Natural and Synthetic Compounds with Antioxidant Properties in Biological Systems
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 38615
Special Issue Editors
Interests: NAFLD; thyroid hormones; lipid metabolism; dietary polyphenols; antioxidant molecules
Interests: organic synthesis; multicomponent reactions; polyphenols; medicinal chemistry
Interests: diversity oriented synthesis; heterogeneous catalyst; photooxidation; bio-based resources
Interests: nutrition and metabolism; nutrition and stress; physiology of stress; Psychoneuroendocrineimmunology (PNEI)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are living in a oxidative atmosphere, thus promoting oxidation of organic and inorganic compounds. Some key biological reactions are based on oxidative processes catalyzed by metalloproteins such as iron-containing cytochromes of the mitochondrial respiratory chain. In living organisms, oxidative stress occurs from the imbalance between reactive oxygen and nitrogen species and the activity/amount of antioxidant defenses.
Several natural molecules are able to counteract and/or prevent this tendency to oxidation, thus increasing the antioxidant arsenal. The consumption of some food categories such as fruits and vegetables is widely recognized as beneficial for human health.
Oxidative stress is not to be underestimated since it constitutes the common denominator of a variety of pathologies encompassing metabolic disorders, cardiovascular and neurodegenerative diseases, cellular aging, inflammatory conditions and cancer.
Synthetic compounds, obtained by modification of natural products, are generally prepared for ameliorating pharmacokinetic properties and biological activities and overcoming poor drug-likeness. On the other hand, a powerful strategy for improving the efficiency, is the synthesis of de novo natural-based compounds. Following this approach, short and smart synthetic sequences can be designed, generating molecular complexity, providing new molecular entities inspired by natural products with different scaffolds.
Therefore, the aim of this issue is to provide new insights into the biological effects of natural or synthetic antioxidant molecules. Research papers describing the extraction or synthesis of new antioxidant compounds, their structural characterization and demonstration of beneficial effects in biological systems, either in vitro or in vivo, are welcome. Similarly, narrative or systematic reviews on biological activities of selected antioxidant molecules are appreciated.
Prof. Dr. Chiara Lambruschini
Prof. Dr. Lisa Moni
Prof. Dr. Elena Grasselli
Prof. Dr. Ilaria Demori
Guest Editors
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Keywords
- Antioxidant compounds
- Metabolic disorders
- Cardiovascular diseases
- Neurodegenerative diseases
- Inflammation
- Aging
- Natural compounds
- Synthetic compounds
- Polyphenols
- Vitamins
- Organic synthesis
- Structure–activity relationship (SAR)
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