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Antibacterial and Physical Properties of Smart Materials with Novel pH-Sensitive...
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Antibacterial and Physical Properties of Smart Materials with Novel pH-Sensitive Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 4917

Special Issue Editor

Prof. Dr. Fusun Ozer

E-Mail Website
Guest Editor
Department of Preventative and Restorative Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Interests: dental materials; resin bonding agents; physical properties; antibacterial properties; caries prevention; drug carrier compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, the use of antibiotics has taken a significant step toward preventing the propagation of bacterial pathogens. However, the rise of multidrug-resistant bacteria poses a new challenge that contributes to higher treatment failure. Progress has been made toward alternative therapeutics toward bacterial infections, including a number of pH-responsive compounds that have the ability to provide targeted and controlled antibacterial activity. Smart materials with antimicrobial efficacy are especially advantageous as they generate local stimuli-responsive antibacterial activity. Such materials may be a new approach to treat bacterial infection locally with reduced amounts of antibacterial agents, thus enhancing antibacterial stewardship and alleviating the risk of antibacterial resistance. In addition to the enhanced antimicrobial properties of these novel compounds, it is important to consider their physical impacts on the materials they are carried or used with as well. They need to be used without compromising the basic physicomechanical characteristics of materials. Therefore, this Special Issue of Molecules will serve as a platform for analyzing recent advances in the physical and antibacterial properties of novel pH-responsive compounds. I kindly invite you to submit contributions in the form of short communications, original research articles, and review papers.

Prof. Dr. Fusun Ozer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural compounds or derivatives
  • target treatment
  • acid-producing bacteria
  • physical properties
  • ph-sensitive
  • antibacterial activity
  • drug carrier

Published Papers (3 papers)

