Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.4
4.1
Journals
Microorganisms
Special Issues
The New Advance on Disinfectant of Virus and Microorganisms
share announcement

The New Advance on Disinfectant of Virus and Microorganisms

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbial Biotechnology".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 19257

Special Issue Editor

Prof. Dr. Takashi Onodera

E-Mail Website
Guest Editor
Laboratory of Environmental Science for Sustainable Development, Department of Veterynary Medical Science, Research Center for Food Safety, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Interests: virology; immunology; prions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Nanomaterials is used for disease diagnosis to develop simpler, cheaper, and faster methods. Nanomaterials have the ability to prevent viral contamination by air and contact with contaminated surfaces and have the ability to sterilize protective equipment especially in hospital settings. Creating self-disinfeting surfaces is another strategy to prevent the spread of COVID-19. There are several products made of nanocomposites that have antimicrobial activities and used in the disinfection of surfaces. CAC-717 is a new disinfectant consisting of calcium bicarbonate mesoscopic crystals that are a compound containing mesostructured nanoparticles and are involved in inactivating enveloping and non-enveloping viruses. Graphene in face masks can also sterilize SARS-CoV-2 and allow them to be reused. This coating is also suitable for use on surface in public places.

The unpredictable and unknown nature of COVID-19 and the similarity of the specific properties this disease and the physicochemical properties of nanosystems will lead to the discussion of solutions based on new technologies.

Prof. Dr. Takashi Onodera
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Calcium oxides
  • Calcium bicarbonates
  • disinfection
  • Graphene
  • heated scallop-shell powder
  • photocatalysis
  • SARS-CoV-2

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (8 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Editorial

Jump to: Research, Review

3 pages, 182 KiB  
Editorial
New Advances in Viral and Microorganism Disinfectants
by Takashi Onodera and Rikio Kirisawa
Microorganisms 2023, 11(10), 2530; https://doi.org/10.3390/microorganisms11102530 - 10 Oct 2023
Viewed by 1250
Abstract
Nanomaterials are used to develop simpler, cheaper, and faster methods for disease diagnosis [...] Full article
(This article belongs to the Special Issue The New Advance on Disinfectant of Virus and Microorganisms)

Research

Jump to: Editorial, Review

13 pages, 2842 KiB  
Article
Antibacterial and Photocatalytic Activities of LDH-Based Sorbents of Different Compositions
by Anna Maria Cardinale, Stefano Alberti, Andrea Pietro Reverberi, Michelina Catauro, Nicolò Ghibaudo and Marco Fortunato
Microorganisms 2023, 11(4), 1045; https://doi.org/10.3390/microorganisms11041045 - 16 Apr 2023
Cited by 5 | Viewed by 1876
Abstract
Layered double hydroxides (LDHs) play a fundamental role in the processes for the abatement of pollutants in water, with reference to heavy metal decontamination. The research on the topic is multiobjective target oriented, aiming at combining environmental remediation with the possibility of reusing [...] Read more.
Layered double hydroxides (LDHs) play a fundamental role in the processes for the abatement of pollutants in water, with reference to heavy metal decontamination. The research on the topic is multiobjective target oriented, aiming at combining environmental remediation with the possibility of reusing a sorbent as many times as possible, turning it into a renewable resource. In this study, the antibacterial and catalytic properties of a ZnAl-SO4 LDH and its resulting product after being subjected to a Cr(VI) remediation process are compared. Both solid substrates have also been tested after undergoing a thermal annealing process. The sorbent (previously described and tested for remediation) has been investigated for its antibacterial activity in view of further surgery and drug delivery applications. Finally, its photocatalytic properties have been experimentally tested in the degradation of a model pollutant, i.e., Methyl Orange (MO), under solar-simulated light. Identifying the best recycling strategy for these materials requires an accurate knowledge of their physicochemical properties. The results show that both the antimicrobial activity and the photocatalytic performance may considerably improve after thermal annealing. Full article
(This article belongs to the Special Issue The New Advance on Disinfectant of Virus and Microorganisms)
►▼ Show Figures

