Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.4
4.2
Journals
Molecules
Special Issues
Novel Antimicrobial Bioactive Molecules for Sustainable Development and Health Care
molecules-logo
Submit to Molecules Review for Molecules Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Novel Antimicrobial Bioactive Molecules for Sustainable Development and Health Care

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Cross-Field Chemistry".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 3619

Special Issue Editor

Prof. Dr. Shoorvir Vir Singh

E-Mail Website
Guest Editor
Department of Biotechnology, GLA University, Mathura, India
Interests: mycobacterial genomics; proteomics; vaccinology; diagnostics

Special Issue Information

Dear Colleagues,

Sustainable development promotes the efficient sustainable practices and solutions needed to protect the environment and natural resources for future generations. Developing advanced plant-derived antimicrobial molecules/metabolites requires evaluating and understanding the relationships between structure, properties, and behavior before, during, and after commercialization. Since few new anti-Gram-positive or -negative and anti-mycobacterial drugs have entered clinical trials, there is a need to develop new molecules/ metabolites and methods to improve their delivery and diagnostics to lead to excellent safety and overcome the problem of resistance to chemically synthesized drugs and the reluctance to recover the activity of existing drugs. This Special Issue seeks original research papers and abstracts (reviews) that are making significant strides in this field, and invites researchers from a variety of disciplines (medicinal/nanochemistry, biotechnology, biochemistry, and pharmaceutics). Our goal is to cover novel antimicrobial bioactive molecules as well as botanicals, covering both broad-spectrum and single-target antibiotics for both human and animal use.

Prof. Dr. Shoorvir Vir Singh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anti-microbial agents
  • plant-derived molecules
  • bioactive vaccine candidates
  • diagnostics

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

16 pages, 7286 KiB  
Article
Antibacterial Effect of Shrimp By-Products Hydrolysate on Specific Spoilage Organisms of Squid
by Luo Gu, Qiuyu Zhu, Xiaoyu Zou and Ru Song
Molecules 2023, 28(10), 4105; https://doi.org/10.3390/molecules28104105 - 15 May 2023
Cited by 3 | Viewed by 1579
Abstract
In order to further develop and utilize shrimp processing by-products, in this study, a novel antibacterial hydrolysate of shrimp by-products by pepsin hydrolysis (SPH) was prepared. The antibacterial effect of SPH on specific spoilage organisms of squid after end storage at room temperature [...] Read more.
In order to further develop and utilize shrimp processing by-products, in this study, a novel antibacterial hydrolysate of shrimp by-products by pepsin hydrolysis (SPH) was prepared. The antibacterial effect of SPH on specific spoilage organisms of squid after end storage at room temperature (SE–SSOs) was investigated. SPH showed an antibacterial effect on the growth of SE–SSOs, with (23.4 ± 0.2) mm of inhibition zone diameter. The cell permeability of SE–SSOs was enhanced after SPH treatment for 12 h. Some bacteria were twisted and shrunk, while pits and pores formed and intracellular contents leaked under scanning electron microscopy observation. The flora diversity of SE–SSOs treated with SPH was determined by a 16S rDNA sequencing technique. Results showed that SE–SSOs were mainly composed of the phyla of Firmicutes and Proteobacteria, among which Paraclostridium (47.29%) and Enterobacter (38.35%) were dominant genera. SPH treatment resulted in a significant reduction in the relative abundance of the genus Paraclostridium and increased the abundance of Enterococcus. Linear discriminant analysis (LDA) of LEfSe conveyed that SPH treatment had a significant impact on altering the bacterial structure of SE–SSOs. The 16S PICRUSt of Cluster of Orthologous Group (COG) annotation revealed that SPH treatment for 12 h could significantly increase the function of transcription level [K], while SPH treatment for 24 h could downregulate post-translational modifications, protein turnover, and chaperone metabolism functions [O]. In conclusion, SPH has a proper antibacterial effect on SE–SSOs and can change the flora structure of SE–SSOs. These findings will provide a technical basis for the development of inhibitors of squid SSOs. Full article
(This article belongs to the Special Issue Novel Antimicrobial Bioactive Molecules for Sustainable Development and Health Care)
►▼ Show Figures

Figure 1

Review

Jump to: Research

17 pages, 2074 KiB  
Review
Bioprospective Role of Ocimum sanctum and Solanum xanthocarpum against Emerging Pathogen: Mycobacterium avium Subspecies paratuberculosis: A Review
by Manthena Nava Bharath, Saurabh Gupta, Garima Vashistha, Sayeed Ahmad and Shoor Vir Singh
Molecules 2023, 28(8), 3490; https://doi.org/10.3390/molecules28083490 - 15 Apr 2023
Cited by 2 | Viewed by 1755
Abstract
Mycobacterium avium subspecies paratuberculosis (MAP) is a chronic, contagious, and typically life-threatening enteric disease of ruminants caused by a bacterium of the genus Mycobacterium, but it can also affect non-ruminant animals. MAP transmission occurs through the fecal–oral pathway in neonates and young animals. [...] Read more.
Mycobacterium avium subspecies paratuberculosis (MAP) is a chronic, contagious, and typically life-threatening enteric disease of ruminants caused by a bacterium of the genus Mycobacterium, but it can also affect non-ruminant animals. MAP transmission occurs through the fecal–oral pathway in neonates and young animals. After infection, animals generate IL-4, IL-5, and IL-10, resulting in a Th2 response. Early detection of the disease is necessary to avoid its spread. Many detection methods, viz., staining, culture, and molecular methods, are available, and numerous vaccines and anti-tuberculosis drugs are used to control the disease. However, the prolonged use of anti-tuberculosis drugs leads to the development of resistance. Whereas vaccines hamper the differentiation between infected and vaccinated animals in an endemic herd. This leads to the identification of plant-based bioactive compounds to treat the disease. Bioactive compounds of Ocimum sanctum and Solanum xanthocarpum have been evaluated for their anti-MAP activity. Based on the MIC50 values, Ursolic acid (12 µg/mL) and Solasodine (60 µg/mL) were found to be suitable for anti-MAP activity. Full article
(This article belongs to the Special Issue Novel Antimicrobial Bioactive Molecules for Sustainable Development and Health Care)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop