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Nanomaterials
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Organic and Inorganic Nanostructured Composites for Medical Application
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Organic and Inorganic Nanostructured Composites for Medical Application

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Nanocomposite Materials".

Deadline for manuscript submissions: closed (30 March 2024) | Viewed by 7877

Special Issue Editors

Dr. Andrea Zille

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Guest Editor
2C2T-Centro de Ciência e Tecnologia Têxtil, Universidade do Minho, Campus de Azurém, 4800-058 Guimarães, Portugal
Interests: textile coating and functionalization; medical textiles; biomaterials; nanomaterials; plasma functionalization
Special Issues, Collections and Topics in MDPI journals
Dr. Jorge Padrão

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Guest Editor
Centre for Textile Science and Technology (2C2T), University of Minho, 4800-058 Guimarães, Portugal
Interests: textile materials; biotechnology; biomaterials; antimicrobials; bioreactor optimization; nanotechnology; environmental biotechnology; industrial biotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to invite you to submit your work to this Special Issue of Nanomaterials titled "Organic and Inorganic Nanostructured Composites for medical application". Hybrid nanocomposites made up of inorganic NPs and/or organic materials such as enzymes represent a new class of materials that exhibit improved synergistic performance when compared to their individual contributions. The surface modifications incurred to NPs by chemical treatments is a useful method through which the enzyme adhesion to NPs can be improved. Several functional groups or crosslinker molecules can be introduced to the NPs by their ligand molecules or by a mixture of different ligands. The recent combination of the disciplines of nanotechnology and biology has led to some very important theoretical and practical advances in both biology and nanoengineered materials. However, the design and synthesis of such hybrid bionanomaterials remain a challenge in terms of tailoring the structures of the bionanomaterials in response to their applications. The scope of this Special Issue is the creation of nanostructures that is not only focused on hybrid nanocomposites that are made up of both inorganic and organic materials but also on the new advanced combination of organic polymers and organic nanoparticles when trying to avoid the use of metal or metal oxides. In particular, topics of interest include but are not limited to:

  • Enzyme-organic/inorganic hybrid nanomaterials;
  • Organic nanoparticle composites (e.g., celulose/lignin, polymer/protein, etc.)
  • Metal-organic frameworks (MOFs);
  • Bioorganic and bioinorganic chemistry;
  • Bionanotechnology in biocatalysis and drug delivery;
  • Bioremediations applications;
  • Nanobiosensors;
  • Antimicrobial and antifouling applications;
  • Applications in biotechnology, immunosensing and biomedical areas;
  • Nanoparticle-protein conjugates as biolabels.

Dr. Andrea Zille
Dr. Jorge Padrão
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoscruture
  • nanoparticles
  • organic/inorganic nanoparticles
  • enzymes
  • bionanotechnology
  • biopolymers

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Published Papers (3 papers)