Figure 1

13 pages, 7655 KiB  
Article
Antibacterial Enhancement of High-Efficiency Particulate Air Filters Modified with Graphene-Silver Hybrid Material
by Alexandra Ciorîță, Maria Suciu, Maria Coroş, Codruța Varodi, Florina Pogăcean, Lidia Măgeruşan, Valentin Mirel, Raluca-Ioana Ștefan-van Staden and Stela Pruneanu
Microorganisms 2023, 11(3), 745; https://doi.org/10.3390/microorganisms11030745 - 14 Mar 2023
Cited by 7 | Viewed by 1870
Abstract
Bacterial infections are a major concern as antibiotic resistance poses a great threat, therefore leading to a race against time into finding new drugs or improving the existing resources. Nanomaterials with high surface area and bactericidal properties are the most promising ones that [...] Read more.
Bacterial infections are a major concern as antibiotic resistance poses a great threat, therefore leading to a race against time into finding new drugs or improving the existing resources. Nanomaterials with high surface area and bactericidal properties are the most promising ones that help combating microbial infections. In our case, graphene decorated with silver nanoparticles Gr-Ag (5 wt% Ag) exhibited inhibitory capacity against S. aureus and E. coli. The newly formed hybrid material was next incubated with high-efficiency particulate air (HEPA) filter, to obtain one with bactericidal properties. The modified filter had greater inhibitory action against the tested strains, compared to the control, and the effect was better against the Gram-negative model. Even if the bacteria remained attached to the filters, their colony forming unit capacity was affected by the Gr-Ag (5 wt% Ag) hybrid material, when they were subsequently re-cultured on fresh agar media. Therefore, the HEPA filter modified with Gr-Ag (5 wt% Ag) has high antibacterial properties that may substantially improve the existing technology. Full article
(This article belongs to the Special Issue The New Advance on Disinfectant of Virus and Microorganisms)
►▼ Show Figures

Figure 1

10 pages, 793 KiB  
Communication
Antiviral Effect of Ephedrine Alkaloids-Free Ephedra Herb Extract against SARS-CoV-2 In Vitro
by Masashi Uema, Masashi Hyuga, Kenzo Yonemitsu, Sumiko Hyuga, Yoshiaki Amakura, Nahoko Uchiyama, Kazushige Mizoguchi, Hiroshi Odaguchi and Yukihiro Goda
Microorganisms 2023, 11(2), 534; https://doi.org/10.3390/microorganisms11020534 - 20 Feb 2023
Cited by 6 | Viewed by 2737
Abstract
We report for the first time that ephedrine alkaloids-free Ephedra Herb extract (EFE) directly inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and that the addition of EFE to the culture medium before viral infection reduces virus titers [...] Read more.
We report for the first time that ephedrine alkaloids-free Ephedra Herb extract (EFE) directly inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and that the addition of EFE to the culture medium before viral infection reduces virus titers in the culture supernatant of SARS-CoV-2, including those of variant strains, by more than 99%, 24 h after infection. The addition of Ephedra Herb macromolecule condensed-tannin, which is the main active ingredient responsible for the anticancer, pain suppression, and anti-influenza effects of EFE, similarly suppressed virus production in the culture supernatant by 99% before infection and by more than 90% after infection. Since EFE does not have the side effects caused by ephedrine alkaloids, such as hypertension, palpitations, and insomnia, our results showed the potential of EFE as a safe therapeutic agent against coronavirus disease 2019. Full article
(This article belongs to the Special Issue The New Advance on Disinfectant of Virus and Microorganisms)
►▼ Show Figures

