Research Advances in Dengue Virus

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: closed (30 September 2020)

Special Issue Editors


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Guest Editor
Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany
Interests: neglected tropical diseases; dengue fever

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Guest Editor
Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany
Interests: dengue; arboviral diseases

Special Issue Information

Dear Colleagues,

Dengue continues to be a neglected tropical disease (NTD), with the typical features of an NTD. Although the research landscape of dengue has changed since the WHO/TDR publication describing dengue research in 2006, many issues still remain, and other topics became more relevant. This Issue has the aim to describe the research landscape and to identify gaps for future research. Contributions are encouraged in topics including but not limited to the following:

  • Epidemiology/burden of disease, early warning;
  • Diagnosis;
  • Clinical management;
  • Vector control;
  • Drugs and vaccine;
  • Determinants;
  • Pathogenesis.

Dr. Olaf Horstick
Dr. Silvia Runge-Ranzinger
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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14 pages, 1762 KiB  
Article
Full-Length Genome and Partial Viral Genes Phylogenetic and Geographical Analysis of Dengue Serotype 3 Isolates
by Muhammad Amir, Abrar Hussain, Muhammad Asif, Sagheer Ahmed, Hina Alam, Marius Alexandru Moga, Maria Elena Cocuz, Luigi Marceanu and Alexandru Blidaru
Microorganisms 2021, 9(2), 323; https://doi.org/10.3390/microorganisms9020323 - 4 Feb 2021
Cited by 6 | Viewed by 2746
Abstract
Dengue fever is among the most common vector-borne diseases. Dengue virus (DENV), responsible for dengue fever as well as dengue hemorrhagic fever, belongs to the genus flavivirus and family Flaviviridae. Flaviviruses infect various vertebrate species and arthropods and are also responsible for diseases [...] Read more.
Dengue fever is among the most common vector-borne diseases. Dengue virus (DENV), responsible for dengue fever as well as dengue hemorrhagic fever, belongs to the genus flavivirus and family Flaviviridae. Flaviviruses infect various vertebrate species and arthropods and are also responsible for diseases in birds, wild animals, and primates. DENV consists of a single-stranded, positive-sense RNA genome ~11 kb in size. Complete genome and partial gene sequences of geographically distinct DENV-3 strains were retrieved from the GenBank database. The evolutionary divergence of the 33 whole-genome and individual gene sequences of the nucleotides and amino acids of DENV-3 strains were generated with the maximum likelihood (ML) and Bayesian phylogenetic study (BEAST) methods using the MEGA 7 software. The genome size varied from 10,484 to 10,724 nucleotides among the strains with distinct geographical backgrounds belonging to Central America, South-Central Asia, and Eastern Asia. A phylogenetic analysis of the nucleotide and amino acid sequences of these DENV-3 isolates revealed extensive differences in the topologies due to PrM/M, NS1, NS2B, and NS3 genes. These results suggest substantial variation in the evolutionary pathways of the studied genes and genomes. Full article
(This article belongs to the Special Issue Research Advances in Dengue Virus)
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Review

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16 pages, 1311 KiB  
Review
Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target
by Yen-Chung Lai, Chiao-Hsuan Chao and Trai-Ming Yeh
Microorganisms 2020, 8(6), 891; https://doi.org/10.3390/microorganisms8060891 - 12 Jun 2020
Cited by 7 | Viewed by 11843
Abstract
Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection and can lead to severe dengue hemorrhagic fever (DHF) and even life-threatening dengue shock syndrome (DSS). Although the cytokine storm has been revealed as a critical factor in dengue disease, the limited [...] Read more.
Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection and can lead to severe dengue hemorrhagic fever (DHF) and even life-threatening dengue shock syndrome (DSS). Although the cytokine storm has been revealed as a critical factor in dengue disease, the limited understanding of dengue immunopathogenesis hinders the development of effective treatments. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that mediates diverse immune responses, and the serum level of MIF positively correlates with disease severity in patients with dengue. MIF is involved in DENV replication and many pathological changes, such as vascular leakage, during DENV infection. In this paper, the pathogenic roles of MIF and the regulation of MIF secretion during DENV infection are reviewed. Furthermore, whether MIF is a potential therapeutic target against DENV infection is also discussed. Full article
(This article belongs to the Special Issue Research Advances in Dengue Virus)
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