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Research

15 pages, 2698 KiB  
Article
Boron Nanoparticle-Enhanced Proton Therapy for Cancer Treatment
by Irina N. Zavestovskaya, Anton L. Popov, Danil D. Kolmanovich, Gleb V. Tikhonowski, Andrei I. Pastukhov, Maxim S. Savinov, Pavel V. Shakhov, Julia S. Babkova, Anton A. Popov, Ivan V. Zelepukin, Maria S. Grigoryeva, Alexander E. Shemyakov, Sergey M. Klimentov, Vladimir A. Ryabov, Paras N. Prasad, Sergey M. Deyev and Andrei V. Kabashin
Nanomaterials 2023, 13(15), 2167; https://doi.org/10.3390/nano13152167 - 26 Jul 2023
Cited by 11 | Viewed by 2599
Abstract
Proton therapy is one of the promising radiotherapy modalities for the treatment of deep-seated and unresectable tumors, and its efficiency can further be enhanced by using boron-containing substances. Here, we explore the use of elemental boron (B) nanoparticles (NPs) as sensitizers for proton [...] Read more.
Proton therapy is one of the promising radiotherapy modalities for the treatment of deep-seated and unresectable tumors, and its efficiency can further be enhanced by using boron-containing substances. Here, we explore the use of elemental boron (B) nanoparticles (NPs) as sensitizers for proton therapy enhancement. Prepared by methods of pulsed laser ablation in water, the used B NPs had a mean size of 50 nm, while a subsequent functionalization of the NPs by polyethylene glycol improved their colloidal stability in buffers. Laser-synthesized B NPs were efficiently absorbed by MNNG/Hos human osteosarcoma cells and did not demonstrate any remarkable toxicity effects up to concentrations of 100 ppm, as followed from the results of the MTT and clonogenic assay tests. Then, we assessed the efficiency of B NPs as sensitizers of cancer cell death under irradiation by a 160.5 MeV proton beam. The irradiation of MNNG/Hos cells at a dose of 3 Gy in the presence of 80 and 100 ppm of B NPs led to a 2- and 2.7-fold decrease in the number of formed cell colonies compared to control samples irradiated in the absence of NPs. The obtained data unambiguously evidenced the effect of a strong proton therapy enhancement mediated by B NPs. We also found that the proton beam irradiation of B NPs leads to the generation of reactive oxygen species (ROS), which evidences a possible involvement of the non-nuclear mechanism of cancer cell death related to oxidative stress. Offering a series of advantages, including a passive targeting option and the possibility of additional theranostic functionalities based on the intrinsic properties of B NPs (e.g., photothermal therapy or neutron boron capture therapy), the proposed concept promises a major advancement in proton beam-based cancer treatment. Full article
(This article belongs to the Special Issue Organic and Inorganic Nanostructured Composites for Medical Application)
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14 pages, 13322 KiB  
Article
Can Superhydrophobic PET Surfaces Prevent Bacterial Adhesion?
by Tugce Caykara, Sara Fernandes, Adelaide Braga, Joana Rodrigues, Ligia R. Rodrigues and Carla Joana Silva
Nanomaterials 2023, 13(6), 1117; https://doi.org/10.3390/nano13061117 - 21 Mar 2023
Cited by 4 | Viewed by 2073
Abstract
Prevention of bacterial adhesion is a way to reduce and/or avoid biofilm formation, thus restraining its associated infections. The development of repellent anti-adhesive surfaces, such as superhydrophobic surfaces, can be a strategy to avoid bacterial adhesion. In this study, a polyethylene terephthalate (PET) [...] Read more.
Prevention of bacterial adhesion is a way to reduce and/or avoid biofilm formation, thus restraining its associated infections. The development of repellent anti-adhesive surfaces, such as superhydrophobic surfaces, can be a strategy to avoid bacterial adhesion. In this study, a polyethylene terephthalate (PET) film was modified by in situ growth of silica nanoparticles (NPs) to create a rough surface. The surface was further modified with fluorinated carbon chains to increase its hydrophobicity. The modified PET surfaces presented a pronounced superhydrophobic character, showing a water contact angle of 156° and a roughness of 104 nm (a considerable increase comparing with the 69° and 4.8 nm obtained for the untreated PET). Scanning Electron Microscopy was used to evaluate the modified surfaces morphology, further confirming its successful modification with nanoparticles. Additionally, a bacterial adhesion assay using an Escherichia coli expressing YadA, an adhesive protein from Yersinia so-called Yersinia adhesin A, was used to assess the anti-adhesive potential of the modified PET. Contrarily to what was expected, adhesion of E. coli YadA was found to increase on the modified PET surfaces, exhibiting a clear preference for the crevices. This study highlights the role of material micro topography as an important attribute when considering bacterial adhesion. Full article
(This article belongs to the Special Issue Organic and Inorganic Nanostructured Composites for Medical Application)
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19 pages, 5828 KiB  
Article
Antibacterial Bio-Nanocomposite Textile Material Produced from Natural Resources
by Darka Marković, Andrea Zille, Ana Isabel Ribeiro, Daiva Mikučioniene, Barbara Simončič, Brigita Tomšič and Maja Radetić
Nanomaterials 2022, 12(15), 2539; https://doi.org/10.3390/nano12152539 - 24 Jul 2022
Cited by 1 | Viewed by 2381
Abstract
Growing demand for sustainable and green technologies has turned industries and research toward the more efficient utilization of natural and renewable resources. In an effort to tackle this issue, we developed an antibacterial textile nanocomposite material based on cotton and peat fibers with [...] Read more.
Growing demand for sustainable and green technologies has turned industries and research toward the more efficient utilization of natural and renewable resources. In an effort to tackle this issue, we developed an antibacterial textile nanocomposite material based on cotton and peat fibers with immobilized Cu-based nanostructures. In order to overcome poor wettability and affinity for Cu2+-ions, the substrate was activated by corona discharge and coated with the biopolymer chitosan before the in situ synthesis of nanostructures. Field emission scanning electron microscopy (FESEM) images show that the application of gallic or ascorbic acid as green reducing agents resulted in the formation of Cu-based nanosheets and mostly spherical nanoparticles, respectively. X-ray photoelectron spectroscopy (XPS) analysis revealed that the formed nanostructures consisted of Cu2O and CuO. A higher-concentration precursor solution led to higher copper content in the nanocomposites, independent of the reducing agent and chitosan deacetylation degree. Most of the synthesized nanocomposites provided maximum reduction of the bacteria Escherichia coli and Staphylococcus aureus. A combined modification using chitosan with a higher deacetylation degree, a 1 mM solution of CuSO4 solution, and gallic acid resulted in an optimal textile nanocomposite with strong antibacterial activity and moderate Cu2+-ion release in physiological solutions. Finally, the Cu-based nanostructures partially suppressed the biodegradation of the textile nanocomposite in soil. Full article
(This article belongs to the Special Issue Organic and Inorganic Nanostructured Composites for Medical Application)
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