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Dietary Factors and Bioactive Compounds: Implications for Glycative and Oxidative Stress

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A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (15 February 2024) | Viewed by 3835

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Dr. Chi-Hao Wu

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Department of Human Development and Family Studies, National Taiwan Normal University, Taipei 106, Taiwan
Interests: glycative stress; glycotoxin and human diseases; functional food chemistry

Special Issue Information

Dear Colleagues,

We cordially invite you to contribute to our upcoming publication on the intriguing topic on the implications of dietary factors and bioactive compound for glycative and oxidative stress. This cutting-edge collection aims to explore the intricate relationship between our dietary choices, the bioactive compounds present in foods and their profound effects on glycative and oxidative stress within the body.

Glycative and oxidative stress are emerging as crucial factors in various chronic diseases. This Special Issue seeks to uncover novel insights into how dietary components and bioactive compounds can modulate these stresses, shedding light on potential preventive and therapeutic strategies. We welcome contributions from researchers and experts in the fields of nutrition, biochemistry and health sciences to share their findings, insights and novel perspectives. By participating in this endeavour, you will contribute to advancing our understanding of how our dietary decisions can play a pivotal role in managing glycative and oxidative stress-related conditions.

We eagerly anticipate your valuable contribution to this enlightening publication.

Dr. Chi-Hao Wu
Guest Editor

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Keywords

advanced glycation end-product
dietary pattern
dietary factors
flavonoid
nutrient
phytochemical
polyphenol
reactive dicarbonyl species
reactive oxygen species

Published Papers (3 papers)

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Research

13 pages, 2310 KiB

Open AccessArticle

Partial Replacement of Diet with Dehulled Adlay Ameliorates Hepatic Steatosis, Inflammation, Oxidative Stress, and Gut Dysbiosis in Rats with Nonalcoholic Fatty Liver Disease

by Hsuan-Chih Huang, Pei-Ni Lee, Wen-Chih Huang and Hsin-Yi Yang

Nutrients 2023, 15(20), 4375; https://doi.org/10.3390/nu15204375 - 16 Oct 2023

Viewed by 1170

Abstract

The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing worldwide, and the average age at NAFLD diagnosis has been decreasing. Although some components of adlay can ameliorate lipid metabolism, oxidative stress, inflammatory response, and gut microbiota, few studies have explored the effects of the dietary intake of intact dehulled adlay on liver diseases. Therefore, in this study, we investigated the effects of the dietary intake of dehulled adlay on NAFLD progression and explored the potential underlying mechanisms. Rats were randomized into a control group; a high-fat, high-sucrose diet (60% total energy derived from fat and 9.4% from sucrose)-induced NAFLD group (N); or a high-fat, high-sucrose diet with dehulled adlay group (received the same amounts of dietary fiber and total energy as did the N group). The experimental duration was 16 weeks. The diet containing dehulled adlay mitigated hepatic fat accumulation, proinflammatory cytokine levels, and oxidative stress by regulating the AMPK-Nrf2-NLRP3 inflammasome pathway and ferroptosis. Additionally, the dietary intake of dehulled adlay modulated the composition of the gut microbiota. In conclusion, a diet containing dehulled adlay may decelerate the progression of NAFLD by ameliorating hepatic steatosis, inflammation, oxidative stress, and gut dysbiosis. Full article

(This article belongs to the Special Issue Dietary Factors and Bioactive Compounds: Implications for Glycative and Oxidative Stress)

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16 pages, 4485 KiB

Open AccessArticle

Alleviating Effects of Ovatodiolide and Antcin K Supplements on High-Fat Diet-Induced Cardiovascular Dysfunction in ApoE-Knockout Mice by Attenuating Oxidative Stress

by Chen-Wen Lu, Wen-Jhen Wu, Thi Kim Ngan Nguyen, Szu-Chuan Shen, Yeh-B. Wu, Hui-Ju Liang and Chung-Hsin Wu

