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Relevance and Safe Utilization of Amino Acids in Dietary Supplements

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Proteins and Amino Acids".

Deadline for manuscript submissions: 20 June 2026 | Viewed by 1134

Special Issue Editor


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Guest Editor
UMR-PNCA, Université Paris-Saclay, AgroParisTech, INRAE, 91120 Palaiseau, France
Interests: nutrition; amino acid gastroenterology; nitrogen metabolism; proteins

Special Issue Information

Dear Colleagues,

We present a Special Issue of Nutrients on the “Relevance and Safe Utilization of Amino Acids in Dietary Supplements”.

Amino acid supplementation may be recommended in healthy individuals who present with a deficiency of one or more amino acids in the dietary proteins that humans consume. Clinical and experimental studies also focus on specific physiological and pathophysiological situations where the requirement for specific amino acids increases, such as attaining optimal metabolic and physiological functions.

However, there is a major concern regarding supplements with amino acid contents above the tolerable upper intake level (UL), defined as the highest level of daily amino acid intake that is likely to pose no adverse effects on consumer health.

Based on this context, we invite contributions to this Nutrients SI which will gather original reports from clinical trials aimed at documenting the efficiency of supplementation with specific amino acids in different situations, as well as the doses of specific amino acids which must not be exceeded in supplements for user safety. Original reports from experimental studies deciphering the mechanisms involved and the effects of amino acid supplements are also welcome. Contributors are encouraged to submit review papers dedicated to these topics.

I look forward to receiving your contribution.

Dr. François Blachier
Guest Editor

Manuscript Submission Information

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Keywords

  • amino acids
  • dietary supplements
  • tolerable upper intake level
  • physiological relevance
  • pathophysiology

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Published Papers (1 paper)

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Review

33 pages, 1456 KB  
Review
Relevance and Safe Utilization of Amino Acids in Supplements for Human Nutrition: Lessons from Clinical and Preclinical Studies
by François Blachier
Nutrients 2026, 18(2), 296; https://doi.org/10.3390/nu18020296 - 17 Jan 2026
Viewed by 867
Abstract
Amino acid availability is central for the synthesis of macromolecules and numerous bioactive compounds. Amino acids are also involved in ATP production, cell signaling, and the epigenetic regulation of gene expression in human cells. From clinical and experimental studies, it appears that supplementation [...] Read more.
Amino acid availability is central for the synthesis of macromolecules and numerous bioactive compounds. Amino acids are also involved in ATP production, cell signaling, and the epigenetic regulation of gene expression in human cells. From clinical and experimental studies, it appears that supplementation with specific amino acids may be relevant to correct for amino acid deficiency in the case of insufficient supply from dietary proteins with regards to the amounts needed for optimal metabolism and physiological functions. Clinical and experimental arguments suggest that amino acid supplementation may be indicated in specific situations under a specific nutritional context. However, it is essential not to overdose with excessive quantities of amino acids in supplements beyond the upper levels of safe intake (ULSI). In this narrative review, I recapitulate the protein and amino acid requirements for the general population and for subgroups of the population, and these requirements are compared to the usual consumption. Typical examples of clinical trials showing the benefits from amino acid supplementation in different physiological and pathophysiological contexts are presented together with results obtained from experimental studies. Parameters such as the no-observed-adverse-effect-level (NOAEL) values used to determine the ULSI for amino acid supplementation are defined, and values determined in clinical trials are given and discussed. Finally, prospects for future research in the field are proposed. Full article
(This article belongs to the Special Issue Relevance and Safe Utilization of Amino Acids in Dietary Supplements)
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