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Molecules
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Discovery of Functional Foods: Bioactive, Antioxidant, Anti-inflammatory
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Discovery of Functional Foods: Bioactive, Antioxidant, Anti-inflammatory

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Food Chemistry".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 3523

Special Issue Editors

Dr. Agata Antoniewska-Krzeska

E-Mail Website
Guest Editor
Institute of Human Nutrition Sciences, Faculty of Human Nutrition, Warsaw University of Life Sciences, Nowoursynowska st.159c, 02-776 Warsaw, Poland
Interests: food chemistry; chromatography; volatile compounds; lipid oxidation; antioxidants; bioactive compounds; functional foods; plant ingredients
Dr. Patricia Cazón

E-Mail Website
Guest Editor
Department of Analytical Chemistry, Faculty of Veterinary, University of Santiago de Compostela, 27002 Lugo, Spain
Interests: food science and technology; biopolymers; food packaging film; chitosan; bacterial cellulose; essential oils; plant extracts; antioxidant properties

Special Issue Information

Dear Colleagues,

Recently, the global interest in functional foods and nutraceuticals gained much attention due to an increased consumer demand for healthy nutritious food with additional health-promoting effects. Valuable bioactive compounds, including polyphenols, flavonoids, carotenoids, vitamins, phytosterols and n-3 fatty acids, are defined as key food components that reduce the risks of certain chronic diseases. Bioactive compounds are naturally found in various foodstuffs, mainly fruits, vegetables, cereals, olive oil, tea, coffee, and wine. Thus, the development of new functional foods is becoming a high priority for many scientists and food technologists.

We kindly invite authors to submit high-quality original research articles and review manuscripts that address current advances in the development of functional foods with antioxidant and/or anti-inflammatory properties. Contributions to this Special Issue should consist of studies related to the potential application of plant-based ingredients, natural extracts, essential oils, and by-products rich in bioactive compounds in different food matrices. We also welcome research on the bioactive compounds; antioxidant potential; and physicochemical, sensory, and functional properties of novel foods. In addition, studies on the composition (volatiles, fatty acids, phenolics, etc.) of functional foods, improvements in analytical methods, and recent advances in the isolation or identification of bioactive compounds in foodstuffs are addressed.

Dr. Agata Antoniewska-Krzeska
Dr. Patricia Cazón
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional foods and nutraceuticals
  • plant-based food ingredients
  • composition of functional foods
  • food enrichment
  • by-products
  • active packaging film application
  • natural extracts
  • essential oils
  • bioactive compounds
  • phenolic-rich foods
  • antioxidant activity
  • volatile compounds
  • chromatography
  • sensory properties
  • storage stability
  • anti-inflammatory agents
  • health-promoting effects

Published Papers (1 paper)

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Review

11 pages, 559 KiB  
Review
Impact of Pomegranate Juice on the Pharmacokinetics of CYP3A4- and CYP2C9-Mediated Drugs Metabolism: A Preclinical and Clinical Review
by Kenza Mansoor, Razan Bardees, Bayan Alkhawaja, Eyad Mallah, Luay AbuQatouseh, Mathias Schmidt and Khalid Matalka
Molecules 2023, 28(5), 2117; https://doi.org/10.3390/molecules28052117 - 24 Feb 2023
Cited by 5 | Viewed by 3155
Abstract
The Punica granatum L. (pomegranate) fruit juice contains large amounts of polyphenols, mainly tannins such as ellagitannin, punicalagin, and punicalin, and flavonoids such as anthocyanins, flavan-3-ols, and flavonols. These constituents have high antioxidant, anti-inflammatory, anti-diabetic, anti-obesity, and anticancer activities. Because of these activities, [...] Read more.
The Punica granatum L. (pomegranate) fruit juice contains large amounts of polyphenols, mainly tannins such as ellagitannin, punicalagin, and punicalin, and flavonoids such as anthocyanins, flavan-3-ols, and flavonols. These constituents have high antioxidant, anti-inflammatory, anti-diabetic, anti-obesity, and anticancer activities. Because of these activities, many patients may consume pomegranate juice (PJ) with or without their doctor’s knowledge. This may raise any significant medication errors or benefits because of food-drug interactions that modulate the drug’s pharmacokinetics or pharmacodynamics. It has been shown that some drugs exhibited no interaction with pomegranate, such as theophylline. On the other hand, observational studies reported that PJ prolonged the pharmacodynamics of warfarin and sildenafil. Furthermore, since it has been shown that pomegranate constituents inhibit cytochrome P450 (CYP450) activities such as CYP3A4 and CYP2C9, PJ may affect intestinal and liver metabolism of CYP3A4 and CYP2C9-mediated drugs. This review summarizes the preclinical and clinical studies that investigated the impact of oral PJ administration on the pharmacokinetics of drugs that are metabolized by CYP3A4 and CYP2C9. Thus, it will serve as a future road map for researchers and policymakers in the fields of drug-herb, drug-food and drug-beverage interactions. Preclinical studies revealed that prolonged administration of PJ increased the absorption, and therefore the bioavailability, of buspirone, nitrendipine, metronidazole, saquinavir, and sildenafil via reducing the intestinal CYP3A4 and CYP2C9. On the other hand, clinical studies are limited to a single dose of PJ administration that needs to be protocoled with prolonged administration to observe a significant interaction. Full article
(This article belongs to the Special Issue Discovery of Functional Foods: Bioactive, Antioxidant, Anti-inflammatory)
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