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Functional Organic Molecules: Synthesis and Applications
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Functional Organic Molecules: Synthesis and Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 6891

Special Issue Editor

Prof. Dr. Kamajit Singh

E-Mail Website
Guest Editor
Department of Chemistry, Centre for Advanced Study, Guru Nanak Dev University, Amritsar 143005, India
Interests: synthetic organic chemistry; medicinal chemistry; materials chemistry

Special Issue Information

Dear Colleagues,

We are pleased to announce a Special Issue entitled “Functional Organic Molecules: Synthesis and Applications” and welcome manuscripts (original research papers, short communications, or focused reviews) on the topics covered under this and related areas. The synthesis of novel organic compounds using design strategies to incorporate structural features for specific applications has enjoyed unprecedented research activity. Consequently, organic compounds are finding applications in a variety of areas such as (but not limited to) medicinal chemistry, organocatalysis, asymmetric synthesis, colorants (dyes and organic pigments), agrochemicals, functional organic materials such as organic semiconductors, chemosensors for detection of different analytes, organic light emitting diodes, organic photovoltaics, electrochromism, optoelectronics, medical diagnostics, etc.

Prof. Dr. Kamajit Singh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organic compounds
  • organic synthetic methodology
  • organocatalysis
  • asymmetric synthesis
  • drug design and synthesis
  • medicinal chemistry
  • functional organic materials
  • colourants

Published Papers (3 papers)

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Research

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11 pages, 1996 KiB  
Article
Nerve Targeting via Myelin Protein Zero and the Impact of Dimerization on Binding Affinity
by Nataliia Berehova, Tessa Buckle, Maarten P. van Meerbeek, Anton Bunschoten, Aldrik H. Velders and Fijs W. B. van Leeuwen
Molecules 2022, 27(24), 9015; https://doi.org/10.3390/molecules27249015 - 17 Dec 2022
Cited by 1 | Viewed by 2465
Abstract
Background: Surgically induced nerve damage is a common but debilitating side effect. By developing tracers that specifically target the most abundant protein in peripheral myelin, namely myelin protein zero (P0), we intend to support fluorescence-guided nerve-sparing surgery. To that end, we aimed to [...] Read more.
Background: Surgically induced nerve damage is a common but debilitating side effect. By developing tracers that specifically target the most abundant protein in peripheral myelin, namely myelin protein zero (P0), we intend to support fluorescence-guided nerve-sparing surgery. To that end, we aimed to develop a dimeric tracer that shows a superior affinity for P0. Methods: Following truncation of homotypic P0 protein-based peptide sequences and fluorescence labeling, the lead compound Cy5-P0101–125 was selected. Using a bifunctional fluorescent dye, the dimeric Cy5-(P0101–125)2 was created. Assessment of the performance of the mono- and bi-labeled compounds was based on (photo)physical evaluation. This was followed by in vitro assessment in P0 expressing Schwannoma cell cultures by means of fluorescence confocal imaging (specificity, location of binding) and flow cytometry (binding affinity; KD). Results: Dimerization resulted in a 1.5-fold increase in affinity compared to the mono-labeled counterpart (70.3 +/− 10.0 nM vs. 104.9 +/− 16.7 nM; p = 0.003) which resulted in a 4-fold increase in staining efficiency in P0 expressing Schwannoma cells. Presence of two targeting vectors also improves a pharmacokinetics of labeled compounds by lowering serum binding and optical stability by preventing dye stacking. Conclusions: Dimerization of the nerve-targeting peptide P0101–125 proves a valid strategy to improve P0 targeting. Full article
(This article belongs to the Special Issue Functional Organic Molecules: Synthesis and Applications)
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16 pages, 4957 KiB  
Article
AIE+ESIPT Active Hydroxybenzothiazole for Intracellular Detection of Cu2+: Anticancer and Anticounterfeiting Applications
by Rajdeep Kaur, Rasdeep Kour, Satwinder Singh Marok, Satwinderjeet Kaur and Prabhpreet Singh
Molecules 2022, 27(22), 7678; https://doi.org/10.3390/molecules27227678 - 8 Nov 2022
Cited by 8 | Viewed by 1612
Abstract
Here, in the present work, a new hydroxybenzothiazole derivative (HBT 2) with AIE+ESIPT features was synthesized by Suzuki–Miyora coupling of HBT 1 with 4-formylphenylboronic acid. The AIE and ESIPT features were confirmed by optical, microscopic (AFM) and dynamic light scattering (DLS) [...] Read more.
Here, in the present work, a new hydroxybenzothiazole derivative (HBT 2) with AIE+ESIPT features was synthesized by Suzuki–Miyora coupling of HBT 1 with 4-formylphenylboronic acid. The AIE and ESIPT features were confirmed by optical, microscopic (AFM) and dynamic light scattering (DLS) techniques. The yellow fluorescent aggregates of HBT 2 can specifically detect Cu2+/Cu+ ions with limits of detection as low as 250 nM and 69 nM. The Job’s plot revealed the formation of a 1:1 complex. The Cu2+ complexation was further confirmed by optical, NMR, AFM and DLS techniques. HBT 2 was also used for the detection of Cu2+ ions in real water samples collected from different regions of Punjab. HBT 2 was successfully used for the bio-imaging of Cu2+ ions in live A549 and its anticancer activity was checked on different cancer cell lines, such as MG63, and HeLa, and normal cell lines such as L929. We successfully utilized HBT 2 to develop security labels for anticounterfeiting applications. Full article
(This article belongs to the Special Issue Functional Organic Molecules: Synthesis and Applications)
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Review

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24 pages, 8276 KiB  
Review
Tyrosinase Inhibitors: A Perspective
by Mason A. Baber, Cole M. Crist, Noah L. Devolve and James D. Patrone
Molecules 2023, 28(15), 5762; https://doi.org/10.3390/molecules28155762 - 30 Jul 2023
Cited by 5 | Viewed by 2451
Abstract
Due to its integral role in the biosynthesis of melanin in all kingdoms of life, tyrosinase has become an extremely important target for inhibition in several sectors of research including agricultural and cosmetic research. Inhibitors of tyrosinase have made it to the market [...] Read more.
Due to its integral role in the biosynthesis of melanin in all kingdoms of life, tyrosinase has become an extremely important target for inhibition in several sectors of research including agricultural and cosmetic research. Inhibitors of tyrosinase have made it to the market in the cosmetics industry, but their use has been limited due to conflicting efficacy and potential toxicity, which has led to several small molecules being removed from the market. Undaunted, researchers have continued to pursue tyrosinase inhibitors with varying degrees of success. These pursuits have built an impressive and rich library of research. This review is intended to provide a perspective of the past twenty years (2003–2023) of research on tyrosinase inhibitors by highlighting exemplar molecules and developments. Full article
(This article belongs to the Special Issue Functional Organic Molecules: Synthesis and Applications)
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