Human Papillomavirus Infections in Public Health and Pathology

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Public Health Microbiology".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 3051

Special Issue Editors


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Guest Editor
Department of Medical Technology, Faculty of Health Sciences, Kyorin University, Mitaka, Japan
Interests: human papillomavirus; pathology/cytopathology; public health

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Guest Editor
Department of Health Science, Gunma Paz University Graduate School, Takasaki, Japan
Interests: human papillomavirus; pathology/cytopathology; public health

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Guest Editor
Department of Health Science, Gunma Paz University Graduate School, Takasaki, Japan
Interests: viruses; evolution/molecular epidemiology; public health
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Special Issue Information

Dear Colleagues,

It is widely understood that the human papillomavirus (HPV) is a major cause of cervical cancer, resulting in a serious disease burden worldwide in terms of public health. Many previous reports have suggested that HPVs be classified into numerous genotypes based on the phylogenetic analyses. They may be further distinguished by the distinct carcinogenic pathogenicities exhibited in cervical tissues, although the reason for this occurrence is not known. Moreover, longitudinally pathological/cytopathological findings have suggested that HPV infections can induce various morphologically benign and malignant changes in cervical and vaginal cells. However, these changes have not been adequately elucidated. Advanced molecular epidemiological and cytopathological findings may contribute to solving these unknown issues. In light of these circumstances, and in order to gain a better understanding of HPV infections, pathology, and public health, this Special Issue will publish research molecular epidemiology/evolution and pathology/cytopathology based on the application of advanced technologies to sophisticated genomics, bioinformatics, and molecular biology.

Prof. Dr. Mistsuaki Okodo
Prof. Dr. Kaori Okayama
Prof. Dr. Hirokazu Kimura
Guest Editors

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Keywords

  • human papillomavirus
  • carcinogenesis
  • pathology/cytopathology
  • molecular epidemiology/evolution
  • genomics/bioinformatics

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Published Papers (2 papers)

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Research

10 pages, 775 KiB  
Article
Treatment with Epigallocatechin Gallate, Folic Acid, Vitamin B12, and Hyaluronic Acid Decreases HPV Positivity in Women Attending Regional Screening in Puglia
by Andrea Tinelli, Sarah Gustapane, Martina Licchelli, Anna Chiara Coluccia, Gaetano Panese, Sara Proietti and Riccardo Gambioli
Microorganisms 2024, 12(9), 1897; https://doi.org/10.3390/microorganisms12091897 - 14 Sep 2024
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Abstract
Human Papillomavirus (HPV) infection represents a global health concern. HPV infects the mucosa, particularly in the uterine cervix, where it may establish a persistent infection, exposing women to a risk of developing cancer. The available treatments include surgery or topic solutions, while a [...] Read more.
Human Papillomavirus (HPV) infection represents a global health concern. HPV infects the mucosa, particularly in the uterine cervix, where it may establish a persistent infection, exposing women to a risk of developing cancer. The available treatments include surgery or topic solutions, while a systemic treatment is still unavailable. In recent years, natural molecules such as epigallocatechin gallate (EGCG), folic acid (FA), vitamin B12, and hyaluronic acid (HA) gained importance as innovative therapies for HPV. We enrolled 163 women with a positive HPV DNA test or previous history of HPV infections, and a PAP test indicating LSIL/AGUS/ASCUS cytology. The patients in the treatment group (n = 86) received an oral combination of EGCG 200 mg, FA 400 µg, vitamin B12 1 mg, and HA 50 mg (1 cps/day) for 3 months (T1), while the control group (n = 77) underwent standard clinical surveillance. Both groups repeated a PAP test and an HPV DNA test after 3 (T1) months, and another PAP test after 6 months (T2) as a follow up. The treatment group experienced a significant reduction in HPV positivity at T1 compared to the control group. Moreover, the treatment group exhibited an improvement in cervical lesions either at T1 (p < 0.0001) or T2 (p < 0.00001). Full article
(This article belongs to the Special Issue Human Papillomavirus Infections in Public Health and Pathology)
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16 pages, 2621 KiB  
Article
Impact of Ascending HPV Infection on Colorectal Cancer Risk: Evidence from a Nationwide Study
by Pin-Ho Pan, Ci-Wen Luo, Wen-Chien Ting, Bei-Hao Shiu, Jing-Yang Huang, Stella Chin-Shaw Tsai and Frank Cheau-Feng Lin
Microorganisms 2024, 12(9), 1746; https://doi.org/10.3390/microorganisms12091746 - 23 Aug 2024
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Abstract
Colorectal cancer (CRC) is a prevalent and escalating health issue in Taiwan. This nationwide study delves into the relationship between Human Papillomavirus (HPV) infection and CRC risk, employing population datasets from 2007 to 2017. Cox regression analyses revealed a statistically significant hazard ratio [...] Read more.
Colorectal cancer (CRC) is a prevalent and escalating health issue in Taiwan. This nationwide study delves into the relationship between Human Papillomavirus (HPV) infection and CRC risk, employing population datasets from 2007 to 2017. Cox regression analyses revealed a statistically significant hazard ratio (HR) of 1.73 (95% CI: 1.63–1.83) for CRC in HPV-positive patients, indicating a considerably elevated risk compared to non-infected individuals. Further, stratification by sex showed males with HPV have a higher CRC risk (HR = 1.49, 95% CI: 1.40–1.58) compared to females. Age-related analysis uncovered a progressive increase in CRC risk with advancing age (HR = 34.69 for over 80 years). The study of specific CRC subtypes showed varying risks: HR = 1.74 for the colon, HR = 1.64 for the rectum, and a notably higher HR = 4.72 for the anus. Comorbid conditions such as hypertension (HR = 1.26), diabetes mellitus (HR = 1.32), and abnormal liver function (HR = 1.18) also correlate with significantly increased CRC risks. These findings suggest that HPV is a significant risk factor for CRC, with disparities in risk based on anatomical location, demographic characteristics, and comorbidities, highlighting the need for intervention strategies and targeted prevention. Full article
(This article belongs to the Special Issue Human Papillomavirus Infections in Public Health and Pathology)
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