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Research

15 pages, 6221 KiB  
Article
Creation of a Composite Bioactive Coating with Antibacterial Effect Promising for Bone Implantation
by Elena G. Zemtsova, Lada A. Kozlova, Natalia M. Yudintceva, Daria N. Sokolova, Andrey Yu. Arbenin, Alexandra N. Ponomareva, Petr M. Korusenko, Ludmila A. Kraeva, Elizaveta V. Rogacheva and Vladimir M. Smirnov
Molecules 2023, 28(3), 1416; https://doi.org/10.3390/molecules28031416 - 02 Feb 2023
Cited by 1 | Viewed by 1203
Abstract
When creating titanium-containing bone implants, the bioactive coatings that promote their rapid engraftment are important. The engraftment rate of titanium implants with bone tissue depends significantly on the modification of the implant surface. It is achieved by changing either the relief or the [...] Read more.
When creating titanium-containing bone implants, the bioactive coatings that promote their rapid engraftment are important. The engraftment rate of titanium implants with bone tissue depends significantly on the modification of the implant surface. It is achieved by changing either the relief or the chemical composition of the surface layer, as well as a combination of these two factors. In this work, we studied the creation of composite coatings with a two-level (the micro- and nanolevel) hierarchy of the surface relief, which have bioactive and bactericidal properties, which are promising for bone implantation. Using the developed non-lithographic template electrochemical synthesis, a composite coating on titanium with a controlled surface structure was created based on an island-type TiO2 film, silver and hydroxyapatite (HAp). This TiO2/Ag/HAp composite coating has a developed surface relief at the micro- and nanolevels and has a significant cytological response and the ability to accelerate osteosynthesis, and also has an antibacterial effect. Thus, the developed biomaterial is suitable for production of dental and orthopedic implants with improved biomedical properties. Full article
(This article belongs to the Special Issue Antibacterial and Physical Properties of Smart Materials with Novel pH-Sensitive Compounds)
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11 pages, 1104 KiB  
Article
Antibacterial and Physical Properties of PVM/MA Copolymer- Incorporated Polymethyl Methacrylate as a Novel Antimicrobial Acrylic Resin Material
by Christopher Lai, Ashten Nguyen, Lynna Ye, Jessica Hao, Hyun Koo, Francis Mante and Fusun Ozer
Molecules 2022, 27(24), 8848; https://doi.org/10.3390/molecules27248848 - 13 Dec 2022
Cited by 2 | Viewed by 1374
Abstract
Polymethyl methacrylate (PMMA), an acrylic resin used in orthodontic appliances and removable dentures for its biocompatibility and esthetics, may harbor bacteria on its surface. The present study investigated a new PMMA formula with Gantrez: an antibacterial copolymer of methyl vinyl ether and maleic [...] Read more.
Polymethyl methacrylate (PMMA), an acrylic resin used in orthodontic appliances and removable dentures for its biocompatibility and esthetics, may harbor bacteria on its surface. The present study investigated a new PMMA formula with Gantrez: an antibacterial copolymer of methyl vinyl ether and maleic acid (PVM/MA). Samples were tested for mechanical properties (surface hardness, flexural strength, water sorption, and water solubility) and effects against Streptococcus mutans. Six groups (0%-control, 5%, 10%, 15%, 20%, and 25% Gantrez) of n = 12 were fabricated for physical property tests and analyzed with one-way ANOVA and Prism 6. From these results, three groups (0%, 5%, and 10% Gantrez) were selected for antibacterial tests, and data were analyzed with one-way ANOVA and Tukey’s multiple comparison test. Adding 5% and 10% Gantrez into PMMA significantly decreased S. mutans adhesion. There was no significant difference between the control vs. 5%, 10%, 15%, and 20% Gantrez (p > 0.05) for surface hardness, the control vs. 5% Gantrez (p > 0.05) for flexural strength, and the control vs. 5 and 10% Gantrez for water sorption and water solubility. Overall, incorporating 5% Gantrez into PMMA may be a promising solution to reduce bacterial adhesion without changing the acrylic resin’s physical properties. Full article
(This article belongs to the Special Issue Antibacterial and Physical Properties of Smart Materials with Novel pH-Sensitive Compounds)
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11 pages, 10049 KiB  
Article
Fabrication of pH-Responsive Zn2+-Releasing Glass Particles for Smart Antibacterial Restoratives
by Fan Deng, Hirohiko Sakai, Haruaki Kitagawa, Tomoki Kohno, Pasiree Thongthai, Yuhan Liu, Ranna Kitagawa, Gabriela L. Abe, Jun-ichi Sasaki and Satoshi Imazato
Molecules 2022, 27(21), 7202; https://doi.org/10.3390/molecules27217202 - 24 Oct 2022
Cited by 2 | Viewed by 1690
Abstract
The on-demand release of antibacterial components due to pH variations caused by acidogenic/cariogenic bacteria is a possible design for smart antibacterial restorative materials. This study aimed to fabricate pH-responsive Zn2+-releasing glass particles and evaluate their solubilities, ion-releasing characteristics, and antibacterial properties [...] Read more.
The on-demand release of antibacterial components due to pH variations caused by acidogenic/cariogenic bacteria is a possible design for smart antibacterial restorative materials. This study aimed to fabricate pH-responsive Zn2+-releasing glass particles and evaluate their solubilities, ion-releasing characteristics, and antibacterial properties in vitro. Three kinds of silicate-based glass particles containing different molar ratios of Zn (PG-1: 25.3; PG-2: 34.6; PG-3: 42.7 mol%) were fabricated. Each particle was immersed in a pH-adjusted medium, and the solubility and concentration of the released ions were determined. To evaluate the antibacterial effect, Streptococcus mutans was cultured in the pH-adjusted medium in the presence of each particle, and the bacterial number was counted. The solubility and concentration of Zn2+ released in the medium increased with a decrease in medium pH. PG-3 with a greater content of Zn demonstrated higher concentrations of released Zn2+ compared with PG-1 and PG-2. PG-2 exhibited bactericidal effects at pH 5.1, whereas PG-3 demonstrated bactericidal effects at pH values of 5.1 and 6.1, indicating that PG-3 was effective at inhibiting S. mutans even under slightly acidic conditions. The glass particle with 42.7 mol% Zn may be useful for developing smart antibacterial restoratives that contribute to the prevention of diseases such as caries on root surfaces with lower acid resistance. Full article
(This article belongs to the Special Issue Antibacterial and Physical Properties of Smart Materials with Novel pH-Sensitive Compounds)
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