Carbon-Based Nanomaterials for Biomedicine Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "2D and Carbon Nanomaterials".

Deadline for manuscript submissions: 10 November 2024 | Viewed by 3025

Special Issue Editor


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Guest Editor
Institut de Chimie Physique, CNRS–UMR 8000, Université Paris-Saclay, Gif-sur-Yvette, France
Interests: fullerenes; pharmacy; clinical biology; analytical chemistry
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Special Issue Information

Dear Colleagues,

As you know, nearly half a century after the discovery of fullerenes, countless publications have been devoted to the potential biomedical applications of carbon nanoparticles (CNPs), including nanotubes, nanohorns and, more recently, graphene. However, no such drug or medical device has yet legally entered the market. Obviously, it was the fear of the alleged dangers of CNPs instilled by certain authors in 2000 after the National Nanotechnology Initiative (NNI) in the USA, which was immediately spread by the media of the time, that was responsible for the sudden halt in the development of CNPs in the biomedical field and, even more seriously, the subsequent mistrust and disinterest of the pharmaceutical industry. Admittedly, the NNI originally called for investment in all S&T fields except toxicology and environmental impact.

Since then, it has taken several years for the scientific community to confirm that the toxicity observed with certain fullerene preparations can only be attributed to the impurities present in these preparations. Nevertheless, there is still a long way to go because, as with any drug candidate, the safety of each new CNP and/or formulation, as well as its fate in a living organism (ADME), must be tested before entering clinical trials.

The aim of this Special Issue is to provide a platform for expert groups, as well as young researchers, in this field to discuss the state of the art regarding the use of CNPs for diagnostic and/or therapeutic purposes. The underlying goal is to provide a springboard for renewed interest from researchers and potential investors in the healthcare sector.

All submissions, including, of course, those reporting proven toxic effects, in the form of research papers, analyses, commentaries, etc., will be accepted after peer review.

Prof. Dr. Fathi Moussa
Guest Editor

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Keywords

  • carbon nanoparticles
  • fullerenes
  • nanotubes
  • nanohorns
  • graphene
  • biomedical applications

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Published Papers (2 papers)

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Research

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19 pages, 5369 KiB  
Article
What Are the Key Factors for the Detection of Peptides Using Mass Spectrometry on Boron-Doped Diamond Surfaces?
by Juvissan Aguedo, Marian Vojs, Martin Vrška, Marek Nemcovic, Zuzana Pakanova, Katerina Aubrechtova Dragounova, Oleksandr Romanyuk, Alexander Kromka, Marian Varga, Michal Hatala, Marian Marton and Jan Tkac
Nanomaterials 2024, 14(15), 1241; https://doi.org/10.3390/nano14151241 - 24 Jul 2024
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Abstract
We investigated the use of boron-doped diamond (BDD) with different surface morphologies for the enhanced detection of nine different peptides by matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS). For the first time, we compared three different nanostructured BDD film morphologies (Continuous, Nanograss, and Nanotips) [...] Read more.
We investigated the use of boron-doped diamond (BDD) with different surface morphologies for the enhanced detection of nine different peptides by matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS). For the first time, we compared three different nanostructured BDD film morphologies (Continuous, Nanograss, and Nanotips) with differently terminated surfaces (-H, -O, and -F) to commercially available Ground Steel plates. All these surfaces were evaluated for their effectiveness in detecting the nine different peptides by MALDI-MS. Our results demonstrated that certain nanostructured BDD surfaces exhibited superior performance for the detection of especially hydrophobic peptides (e.g., bradykinin 1–7, substance P, and the renin substrate), with a limit of detection of down to 2.3 pM. Further investigation showed that hydrophobic peptides (e.g., bradykinin 1–7, substance P, and the renin substrate) were effectively detected on hydrogen-terminated BDD surfaces. On the other hand, the highly acidic negatively charged peptide adrenocorticotropic hormone fragment 18–39 was effectively identified on oxygen-/fluorine-terminated BDD surfaces. Furthermore, BDD surfaces reduced sodium adduct contamination significantly. Full article
(This article belongs to the Special Issue Carbon-Based Nanomaterials for Biomedicine Applications)
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Review

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17 pages, 1137 KiB  
Review
Exploring the Application of Graphene Oxide-Based Nanomaterials in the Repair of Osteoporotic Fractures
by Hongfa Zhou, Jinyuan Chen, Xuan Zhang, JingJing Chen, Jiayou Chen, Shicheng Jia, Deli Wang, Hui Zeng, Jian Weng and Fei Yu
Nanomaterials 2024, 14(6), 553; https://doi.org/10.3390/nano14060553 - 21 Mar 2024
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Abstract
Osteoporotic fractures are induced by osteoporosis, which may lead to the degradation of bone tissues and microstructures and impair their healing ability. Conventional internal fixation therapies are ineffective in the treatment of osteoporotic fractures. Hence, developing tissue engineering materials is crucial for repairing [...] Read more.
Osteoporotic fractures are induced by osteoporosis, which may lead to the degradation of bone tissues and microstructures and impair their healing ability. Conventional internal fixation therapies are ineffective in the treatment of osteoporotic fractures. Hence, developing tissue engineering materials is crucial for repairing osteoporotic fractures. It has been demonstrated that nanomaterials, particularly graphene oxide (GO), possess unique advantages in tissue engineering due to their excellent biocompatibility, mechanical properties, and osteoinductive abilities. Based on that, GO-nanocomposites have garnered significant attention and hold promising prospects for bone repair applications. This paper provides a comprehensive insight into the properties of GO, preparation methods for nanocomposites, advantages of these materials, and relevant mechanisms for osteoporotic fracture applications. Full article
(This article belongs to the Special Issue Carbon-Based Nanomaterials for Biomedicine Applications)
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