Crystal Structure and Function of Biological Macromolecules
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Molecular Structure".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 4728
Special Issue Editor
Special Issue Information
Dear Colleagues,
All biological functions depend on biomacromolecules such as proteins, nucleic acid, carbohydrates, lipids, and complexes thereof. Additionally, proteins compose structural and motor elements in the microorganism, and they serve as catalysts for virtually every biochemical reaction that occurs in living things. A study of the three-dimensional structure of proteins revealed their molecular function, as well as their relationship with normal biological functions and abnormal physiological phenomena, thus revealing the life phenomenon essential to the discipline. This is the cornerstone of biology.
In recent years, research on the gut microbiota has been very active. Additionally, the gut microbiota plays a crucial role in the maintenance of human colon health and, when altered, contributes to emerging diseases, such as ulcerative colitis and type II diabetes. However, the pathogenic mechanism of gut microbiota remains unknown, and the studies on pathogenic proteins are few. Therefore, in combination with X-ray diffraction technique, etc., the molecular function and mechanism of pathogenic proteins are revealed at the atomic and molecular levels. Growing knowledge of these pathogenic proteins has already contributed significantly to a molecular understanding of disease. In addition, based on the crystal structure of these proteins, the inhibitors can be developed. These studies show promise as a treatment for disease and may lead to the development of a new drug. In a word, these studies have laid the foundation for us to expound their molecular function and mechanism and new drug development.
The focus of this Special Issue includes, but is not limited to, the study of crystal structure and the function of biological macromolecules. We are pleased to invite experts in the field to publish their latest developments and concepts in this Special Issue in the form of short communications, full-length papers, and reviews. We hope that this acquired knowledge will provide further insight and a solid pool of data for future developments in crystal structure and the function of biological macromolecules.
Dr. Yongbin Xu
Guest Editor
Manuscript Submission Information
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Keywords
- structural biology
- biomacromolecule
- crystal structure
- molecular function and mechanism
- gut microbiota
- drug development