Nutrients 2023, 15(18), 4074; https://doi.org/10.3390/nu15184074 - 20 Sep 2023

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Abstract

A high-fat diet (HFD) is a major risk factor for cardiovascular diseases. Many pure compounds have been demonstrated to be effective in treating cardiovascular diseases. In this study, we investigated the alleviating effects of oral ovatodiolide and antcin K (OAK) supplements on HFD-induced cardiovascular dysfunction in apolipoprotein E (ApoE)-knockout mice. Cardiovascular dysfunction was induced in ApoE-knockout mice by feeding them an HFD for 12 weeks. The degree of cardiovascular dysfunction was assessed through echocardiography, hematological and biochemical analyses, and immunofluorescence and immunohistochemical staining. The HFD-fed mice exhibited cardiovascular dysfunction—abnormal blood biochemical index. The arterial wall tissue exhibited the marked deposition of lipids, upregulated expression of vascular cell adhesion molecule-1 and CD36 receptors, and downregulated expression of the ABCA1 receptor. Macrophages isolated from the peritoneal cavity of the mice exhibited increased levels of lipid accumulation, reactive oxygen species, and CD11b expression but reduced mitochondrial membrane potential. The expression of superoxide dismutase 2 was downregulated and that of tumor necrosis factor-α was upregulated in the myocardial tissue. Oral OAK supplements twice a day for 12 weeks significantly mitigated HFD-induced cardiovascular dysfunction in the experimental mice. Oral OAK supplements appear to be a promising strategy for treating HFD-induced cardiovascular dysfunction. The underlying mechanisms may involve the reduction of lipid accumulation in the artery and oxidative stress and inflammation in the cardiovascular tissue. Full article

(This article belongs to the Special Issue Dietary Factors and Bioactive Compounds: Implications for Glycative and Oxidative Stress)

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17 pages, 1025 KiB

Open AccessArticle

Safety Assessment and Hepatic–Renal Protection of Cajanus cajan (L.) Millsp. Root and Its Soy Isoflavone Contents

by Thuy-Lan-Thi Vo, Xiang-Ming Cai, Jiunn-Wang Liao, Liang-Gie Huang, Chien-Lin Chen, Chi-Hao Wu and Tuzz-Ying Song

Nutrients 2023, 15(18), 3963; https://doi.org/10.3390/nu15183963 - 13 Sep 2023

Cited by 1 | Viewed by 1085

Abstract

Cajanus cajan (L.) Millsp., also known as pigeon pea, has roots that have exhibited much pharmacological potential. The present study was conducted to assess the safe dose of the ethanolic extract of C. cajan roots (EECR95) and to analyze the main soy isoflavones contents. In vitro, we investigated the mutagenicity and cytotoxic effect of EECR95 on Salmonella typhimurium-TA98 and TA100 (by Ames tests) and RAW 264.7, L-929, and HGF-1 cell lines (by MTT tests) for 24 h of incubation. We found no mutagenic or cytotoxic effects of EECR95. After administration of 0.2 or 1.0 g/kg bw of EECR95 to both male and female Wistar rats for 90 days, there were no significant adverse effects on the behaviors (body weight, water intake, and food intake), organ/tissue weights, or immunohistochemical staining, and the urine and hematological examinations of the rats were within normal ranges. EECR95 potentially decreases renal function markers in serum (serum uric acid, BUN, CRE, and GLU) or liver function markers (cholesterol, triglyceride, and glutamic-pyruvate-transaminase (GPT)). We also found that EECR95 contained five soy isoflavones (genistein, biochanin A, daidzein, genistin, and cajanol), which may be related to its hepatorenal protection. Based on the high dose (1.0 g/kg bw) of EECR95, a safe daily intake of EECR95 for human adults is estimated to be 972 mg/60 kg person/day. Full article

(This article belongs to the Special Issue Dietary Factors and Bioactive Compounds: Implications for Glycative and Oxidative Stress)

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