Natural Organic Substances as Starting Bricks for the Semi-synthesis of New Compounds II
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (1 July 2023) | Viewed by 2376
Special Issue Editors
Interests: HPLC and NMR analysis; phytochemistry; synthesis of natural products; chemotaxonomy; ethnopharmacology; nutraceutics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are pleased to invite you to contribute to this Special Issue, which is a continuation from a very successful Volume I on the topic of “Natural Organic Substances as Starting Bricks for the Semi-Synthesis of New Compounds”.
The main objective of this Special Issue is to collect and disseminate papers on the concept of using natural products as starting bases for the semi-synthesis of new compounds.
Compounds based on natural products have proven to be an important and interesting tool to remedy two specific limitations often associated with natural products, i.e., their little recovery from natural sources, plants, and so on, and their little pharmacological effects due to general, pharmacokinetic, and pharmacodynamic problems.
The main and probably most well-known example in the former context is surely that of taxol. In fact, the decision to obtain it through a semi-synthesis process from 10-deacetylbaccatin III has made history in the field and serves as an inspiration for this Special Issue, which will focus on examining the potential of this approach In particular, the goal of the issue is to highlight how often a simple and safe semi-synthetic procedure can greatly increase the potential of natural organic compounds as pharmacologically active substances in contrast to being used as recovered from their natural sources. A typical example of this is salicylic acid and acetyl–salicylic acid. There are no restrictions regarding the kind of compounds and the pharmacological effects studied, but the differences in the pharmacological activity between the natural compound and its semi-synthetic derivative or derivatives must be shown and explained.
Dr. Claudio Frezza
Dr. Marco Franceschin
Guest Editors
Manuscript Submission Information
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Keywords
- natural products
- plant sources
- isolation
- semi-synthesis
- active substances
- pharmacology
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