The Microbiome of the Urinary Tract: A Balance between Eubiosis and Dysbiosis

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 15 February 2025 | Viewed by 605

Special Issue Editors


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Guest Editor
Third Department of Urology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece
Interests: urinary tract infection; eubisosis and dysbiosis; urology

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Guest Editor Assistant
Third Department of Urology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece
Interests: prostate infection; urinary tract infection

Special Issue Information

Dear Colleagues,

Recent advances in the field of microbial analysis have led to the detection of a resident microbial community in the human urinary tract (UT). Additionally, recent scientific discoveries have identified various bacteria and species that colonize the urinary tract and comprise a core urinary microbiome. However, the role of the UT’s microbiome in the advancement of urinary tract infections (UTI) and recurrent UTI (rUTI) pathobiology is not yet clearly understood. Furthermore, studies in the literature have identified infections of the UT by rare bacteria, which usually do not cause infection. Thus, the identification of a typical microbiome and rare bacteria, both in the eubiosis and dysbiosis of the UT, could shed light on the pathophysiological mechanisms necessary for the development of UTIs. The aim of this Special Issue, therefore, is to identify the typical microbiome of the UT and to recognize rare bacteria that could colonize the UT in order to identify the pathophysiological mechanisms needed for the development of UTIs.

Prof. Dr. Michael Chrisofos
Guest Editor

Dr. Ilias Giannakodimos
Guest Editor Assistant

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Keywords

  • microbiome
  • urinary tract infections
  • eubiosis and dysbiosis

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Published Papers (1 paper)

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Review

9 pages, 841 KiB  
Review
Renal Actinomycosis in Humans—A Narrative Review
by Ilias Giannakodimos, Afroditi Ziogou, Alexios Giannakodimos, Evangelia Mitakidi, Aris Kaltsas, Zisis Kratiras and Michael Chrisofos
Microorganisms 2024, 12(9), 1922; https://doi.org/10.3390/microorganisms12091922 - 21 Sep 2024
Viewed by 447
Abstract
Actinomycosis of the kidney is extremely rare, with only a few cases reported in the literature. This rare entity usually presents with common clinical manifestations and non-specific imaging findings, thus rendering its diagnosis extremely challenging. According to case reports published in the literature, [...] Read more.
Actinomycosis of the kidney is extremely rare, with only a few cases reported in the literature. This rare entity usually presents with common clinical manifestations and non-specific imaging findings, thus rendering its diagnosis extremely challenging. According to case reports published in the literature, fever was present in the majority of cases (56.25%). Several risk factors have been related to the development of renal actinomycosis, including a history of urogenital surgery, urolithiasis, or urogenital cancer. Initial diagnostic investigation consists of abdominal ultrasonography (15 patients, 46.88%) and abdominal computed tomography (23 patients, 48.15%). Regarding therapeutic approach, 5 patients (16.67%) received only antibiotic treatment, 5 patients (16.67%) underwent surgery, and 20 patients (66.67%) received both antibiotic and surgical treatment. Accurate diagnosis relies on the clinician’s high index of suspicion and is ultimately confirmed through histological examination or cultures, obtained either preoperatively via biopsies or postoperatively after surgical removal of the infected kidney. To our knowledge, this is the first narrative review of the literature that collects knowledge concerning infection of UUT induced by dysbiosis of actinomycosis species. The aim of this narrative review was to systematically search the literature on primary renal actinomycosis, highlighting the diagnostic approach and treatment strategies for the management of this rare entity. Full article
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