Figure 1

9 pages, 966 KiB  
Communication
Epigallocatechin Gallate Stabilized by Cyclodextrin Inactivates Influenza Virus and Human Coronavirus 229E
by Ryosuke Matsuura, Arisa Kawamura, Yasunobu Matsumoto, Yoshiki Iida, Masanori Kanayama, Masahiko Kurokawa and Yoko Aida
Microorganisms 2022, 10(9), 1796; https://doi.org/10.3390/microorganisms10091796 - 6 Sep 2022
Cited by 8 | Viewed by 1811
Abstract
Natural products are attractive antiviral agents because they are environment-friendly and mostly harmless. Epigallocatechin gallate (EGCg), a type of catechin, is a well-known natural antiviral agent that can inhibit various viruses. However, EGCg easily oxidizes and loses its physiological activity. Although this problem [...] Read more.
Natural products are attractive antiviral agents because they are environment-friendly and mostly harmless. Epigallocatechin gallate (EGCg), a type of catechin, is a well-known natural antiviral agent that can inhibit various viruses. However, EGCg easily oxidizes and loses its physiological activity. Although this problem can be overcome by combining EGCg with cyclodextrin (CD-EGCg), which makes it stable in water at high concentrations, the antiviral effect of this compound remains unclear. Here, we show that in Madin–Darby canine kidney (MDCK) and MRC-5 cells, CD-EGCg is cytotoxic for 50% of cells at 85.61 and 65.34 ppm, respectively. Furthermore, CD-EGCg mainly shows its antiviral effect during the adsorption step for all four influenza virus strains (median effect concentration (EC50) was 0.93 to 2.78 ppm). Its antiviral effect post-adsorption is less intense, and no inhibitory effect is observed on influenza viruses pre-adsorption. Moreover, human coronavirus 229E (HCoV-229E) was inhibited at the adsorption step in short contact (EC50 = 2.5 ppm) and long contact conditions (EC50 = 0.5 ppm) by mixing CD-EGCg with HCoV-229E. These results suggest that CD-EGCg effectively inhibits various viruses that require an adsorption step, and is an effective tool for preventing infection. Full article
(This article belongs to the Special Issue The New Advance on Disinfectant of Virus and Microorganisms)
►▼ Show Figures

Figure 1

10 pages, 1173 KiB  
Article
Evaluation of Virucidal Quantitative Carrier Test towards Bovine Viruses for Surface Disinfectants While Simulating Practical Usage on Livestock Farms
by Md. Amirul Hasan, Yu Miyaoka, Md. Humayun Kabir, Chisaki Kadota, Hakimullah Hakim, Dany Shoham, Harumi Murakami and Kazuaki Takehara
Microorganisms 2022, 10(7), 1320; https://doi.org/10.3390/microorganisms10071320 - 30 Jun 2022
Cited by 3 | Viewed by 2314
Abstract
Livestock farming is affected by the occurrence of infectious diseases, but outbreaks can be prevented by effective cleaning and disinfection along with proper farm management. In the present study, bovine coronavirus (BCoV) and bovine rotavirus A (RVA) were inactivated using food additive-grade calcium [...] Read more.
Livestock farming is affected by the occurrence of infectious diseases, but outbreaks can be prevented by effective cleaning and disinfection along with proper farm management. In the present study, bovine coronavirus (BCoV) and bovine rotavirus A (RVA) were inactivated using food additive-grade calcium hydroxide (FdCa(OH)2) solution, quaternary ammonium compound (QAC) and their mixture through suspension tests as the primary screening, and afterward via carrier tests using dropping or dipping techniques as the secondary screenings. Viruses in the aqueous phase can be easily inactivated in the suspension tests, but once attached to the materials, they can become resistant to disinfectants, and require longer times to be inactivated. This highlights the importance of thorough cleaning with detergent before disinfection, and keeping elevated contact durations of proper disinfectants to reduce viral contamination and decrease infectious diseases incidence in farms. It was also reaffirmed that the suspension and carrier tests are necessary to evaluate disinfectants and thus determine their actual use. Particularly, the mixture of QAC and FdCa(OH)2 was found to exhibit synergistic and broad-spectrum effects compared to their use alone, and is now recommended for use on livestock farms. Full article
(This article belongs to the Special Issue The New Advance on Disinfectant of Virus and Microorganisms)
►▼ Show Figures

