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Molecules
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Natural Products as Anti-inflammatory and Immunomodulatory Drugs
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Natural Products as Anti-inflammatory and Immunomodulatory Drugs

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 16713

Special Issue Editors

Prof. Dr. Patrick Dutartre

E-Mail Website
Guest Editor
Bioperoxyl Lab Burgundy University, France
Interests: pharmacology of natural plant and animal extracts; modulation of pathways of inflammasomes with natural products acting as anti-inflammatory and/or immunomodulatory agents
Prof. Dr. Marie Aleth Lacaille Dubois

E-Mail Website
Guest Editor
University of Bourgogne Franche-Comté, Dijon, France
Interests: natural products; isolation, structure elucidation; biological assessment

Special Issue Information

Dear Colleagues,

Natural plant extracts remain a source of bioactive compounds demonstrating new anti-inflammatory and / or immunomodulatory activities even after extensive studies. Due to the very low oral biodisponibility observed in rather all actives mixture or purified compounds the final use as orally active pharmacologic agents is exception.

In this special issue we will publish laboratory demonstration and reviews concerning plant extracts acting directly or indirectly on immune response in organs in contact with the external domain. Potential topics include, but are not limited to, purification and structural elucidation, activity on skin homeostasis, eye immunity, mouth inflammation, gastro-intestinal homeostasis, pre and probiotics activities and immune answer of vagina.

Prof. Patrick Dutartre
Prof. Marie Aleth Lacaille Dubois
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Inflammasomes
  • Natural plant extracts
  • Inflammatory agents
  • Immunomodulatory agents
  • Gastro-intestinal homeostasis
  • Eye immunity
  • Mouth immunity
  • Vaginal immunity
  • Prebiotics
  • Probiotics

Published Papers (3 papers)

