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Micromachines
Special Issues
Recent Progress in Micropumps
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Recent Progress in Micropumps

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 9722

Special Issue Editor

Dr. Jr-Lung Lin

E-Mail Website
Guest Editor
Department of Mechanical and Automation Engineering, I-Shou University, Kaohsiung 84001, Taiwan
Interests: microfluidics; BioMEMS; BioNEMS; biofluids

Special Issue Information

 Dear Colleagues,

“Recent Progress in Micropumps” is a Special Issue of Micromachines aiming to exchange state-of-the-art research ideas related to recent developments and applications of micropumps. With the history of micropump research, the actuation design and fabrication technique of micropumps have gone through a spectrum of technologies and materials and, as we know, the spectrum of fabrication materials and associated fabrication processes are extremely broad. Similarly, the potential applications of micropumps have multiplied from systems for precision drug delivery and chemical analysis to the high throughput of ventricular assist devices.

Accordingly, the main objective of this Special Issue is to provide an opportunity to share and discuss theoretical science, numerical models, fabrication developments, and novel applications of micropumps. We welcome contributions describing new research and developments concerning micropumps. This Special Issue will take into consideration the publication of research or review articles addressing recent discoveries and developments in micropumps. These papers will hopefully bring out fundamental insights and more innovative ideas in this field.

Dr. Jr-Lung Lin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micropumps
  • drug delivery
  • actuation design
  • ventricular assist devices
  • novel applications

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Published Papers (5 papers)

