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State-of-the-Art Ultra-Low Field Techniques and Magnetic Nanoprobe for the Application...
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State-of-the-Art Ultra-Low Field Techniques and Magnetic Nanoprobe for the Application on Biochemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 4190

Special Issue Editors

Prof. Dr. Li Yao

E-Mail Website
Guest Editor
Institute of Chemistry Chinese Academy of Sciences, Zhongguancun North First Street 2, Beijing 100190, China
Interests: nanobiotechnology; ultro-low-field detection; force spectroscopy; magnetic nanoprober; magnetic imaging; magnetic nanoparticles; bacterial adhesion; cancer metastasis; biomechanics
Prof. Dr. Jianfeng Zeng

E-Mail Website
Guest Editor
School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou, China
Interests: design, synthesis, and application of molecular imaging nanoprobes and radiopharmaceuticals; translation medicine of nanodrugs

Special Issue Information

Dear Colleagues,

Magnetic nanoprobes have great potential in biochemical applications, because of their biocompatibility, magnetism responsiveness, and favorable biomolecule-comparable sizes. The development of ultra-low field (ULF) techniques allows for the direct detection of in situ magnetic nanoprobes because of the low magnetic background of biological samples, which enables highly sensitive sensing and imaging. Recent developments of ULF techniques include giant magnetoresistance sensors, superconducting quantum interference devices, atomic magnetometers and magnetic particle imaging, among others. The precise determination of the position and quantity of the magnetic nanoprobes is critical for their chemical and biological applications.

This Special Issue aims to provide a broad overview of the most recent developments in ULF techniques and magnetic nanoprobes for their application in biochemistry. Contributions (including full papers, communications and reviews) concerning reports or overviews on new methodologies, techniques, or materials in the biochemical applications of ULF techniques or magnetic nanoprobes are welcome.

Prof. Dr. Li Yao
Prof. Dr. Jianfeng Zeng 
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnetic nanoprobe 
  • ultra-low magnetic field 
  • biosensor 
  • imaging 
  • biochemistry

Published Papers (2 papers)

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Research

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13 pages, 4661 KiB  
Article
Functionalized Ultrasmall Iron Oxide Nanoparticles for T1-Weighted Magnetic Resonance Imaging of Tumor Hypoxia
by Lei Yang, Mohammad Javad Afshari, Jianxian Ge, Dandan Kou, Lei Chen, Dandan Zhou, Cang Li, Shuwang Wu, Leshuai Zhang, Jianfeng Zeng, Jian Zhong, Roland H. Stauber and Mingyuan Gao
Molecules 2022, 27(20), 6929; https://doi.org/10.3390/molecules27206929 - 15 Oct 2022
Cited by 6 | Viewed by 2050
Abstract
Hypoxia is a common biological condition in many malignant solid tumors that plays an imperative role in regulating tumor growth and impacting the treatment’s therapeutic effect. Therefore, the hypoxia assessment is of great significance in predicting tumor development and evaluating its prognosis. Among [...] Read more.
Hypoxia is a common biological condition in many malignant solid tumors that plays an imperative role in regulating tumor growth and impacting the treatment’s therapeutic effect. Therefore, the hypoxia assessment is of great significance in predicting tumor development and evaluating its prognosis. Among the plenty of existing tumor diagnosis techniques, magnetic resonance imaging (MRI) offers certain distinctive features, such as being free of ionizing radiation and providing images with a high spatial resolution. In this study, we develop a fluorescent traceable and hypoxia-sensitive T1-weighted MRI probe (Fe3O4-Met-Cy5.5) via conjugating notable hypoxia-sensitive metronidazole moiety and Cy5.5 dye with ultrasmall iron oxide (Fe3O4) nanoparticles. The results of in vitro and in vivo experiments show that Fe3O4-Met-Cy5.5 has excellent performance in relaxivity, biocompatibility, and hypoxia specificity. More importantly, the obvious signal enhancement in hypoxic areas indicates that the probe has great feasibility for sensing tumor hypoxia via T1-weighted MRI. These promising results may unlock the potential of Fe3O4 nanoparticles as T1-weighted contrast agents for the development of clinical hypoxia probes. Full article
(This article belongs to the Special Issue State-of-the-Art Ultra-Low Field Techniques and Magnetic Nanoprobe for the Application on Biochemistry)
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Review

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9 pages, 1412 KiB  
Review
Advances in the Biological Application of Force-Induced Remnant Magnetization Spectroscopy
by Shuyu Liao, Mengxue Sun, Jinxiu Zhan, Min Xu and Li Yao
Molecules 2022, 27(7), 2072; https://doi.org/10.3390/molecules27072072 - 23 Mar 2022
Viewed by 1538
Abstract
Biomolecules participate in various physiological and pathological processes through intermolecular interactions generally driven by non-covalent forces. In the present review, the force-induced remnant magnetization spectroscopy (FIRMS) is described and illustrated as a novel method to measure non-covalent forces. During the FIRMS measurement, the [...] Read more.
Biomolecules participate in various physiological and pathological processes through intermolecular interactions generally driven by non-covalent forces. In the present review, the force-induced remnant magnetization spectroscopy (FIRMS) is described and illustrated as a novel method to measure non-covalent forces. During the FIRMS measurement, the molecular magnetic probes are magnetized to produce an overall magnetization signal. The dissociation under the interference of external force yields a decrease in the magnetic signal, which is recorded and collected by atomic magnetometer in a spectrum to study the biological interactions. Furthermore, the recent FIRMS development with various external mechanical forces and magnetic probes is summarized. Full article
(This article belongs to the Special Issue State-of-the-Art Ultra-Low Field Techniques and Magnetic Nanoprobe for the Application on Biochemistry)
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