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Nanogels: Synthesis, Characterization and Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 8908

Special Issue Editors


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Guest Editor
Sorbonne Université—Campus Pierre et Marie Curie (Formerly UPMC), PHENIX (Physicochimie des Electrolytes et des Nanosystèmes Interfaciaux), Inorganic Colloids Team (CIN Team), 4 Place Jussieu, CEDEX 05, 75252 Paris, France
Interests: nanoparticles; nanoscience; polymerization

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Guest Editor
CNRS Centre National de la Recherche Scientifique, Paris, France
Interests: nanomaterials; polymers; thin films; nanoparticle synthesis; drug delivery

Special Issue Information

Dear Colleagues,

We propose a Special Issue on Nanogels: Synthesis, Characterization, and Applications to gather scientists working on the design and characterization of nanogels used in drug delivery, biomaterials, imaging, microfluidics, and sensors.

Nanogels are three-dimensional materials formed by cross-linked polymer networks at the nanometric scale. They have a high capacity to hold water, without actually dissolving into the aqueous medium. They can be synthesized using controlled living polymerizations in organic solvents or in water. They can be easily combined with inorganic nanomaterials to obtain hybrid materials with novel interesting properties. This opens the door to novel interesting applications using the physical and chemical properties of these hybrids (possibility to use pH, ionic or temperature-sensitive polymers, possibility to apply external stimulus, etc.)

The versatility of synthetic processes of nanogels, how they can be characterized, and where they can be applied requires a Special Issue to present and discuss the most recent results and trends. This issue is will present all the communities working on nanogels with a chemical, physical, and biological approaches and how these nanogels could be used in the future.

Dr. Nébéwia Griffete
Dr. Jerome Fresnais
Guest Editors

Manuscript Submission Information

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Keywords

  • Crosslinking
  • Sensors
  • Drug delivery
  • Stimuli responsiveness
  • Hybrid materials
  • Imaging
  • Microfluidics

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Published Papers (2 papers)

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Research

13 pages, 3395 KiB  
Communication
Protein Denaturation Through the Use of Magnetic Molecularly Imprinted Polymer Nanoparticles
by Charlotte Boitard, Aude Michel, Christine Ménager and Nébéwia Griffete
Molecules 2021, 26(13), 3980; https://doi.org/10.3390/molecules26133980 - 29 Jun 2021
Cited by 4 | Viewed by 2705
Abstract
The inhibition of the protein function for therapeutic applications remains challenging despite progress these past years. While the targeting application of molecularly imprinted polymer are in their infancy, no use was ever made of their magnetic hyperthermia properties to damage proteins when they [...] Read more.
The inhibition of the protein function for therapeutic applications remains challenging despite progress these past years. While the targeting application of molecularly imprinted polymer are in their infancy, no use was ever made of their magnetic hyperthermia properties to damage proteins when they are coupled to magnetic nanoparticles. Therefore, we have developed a facile and effective method to synthesize magnetic molecularly imprinted polymer nanoparticles using the green fluorescent protein (GFP) as the template, a bulk imprinting of proteins combined with a grafting approach onto maghemite nanoparticles. The hybrid material exhibits very high adsorption capacities and very strong affinity constants towards GFP. We show that the heat generated locally upon alternative magnetic field is responsible of the decrease of fluorescence intensity. Full article
(This article belongs to the Special Issue Nanogels: Synthesis, Characterization and Applications)
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15 pages, 3458 KiB  
Article
Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation
by Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp and Luis Javier Cruz
Molecules 2020, 25(9), 2219; https://doi.org/10.3390/molecules25092219 - 8 May 2020
Cited by 22 | Viewed by 5344
Abstract
(1) Background: doxorubicin is a potent chemotherapeutic agent, but it has limitations regarding its side effects and therapy resistance. Hydrogels potentially deal with these problems, but several characterizations need to be optimized to better understand how hydrogel assisted chemotherapy works. Poloxamer 407 (P407) [...] Read more.
(1) Background: doxorubicin is a potent chemotherapeutic agent, but it has limitations regarding its side effects and therapy resistance. Hydrogels potentially deal with these problems, but several characterizations need to be optimized to better understand how hydrogel assisted chemotherapy works. Poloxamer 407 (P407) hydrogels were mixed with doxorubicin and physico-chemical, biological, and pharmacological characterizations were considered. (2) Methods: hydrogels were prepared by mixing P407 in PBS at 4 °C. Doxorubicin was added upon solutions became clear. Time-to-gelation, hydrogel morphology, and micelles were studied first. The effects of P407-doxorubicin were evaluated on MC-38 colon cancer cells. Furthermore, doxorubicin release was assessed and contrasted with non-invasive in vivo whole body fluorescence imaging. (3) Results: 25% P407 had favorable gelation properties with pore sizes of 30–180 µm. P407 micelles were approximately 5 nm in size. Doxorubicin was fully released in vitro from 25% P407 hydrogel within 120 h. Furthermore, P407 micelles strongly enhanced the anti-neoplastic effects of doxorubicin on MC-38 cells. In vivo fluorescence imaging revealed that hydrogels retained fluorescence signals at the injection site for 168 h. (4) Conclusions: non-invasive imaging showed how P407 gels retained drug at the injection site. Doxorubicin P407 micelles strongly enhanced the anti-tumor effects. Full article
(This article belongs to the Special Issue Nanogels: Synthesis, Characterization and Applications)
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