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Research

13 pages, 4447 KiB  
Article
Film-Shaped Self-Powered Electro-Osmotic Micropump Array
by Toshiro Yamanaka and Fumihito Arai
Micromachines 2023, 14(4), 785; https://doi.org/10.3390/mi14040785 - 31 Mar 2023
Cited by 1 | Viewed by 1536
Abstract
This paper reports a new concept of a film-shaped micropump array for biomedical perfusion. The detailed concept, design, fabrication process, and performance evaluation using prototypes are described. In this micropump array, an open circuit potential (OCP) is generated by a planar biofuel cell [...] Read more.
This paper reports a new concept of a film-shaped micropump array for biomedical perfusion. The detailed concept, design, fabrication process, and performance evaluation using prototypes are described. In this micropump array, an open circuit potential (OCP) is generated by a planar biofuel cell (BFC), which in turn generates electro-osmotic flows (EOFs) in multiple through-holes arranged perpendicular to the micropump plane. The micropump array is thin and wireless, so it can be cut like postage stamps, easily installed in any small location, and can act as a planar micropump in solutions containing the biofuels glucose and oxygen. Perfusion at local sites are difficult with conventional techniques using multiple separate components such as micropumps and energy sources. This micropump array is expected to be applied to the perfusion of biological fluids in small locations near or inside cultured cells, cultured tissues, living organisms, and so on. Full article
(This article belongs to the Special Issue Recent Progress in Micropumps)
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15 pages, 38087 KiB  
Article
Monolithically 3D-Printed Microfluidics with Embedded µTesla Pump
by Kai Duan, Mohamad Orabi, Alexus Warchock, Zaynab Al-Akraa, Zeinab Ajami, Tae-Hwa Chun and Joe F. Lo
Micromachines 2023, 14(2), 237; https://doi.org/10.3390/mi14020237 - 17 Jan 2023
Cited by 2 | Viewed by 2443
Abstract
Microfluidics has earned a reputation for providing numerous transformative but disconnected devices and techniques. Active research seeks to address this challenge by integrating microfluidic components, including embedded miniature pumps. However, a significant portion of existing microfluidic integration relies on the time-consuming manual fabrication [...] Read more.
Microfluidics has earned a reputation for providing numerous transformative but disconnected devices and techniques. Active research seeks to address this challenge by integrating microfluidic components, including embedded miniature pumps. However, a significant portion of existing microfluidic integration relies on the time-consuming manual fabrication that introduces device variations. We put forward a framework for solving this disconnect by combining new pumping mechanics and 3D printing to demonstrate several novel, integrated and wirelessly driven microfluidics. First, we characterized the simplicity and performance of printed microfluidics with a minimum feature size of 100 µm. Next, we integrated a microtesla (µTesla) pump to provide non-pulsatile flow with reduced shear stress on beta cells cultured on-chip. Lastly, the integration of radio frequency (RF) device and a hobby-grade brushless motor completed a self-enclosed platform that can be remotely controlled without wires. Our study shows how new physics and 3D printing approaches not only provide better integration but also enable novel cell-based studies to advance microfluidic research. Full article
(This article belongs to the Special Issue Recent Progress in Micropumps)
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20 pages, 5135 KiB  
Article
A Novel Integrated Transdermal Drug Delivery System with Micropump and Microneedle Made from Polymers
by Ajay Prabhakar Attiguppe, Dhiman Chatterjee and Amitava DasGupta
Micromachines 2023, 14(1), 71; https://doi.org/10.3390/mi14010071 - 27 Dec 2022
Cited by 2 | Viewed by 2036
Abstract
Transdermal drug delivery (TDD), which enables targeted delivery with microdosing possibilities, has seen much progress in the past few years. This allows medical professionals to create bespoke treatment regimens and improve drug adherence through real-time monitoring. TDD also increases the effectiveness of the [...] Read more.
Transdermal drug delivery (TDD), which enables targeted delivery with microdosing possibilities, has seen much progress in the past few years. This allows medical professionals to create bespoke treatment regimens and improve drug adherence through real-time monitoring. TDD also increases the effectiveness of the drugs in much smaller quantities. The use of polymers in the drug delivery field is on the rise owing to their low cost, scalability and ease of manufacture along with drug and bio-compatibility. In this work, we present the design, development and characterization of a polymer-based TDD platform fabricated using additive manufacturing technologies. The system consists of a polymer based micropump integrated with a drug reservoir fabricated by 3D printing and a polymer hollow microneedle array fabricated using photolithography. To the best of our knowledge, we present the fabrication and characterization of a 3D-printed piezoelectrically actuated non-planar valveless micropump and reservoir integrated with a polymer hollow microneedle array for the first time. The integrated system is capable of delivering water at a maximum flow rate of 1.03 mL/min and shows a maximum backpressure of 1.37 kPa while consuming only 400 mW. The system has the least number of moving parts. It can be easily fabricated using additive manufacturing technologies, and it is found to be suitable for drug delivery applications. Full article
(This article belongs to the Special Issue Recent Progress in Micropumps)
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15 pages, 4391 KiB  
Article
Force and Velocity Analysis of Particles Manipulated by Toroidal Vortex on Optoelectrokinetic Microfluidic Platform
by Sheng-Jie Zhang, Zong-Rui Yang and Ju-Nan Kuo
Micromachines 2022, 13(12), 2245; https://doi.org/10.3390/mi13122245 - 17 Dec 2022
Cited by 1 | Viewed by 1529
Abstract
The rapid electrokinetic patterning (REP) technique has been demonstrated to enable dynamic particle manipulation in biomedical applications. Previous studies on REP have generally considered particles with a size less than 5 μm. In this study, a REP platform was used to manipulate polystyrene [...] Read more.
The rapid electrokinetic patterning (REP) technique has been demonstrated to enable dynamic particle manipulation in biomedical applications. Previous studies on REP have generally considered particles with a size less than 5 μm. In this study, a REP platform was used to manipulate polystyrene particles with a size of 3~11 μm in a microfluidic channel sandwiched between two ITO conductive glass plates. The effects of the synergy force produced by the REP electrothermal vortex on the particle motion were investigated numerically for fixed values of the laser power, AC driving voltage, and AC driving frequency, respectively. The simulation results showed that the particles were subject to a competition effect between the drag force produced by the toroidal vortex, which prompted the particles to recirculate in the bulk flow adjacent to the laser illumination spot on the lower electrode, and the trapping force produced by the particle and electrode interactions, which prompted the particles to aggregate in clusters on the surface of the illuminated spot. The experimental results showed that as the laser power increased, the toroidal flow range over which the particles circulated in the bulk flow increased, while the cluster range over which the particles were trapped on the electrode surface reduced. The results additionally showed that the particle velocity increased with an increasing laser power, particularly for particles with a smaller size. The excitation frequency at which the particles were trapped on the illuminated hot-spot reduced as the particle size increased. The force and velocity of polystyrene particles by the REP toroidal vortex has implications for further investigating the motion behavior at the biological cell level. Full article
(This article belongs to the Special Issue Recent Progress in Micropumps)
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14 pages, 4968 KiB  
Article
Characterization of a Droplet Containing the Clustered Magnetic Beads Manipulation by Magnetically Actuated Chips
by Sheng-Huang Yen, Pei-Chieh Chin, Jun-Yu Hsu and Jr-Lung Lin
Micromachines 2022, 13(10), 1622; https://doi.org/10.3390/mi13101622 - 28 Sep 2022
Cited by 1 | Viewed by 1474
Abstract
A magnetically actuated chip was successfully developed in this study to perform the purpose of transportation for a droplet containing clustered magnetic beads. The magnetic field gradient is generated by the chip of the two-layer 4 × 4 array micro-coils, which was commercially [...] Read more.
A magnetically actuated chip was successfully developed in this study to perform the purpose of transportation for a droplet containing clustered magnetic beads. The magnetic field gradient is generated by the chip of the two-layer 4 × 4 array micro-coils, which was commercially fabricated by printing circuit board (PCB) technology. A numerical model was first established to investigate the magnetic field and thermal field for such a micro-coil. Consequently, the numerical simulations were in reasonable agreement with the experimental results. Moreover, a theoretical analysis was derived to predict the dynamic behaviors of the droplets. This analysis will offer the optimal operation for such a magnetically actuated chip. This study aims to successfully implement the concept of “digital microfluidics” in “point-of-care testing” (POCT). In the future, the micro-coil chip will be of substantial benefit to genetic analysis and infectious disease detection. Full article
(This article belongs to the Special Issue Recent Progress in Micropumps)
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