nutrients-logo

Journal Browser

Journal Browser

Food–Gut–Brain: Control of Appetite and Weight Management

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (15 October 2025) | Viewed by 2130

Special Issue Editor


E-Mail Website
Guest Editor
Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), São Paulo, Brazil
Interests: dietary and nutrition; ultra-processed food; high fat and high sugar diet; intestine-brain axis; intestinal barrier; intestine selective permeability; gut microbiota; molecular mechanisms controlling food intake; hormones, neuropeptides, and neurotransmitters involved in the regulation of food intake; weight management

Special Issue Information

Dear Colleagues,

The worldwide prevalence of individuals with obesity has doubled since 1990. In 2022, it was estimated that there were more than 1 billion people in the world who had obesity. Body fat accumulation is associated with higher mortality rates and type 2 diabetes mellitus (T2DM) development.

However, all strategies available to prevent and treat obesity, including pharmacological, surgical, dietary, and behavioral interventions, have limited efficacy.

The relevance of bidirectional interactions between the nervous system and the gastrointestinal tract is now recognized as a crucial mechanism to control energy homeostasis and the core of the pathophysiology of obesity and T2DM and other cardiometabolic diseases involving low-grade inflammatory components.

Thus, in this Special Issue, we aim to accept papers and review papers that shed light on relevant mechanisms by which diets and different kinds of foods affect the gut–brain axis, intestine hormones such as, but not limited to, glucagon-1-derived peptide (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and peptide YY (PYY), reflecting the management of appetite and body weight.

Ultra-processed foods (UPFs) are recognized drivers of the overweight and obesity epidemic, which increases the risk of morbidity and mortality. We are also interested in receiving manuscripts that approach the effects of UPFs on the gut–brain axis, gut microbiota, appetite, and weight management.

Dr. Patricia Oliveira Prada
Guest Editor

Kênia Moreno de Oliveira
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut–brain axis
  • appetite
  • weight management
  • obesity
  • nervous system
  • gastrointestinal tract
  • energy homeostasis
  • intestine hormones
  • ultra-processed foods

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

22 pages, 2167 KB  
Article
Effects of Ultra-Processed Diets on Adiposity, Gut Barrier Integrity, Inflammation, and Microbiota in Male and Female Mice
by Caroline de Menezes, Clara Machado Campolim, Angie Triana, Kênia Moreno de Oliveira, Leticia Gama S. Calixto, Fernanda Garofalo Xavier, Mario J. A. Saad, Everardo Magalhães Carneiro and Patricia O. Prada
Nutrients 2025, 17(19), 3116; https://doi.org/10.3390/nu17193116 - 30 Sep 2025
Cited by 1 | Viewed by 1656
Abstract
Background/Objectives: The consumption of highly palatable ultra-processed foods (UPFs), enriched in sugar, saturated fat, and salt, increases the risk of morbidity and mortality by inducing obesity, type 2 diabetes (T2DM), cardiovascular disease, and cancer. The present study aimed to investigate the impact of [...] Read more.
Background/Objectives: The consumption of highly palatable ultra-processed foods (UPFs), enriched in sugar, saturated fat, and salt, increases the risk of morbidity and mortality by inducing obesity, type 2 diabetes (T2DM), cardiovascular disease, and cancer. The present study aimed to investigate the impact of a UPF-rich diet on adiposity, feeding behavior, glucose homeostasis, intestinal barrier markers, expression of inflammatory cytokines, and microbiota in male and female C57BL/6J mice. Methods: Animals received a chow diet or a UPF diet for 10 (UPF10) or 30 days (UPF30). UPF10 induced greater calorie intake as early as 10 days on a UPF diet. Fat accumulation occurs in both sexes, specifically after 30 days of exposure. Results: The duration of UPF exposure significantly influenced glucose metabolism and insulin sensitivity. A 10-day UPF diet was associated with lower fasting blood glucose levels, without higher insulin levels, in both sexes. Females showed early impairment in glucose tolerance. Male mice on UPF30 exhibited elevated systemic IL-6 levels, as well as reduced intestinal expression of Occludin and E-cadherin genes. In females, UPF30 increased TNF-α expression in the gut and increased microbial diversity. Both sexes displayed dysbiosis, with females showing pronounced changes in the proportion between predominant phyla, and males showing more specific changes in bacterial genera. Conclusions: A diet high in UPFs promoted metabolic, inflammatory, and gut microbiota alterations, with effects varying according to exposure duration and biological context, and becoming more pronounced after 30 days. Full article
(This article belongs to the Special Issue Food–Gut–Brain: Control of Appetite and Weight Management)
Show Figures

Figure 1

Back to TopTop