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Micromachines
Special Issues
Hybrid Materials for Advanced Sensing and Controlled Release Applications
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Hybrid Materials for Advanced Sensing and Controlled Release Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "C：Chemistry".

Deadline for manuscript submissions: closed (1 August 2021) | Viewed by 7101

Special Issue Editor

Dr. Estela Climent

E-Mail Website
Guest Editor
Department 1 Analytical Chemistry; Reference Materials, Bundesanstalt für Materialforschung und -prüfung (BAM), Berlin, Germany
Interests: design and synthesis of hybrid materials for controlled release, drug delivery and sensing applications; development of rapid tests, by combination of the synthesis of hybrid materials for the detection of certain substances of interest and their incorporation into several platforms for on-site sensing applications

Special Issue Information

Dear Colleagues,

Among the large number of approximations toward the development of new smart materials, one particularly tempting one is the possibility to create stimuli-responsive materials able to react to environmental changes and/or to the presence of certain analytes, having, as a result, the design of nanocontainers able to deal with cargo delivery under controlled conditions. Traditional delivery systems rely on simple diffusion-controlled processes or on the degradation of the carrier material, through the employment of microcapsules, micelles, vesicles, or liposomes. As an alternative, silica mesoporous gated materials, which control the delivery of the cargo by an external stimulus or in the presence of certain molecules, have also been reported. These materials are comprised of a suitable inorganic support, that includes cargo molecules in the inner of the pores that are able to be delivered, and certain (bio)molecular entities, usually grafted on the external surface, which are responsible for the delivery of the cargo from the pores to the solution, upon a stimulus application, or in the presence of a certain molecule. Most of the reported gated materials have been designed toward the development of advanced drug delivery systems. However, the use of gated hybrid materials for sensing purposes is an attractive approach for the development of new sensing materials, since a few target molecules can induce the release of many indicators, obtaining, as a result, a strong signal amplification.

Taking in mind these concepts, the aim of this Special Issue is to highlight recent advances in all aspects relevant to hybrid delivery systems, for controlled release, and for sensing applications, with a focus on design, synthesis and performance, and their implementation into different platforms for on-site sensing applications. For that purpose, scientists are encouraged to contribute their research to this Special Issue of Micromachines, dedicated to the development of Hybrid Materials for Advanced Sensing and Controlled Release Applications.

Dr. Estela Climent
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Hybrid materials
  • Nanocontainers
  • Gated hybrid materials
  • Advanced drug delivery systems
  • Targeted delivery
  • Controlled release applications
  • Hybrid materials for sensing

Published Papers (3 papers)