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Research

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9 pages, 1641 KiB  
Article
New 12,23-Epoxydammarane Type Saponins Obtained from Panax notoginseng Leaves and Their Anti-Inflammatory Activity
by Jingya Ruan, Ying Zhang, Wei Zhao, Fan Sun, Lifeng Han, Haiyang Yu, Lijie Wu, Yi Zhang and Tao Wang
Molecules 2020, 25(17), 3784; https://doi.org/10.3390/molecules25173784 - 20 Aug 2020
Cited by 9 | Viewed by 2222
Abstract
Two new 12,23-epoxydammarane-type saponins, notoginsenosides NL-I (1) and NL-J (2), were isolated and identified from Panax notoginseng leaves through the combination of various chromatographies and extensive spectroscopic methods, as well as chemical reactions. Among them, notoginsenoside NL-J (2 [...] Read more.
Two new 12,23-epoxydammarane-type saponins, notoginsenosides NL-I (1) and NL-J (2), were isolated and identified from Panax notoginseng leaves through the combination of various chromatographies and extensive spectroscopic methods, as well as chemical reactions. Among them, notoginsenoside NL-J (2) had a new skeleton. Furthermore, the lipopolysaccharide (LPS)-induced RAW 264.7 macrophage model was used to identify the in vitro anti-inflammatory activity and mechanisms of compounds 1 and 2. Both of them exerted strong inhibition on nitric oxide (NO) productions in a concentration-dependent manner at 1, 10, and 25 μM. Moreover, these two compounds significantly decreased the secretion of tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), cyclooxygenase-2 (COX-2), nuclear factor kappa-B (NF-κB/p65), and nitric-oxide synthase (iNOS) in LPS-activated RAW 264.7 cells. Full article
(This article belongs to the Special Issue Natural Products as Anti-inflammatory and Immunomodulatory Drugs)
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16 pages, 6855 KiB  
Article
Banhahubak-Tang Tablet, a Standardized Medicine Attenuates Allergic Asthma via Inhibition of Janus Kinase 1 (JAK1)/ Signal Transducer and Activator of Transcription 6 (STAT6) Signal Pathway
by Yeon Kyung Nam, Seong Chul Jin, Mi Hye Kim, La Yoon Choi, Yong-Bok Lee and Woong Mo Yang
Molecules 2020, 25(9), 2206; https://doi.org/10.3390/molecules25092206 - 8 May 2020
Cited by 9 | Viewed by 4596
Abstract
Exposure to particulate matter (PM) has been known to be one of the risk factors to cause allergic asthma, leading to development of respiratory disease. Banhahubak-tang tablet (BHT), a standardized Korean Medicine, is prescribed for neurasthenia, laryngopharyngitis and asthma. In this study, [...] Read more.
Exposure to particulate matter (PM) has been known to be one of the risk factors to cause allergic asthma, leading to development of respiratory disease. Banhahubak-tang tablet (BHT), a standardized Korean Medicine, is prescribed for neurasthenia, laryngopharyngitis and asthma. In this study, we investigated therapeutic effects of BHT on airway inflammation in ovalbumin (OVA) and PM smaller than 10 μm (PM10)-induced allergic asthma mice. To establish allergic asthma with airway hyper-responsiveness by PM10, BALB/c mice were sensitized and challenged with OVA and PM10, and orally administered BHT. Histological staining was performed to assess airway remodeling. Serum and bronchoalveolar lavage fluid (BALF) was collected for measuring immunoglobulin levels and counting inflammatory cells, respectively. Expression levels of Janus kinase 1 (JAK1)/signal transducer and activator of transcription 6 (STAT6), pro-inflammatory cytokines and type 2 T-helper (Th2)-related cytokines were analyzed in vivo and in vitro models. Histopathological analysis demonstrated that BHT suppressed inflammatory cell infiltration, mucus hypersecretion and collagen deposition in the airway. BHT administration effectively decreased number of inflammatory cells in BALF. BHT reduced total serum Immunoglobulin E (IgE) and Immunoglobulin G (IgG) levels. In addition, BHT significantly inhibited the phosphorylation of JAK1 and STAT6 expressions. Release of pro-inflammatory cytokines and Th2-related cytokines were down-regulated by BHT. In conclusion, BHT mitigated airway inflammation by down-regulating pro-inflammatory and Th2-related cytokines via JAK1/STAT6 signaling. BHT might be a promising herbal medicine for preventing airway inflammation. Moreover, an intervention study among humans is needed to further evaluate the possible beneficial effects of BHT in allergic asthma. Full article
(This article belongs to the Special Issue Natural Products as Anti-inflammatory and Immunomodulatory Drugs)
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Review

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20 pages, 1589 KiB  
Review
Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders
by Roghayeh Shahbazi, Hamed Yasavoli-Sharahi, Nawal Alsadi, Nafissa Ismail and Chantal Matar
Molecules 2020, 25(21), 4891; https://doi.org/10.3390/molecules25214891 - 22 Oct 2020
Cited by 56 | Viewed by 9121
Abstract
Inflammation is a biological response to the activation of the immune system by various infectious or non-infectious agents, which may lead to tissue damage and various diseases. Gut commensal bacteria maintain a symbiotic relationship with the host and display a critical function in [...] Read more.
Inflammation is a biological response to the activation of the immune system by various infectious or non-infectious agents, which may lead to tissue damage and various diseases. Gut commensal bacteria maintain a symbiotic relationship with the host and display a critical function in the homeostasis of the host immune system. Disturbance to the gut microbiota leads to immune dysfunction both locally and at distant sites, which causes inflammatory conditions not only in the intestine but also in the other organs such as lungs and brain, and may induce a disease state. Probiotics are well known to reinforce immunity and counteract inflammation by restoring symbiosis within the gut microbiota. As a result, probiotics protect against various diseases, including respiratory infections and neuroinflammatory disorders. A growing body of research supports the beneficial role of probiotics in lung and mental health through modulating the gut-lung and gut-brain axes. In the current paper, we discuss the potential role of probiotics in the treatment of viral respiratory infections, including the COVID-19 disease, as major public health crisis in 2020, and influenza virus infection, as well as treatment of neurological disorders like multiple sclerosis and other mental illnesses. Full article
(This article belongs to the Special Issue Natural Products as Anti-inflammatory and Immunomodulatory Drugs)
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