Antimalarial Agents: Design, Synthesis and Biological Evaluation

Dear Colleagues,

Malaria is still a crucial problem worldwide, in spite of the significant research progress made. A new vaccine that doubtlessly will save lives is now being implemented in several countries, but this will not be enough to eliminate the disease in many regions. Therefore, newer vaccines that might overcome the deficiencies of the one currently available are years away. Policy changes regarding the use of drug combinations, especially artemisinin combination therapies (ACTs), as well as implementation of these policies have swept through much of the malarious world, but resistance has emerged against these drugs. Thus, the discovery and development of new drugs that overcome the mechanisms of resistance to the currently used antimalarial therapies remain a necessity until we actually accomplish the worldwide eradication of the various human malaria parasites. This Special Issue is intended to allow researchers to describe efforts toward discovering and developing new antimalarial drugs as well as new approaches to overcome resistance to the existing drugs.

Prof. David H. Peyton
Guest Editor

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