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Research

12 pages, 2414 KiB  
Article
4-Nitrophenol-Loaded Magnetic Mesoporous Silica Hybrid Materials for Spectrometric Aptasensing of Carcinoembryonic Antigen
by Jin Zhang and Dianping Tang
Micromachines 2021, 12(10), 1138; https://doi.org/10.3390/mi12101138 - 22 Sep 2021
Cited by 1 | Viewed by 1537
Abstract
Aptamer- or antibody-based sensing protocols have been reported for detecting carcinoembryonic antigen (CEA), but most exhibit complicated procedures or multiple reactions. In this work, we developed a one-step aptasensing protocol for the spectrometric determination of CEA based on 4-nitrophenol (4-NP)-loaded magnetic mesoporous silica [...] Read more.
Aptamer- or antibody-based sensing protocols have been reported for detecting carcinoembryonic antigen (CEA), but most exhibit complicated procedures or multiple reactions. In this work, we developed a one-step aptasensing protocol for the spectrometric determination of CEA based on 4-nitrophenol (4-NP)-loaded magnetic mesoporous silica nanohybrids (MMSNs) for bioresponsive controlled-release applications. To fabricate such a responsive–controlled sensing system, single-stranded complementary oligonucleotides relative to the CEA-specific aptamer were first modified on the aminated MMSN. Thereafter, 4-NP molecules blocked the pores with the assistance of the aptamers via a hybridization reaction. The introduced target CEA specifically reacted with the hybridized aptamer, thus detaching from the MMSN to open the gate. The loaded 4-NP molecules were released from the pores, as determined using ultraviolet–visible (UV–vis) absorption spectroscopy after magnetic separation. Under optimum conditions, the absorbance increased with an increase in the target CEA in the sample and exhibited a good linear relationship within the dynamic range of 0.1–100 ng mL−1, with a detection limit of 46 pg mL−1. Moreover, this system also displayed high specificity, good reproducibility, and acceptable accuracy for analyzing human serum specimens, in comparison with a commercialized human CEA-enzyme-linked immunosorbent assay (ELISA) kit. Full article
(This article belongs to the Special Issue Hybrid Materials for Advanced Sensing and Controlled Release Applications)
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10 pages, 2064 KiB  
Article
Highly Sensitive Detection for Mercury Ions Using Graphene Oxide (GO) Sensors
by Lei Liu, Haixia Shi, Raoqi Li, Cheng Liu, Jia Cheng and Li Gao
Micromachines 2021, 12(9), 1070; https://doi.org/10.3390/mi12091070 - 2 Sep 2021
Cited by 1 | Viewed by 1980
Abstract
The mercury ion (Hg2+) is one of the heavy metal ions, and its presence in trace amounts can cause physiological damage to an organism. Traditional methods of Hg2+ detection have been useful but have also had numerous limitations and challenges, [...] Read more.
The mercury ion (Hg2+) is one of the heavy metal ions, and its presence in trace amounts can cause physiological damage to an organism. Traditional methods of Hg2+ detection have been useful but have also had numerous limitations and challenges, and as a result, it is important to design new and sophisticated methods that can aid in the detection of Hg2+. In this paper, two fluorescent dyes, carboxyfluorescein (FAM) and SYBR Green I, were used to label and intercalate DNA probes immobilized on the surface of graphene oxide (GO) for sensors to detect Hg2+. FAM and SYBR Green I dye share close excitation and emission wavelength spectra, which can promote and amplify the detection of signals, and also increase the limit of detection (LOD). The results showed that the limit of detection in this method was 0.53 nM. Moreover, when the sensors with double amino groups on the surface of GO were carried out to detect Hg2+, a limit of detection was improved to 0.43 nM. The sensors were then applied in the real sample. The results show that this method has a promising potential in Hg2+ detection. Full article
(This article belongs to the Special Issue Hybrid Materials for Advanced Sensing and Controlled Release Applications)
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18 pages, 2364 KiB  
Article
Loading and Release of Charged and Neutral Fluorescent Dyes into and from Mesoporous Materials: A Key Role for Sensing Applications
by Estela Climent, Mandy Hecht and Knut Rurack
Micromachines 2021, 12(3), 249; https://doi.org/10.3390/mi12030249 - 28 Feb 2021
Cited by 4 | Viewed by 2629
Abstract
The aim of this study is to determine the efficiency of loading and release of several zwitterionic, neutral, anionic and cationic dyes into/from mesoporous nanoparticles to find the optimum loading and release conditions for their application in detection protocols. The loading is carried [...] Read more.
The aim of this study is to determine the efficiency of loading and release of several zwitterionic, neutral, anionic and cationic dyes into/from mesoporous nanoparticles to find the optimum loading and release conditions for their application in detection protocols. The loading is carried out for MCM-41 type silica supports suspended in phosphate-buffered saline (PBS) buffer (pH 7.4) or in acetonitrile, involving the dyes (rhodamine B chloride, rhodamine 101 chloride, rhodamine 101 perchlorate, rhodamine 101 inner salt, meso-(4-hydroxyphenyl)-boron–dipyrromethene (BODIPY), sulforhodamine B sodium salt and fluorescein 27). As a general trend, rhodamine-based dyes are loaded with higher efficiency, when compared with BODIPY and fluorescein dyes. Between the rhodamine-based dyes, their charge and the solvent in which the loading process is carried out play important roles for the amount of cargo that can be loaded into the materials. The delivery experiments carried out in PBS buffer at pH 7.4 reveal for all the materials that anionic dyes are more efficiently released compared to their neutral or cationic counterparts. The overall best performance is achieved with the negatively charged sulforhodamine B dye in acetonitrile. This material also shows a high delivery degree in PBS buffer. Full article
(This article belongs to the Special Issue Hybrid Materials for Advanced Sensing and Controlled Release Applications)
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