Chemical and Synthetic Biology Approaches in Cancer Immunotherapy

Dear Colleagues,

Cancer immunotherapy (immuno-oncology) is a promising and effective treatment strategy for different types of cancer in clinic. It is a broad concept that includes therapies based on antibodies, chimeric antigen receptor (CAR) T cells, natural killer (NK) cells, bacteria, viruses, etc. Thus, interdisciplinary methods, such as chemical and synthetic biology approaches, facilitate the development of immuno-oncology. Recent chemical and synthetic biology advances have provided great opportunities for basic and translational studies of novel cancer immunotherapies, including the development of proteolysis targeting chimeric (PROTAC) technology, molecular glues, checkpoint inhibitors, antibody-drug conjugates (ADCs), tumor vaccines, chemical probes for mechanistic research, and the engineering of gene circuits in therapeutic cells.

This Special Issue aims to provide a broad survey of the most recent advances in the methodology development and applications of chemical and synthetic biology approaches in cancer immunotherapy. Original research articles or reviews focused on basic or translational studies that discuss new chemical probes, drug leads, cancer vaccines, methodologies, and synthetic biology systems for immuno-oncology are welcome.

Dr. Qingfei Zheng
Dr. Qinglan Wang
Guest Editors

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