either in the same or in the opposite direction to the centrifugal force, thus resulting in unusual particle trajectories including zig-zag or backwards particle motion. The effect is pronounced in the case of short operation times when the acceleration of the angular rotation, and thus the Euler force, is considerable. The predicted unusual motion is demonstrated by numerically solving the equation of motion in the presence of lateral walls and verified in the experiment with particles of density lower than that of the solvent. Our analysis is useful for design and operational considerations of Lab-On-a-Disc devices aiming for or involving (bio)particle handling. Full article
(This article belongs to the Special Issue Lab-on-a-Disk)
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Graphical abstract

23 pages, 24801 KiB  
Article
Secure Air Traffic Control at the Hub of Multiplexing on the Centrifugo-Pneumatic Lab-on-a-Disc Platform
by Jens Ducrée
Micromachines 2021, 12(6), 700; https://doi.org/10.3390/mi12060700 - 15 Jun 2021
Cited by 9 | Viewed by 2976
Abstract
Fluidic larger-scale integration (LSI) resides at the heart of comprehensive sample-to-answer automation and parallelization of assay panels for frequent and ubiquitous bioanalytical testing in decentralized point-of-use/point-of-care settings. This paper develops a novel “digital twin” strategy with an emphasis on rotational, centrifugo-pneumatic flow control. [...] Read more.
Fluidic larger-scale integration (LSI) resides at the heart of comprehensive sample-to-answer automation and parallelization of assay panels for frequent and ubiquitous bioanalytical testing in decentralized point-of-use/point-of-care settings. This paper develops a novel “digital twin” strategy with an emphasis on rotational, centrifugo-pneumatic flow control. The underlying model systematically connects retention rates of rotationally actuated valves as a key element of LSI to experimental input parameters; for the first time, the concept of band widths in frequency space as the decisive quantity characterizing operational robustness is introduced, a set of quantitative performance metrics guiding algorithmic optimization of disc layouts is defined, and the engineering principles of advanced, logical flow control and timing are elucidated. Overall, the digital twin enables efficient design for automating multiplexed bioassay protocols on such “Lab-on-a-Disc” (LoaD) systems featuring high packing density, reliability, configurability, modularity, and manufacturability to eventually minimize cost, time, and risk of development and production. Full article
(This article belongs to the Special Issue Lab-on-a-Disk)
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