Figure 1

15 pages, 293 KiB  
Article
Universal Virucidal Activity of Calcium Bicarbonate Mesoscopic Crystals That Provides an Effective and Biosafe Disinfectant
by Rikio Kirisawa, Rika Kato, Koichi Furusaki and Takashi Onodera
Microorganisms 2022, 10(2), 262; https://doi.org/10.3390/microorganisms10020262 - 24 Jan 2022
Cited by 9 | Viewed by 3772
Abstract
We investigated the virucidal effects in solution of a new type of disinfectant, calcium bicarbonate mesoscopic crystals, designated CAC-717, against various types of virus. CAC-717 in solution is alkaline (pH 12.4) and has a self-electromotive force that generates pulsed electrical fields. Upon application [...] Read more.
We investigated the virucidal effects in solution of a new type of disinfectant, calcium bicarbonate mesoscopic crystals, designated CAC-717, against various types of virus. CAC-717 in solution is alkaline (pH 12.4) and has a self-electromotive force that generates pulsed electrical fields. Upon application to human skin, the pH of the solution becomes 8.4. CAC-717 contains no harmful chemicals and is thus non-irritating and harmless to humans and animals. Its virucidal effects were tested against six types of animal virus: enveloped double-strand (ds)-DNA viruses, non-enveloped ds-DNA viruses, non-enveloped single strand (ss)-DNA viruses, enveloped ss-RNA viruses, non-enveloped ss-RNA viruses, and non-enveloped ds-RNA viruses. The treatment resulted in a reduction in viral titer of at least 3.00 log10 to 6.38 log10. Fetal bovine serum was added as a representative organic substance. When its concentration was ≥20%, the virucidal effect of CAC-717 was reduced. Real-time PCR revealed that CAC-717 did not reduce the quantity of genomic DNA of most of the DNA viruses, but it greatly reduced that of the genomic RNA of most of the RNA viruses. CAC-717 may therefore be a useful biosafe disinfectant for use against a broad range of viruses. Full article
(This article belongs to the Special Issue The New Advance on Disinfectant of Virus and Microorganisms)

Review

Jump to: Editorial, Research

22 pages, 3206 KiB  
Review
An Overview on Exploitation of Graphene-Based Membranes: From Water Treatment to Medical Industry, Including Recent Fighting against COVID-19
by Cristina Lavorato and Enrica Fontananova
Microorganisms 2023, 11(2), 310; https://doi.org/10.3390/microorganisms11020310 - 25 Jan 2023
Cited by 5 | Viewed by 2518
Abstract
Graphene and its derivatives have lately been the subject of increased attention for different environmental applications of membrane technology such as water treatment and air filtration, exploiting their antimicrobial and antiviral activity. They are interesting candidates as membrane materials for their outstanding mechanical [...] Read more.
Graphene and its derivatives have lately been the subject of increased attention for different environmental applications of membrane technology such as water treatment and air filtration, exploiting their antimicrobial and antiviral activity. They are interesting candidates as membrane materials for their outstanding mechanical and chemical stability and for their thin two-dimensional (2D) nanostructure with potential pore engineering for advanced separation. All these applications have evolved and diversified from discovery to today, and now graphene and graphene derivatives also offer fascinating opportunities for the fight against infective diseases such as COVID-19 thanks to their antimicrobial and antiviral properties. This paper presents an overview of graphene-based 2D materials, their preparation and use as membrane material for applications in water treatment and in respiratory protection devices. Full article
(This article belongs to the Special Issue The New Advance on Disinfectant of Virus and Microorganisms)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-8
Back to TopTop