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Nutritional Strategies for Diseases Associated with Muscle Injuries

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (5 April 2024) | Viewed by 12578

Special Issue Editors


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Guest Editor
Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, 2 Jakubowskiego St., 30-668 Krakow, Poland
Interests: older people; sarcopenia; geriatrics; muscle

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Co-Guest Editor
Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, 2 Jakubowskiego St., 30-668 Krakow, Poland
Interests: older people; sarcopenia; geriatrics; muscle

Special Issue Information

Dear Colleagues,

With the ageing of populations worldwide, problems ranging from the accumulation of deficits and chronic diseases, to polypharmacy malnutrition and the loss of function and independence are growing. In all the aforementioned, skeletal muscle plays a central role. Recent decades have shown an increase in the interest of researchers and clinicians in muscular physiology and pathophysiology. It has been demonstrated that sarcopenia is linked, on one hand, to low-grade inflammation, and on the other hand, to an increased risk of clinical complications including increased cardiovascular risk and increased risk of fatal events. On the functional plane, muscular insufficiency is related to frailty syndrome and dependence, and has a bidirectional association with nutrition. This broad spectrum of important interrelations makes it necessary to fill in all possible existing knowledge gaps. From the basic science side, the process of ageing of the muscle still needs better elucidation, especially when the role of mitochondria in the process is concerned. The role of nutrition (from nutritional assessment through interactions between foodstuffs and physiology of the skeletal muscle, to nutritional intervention) is of paramount importance, especially in the view of the epidemic of obese sarcopenia in older persons. This brings up the issue of translational aspects, integrating the advances in our understanding of physiology and pathophysiology of the muscle tissue with the clinically relevant actions, that might improve the muscle mass, architecture, and function, and thus, benefit our patients. To this end, together with Nutrients, we are glad to open up the submission process to this Special Issue dedicated to muscular health.

Prof. Dr. Jerzy Gasowski
Dr. Karolina Piotrowicz
Guest Editors

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Keywords

  • skeletal muscle
  • sarcopenia
  • nutritional intervention
  • older persons
  • muscle Injuries
  • muscular health

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Published Papers (3 papers)

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Research

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12 pages, 959 KiB  
Article
Association of Spinal Alignment and Abdominal Circumference with Sarcopenia Status and Fall Risk in Patients with Osteoporosis: A Retrospective Study
by Takashi Nagai, Makoto Miyagami, Ichiro Okano, Shota Nakamura, Yuichiro Okazaki, Keizo Sakamoto, Fumihito Kasai, Yoshifumi Kudo and Nobuyuki Kawate
Nutrients 2023, 15(11), 2571; https://doi.org/10.3390/nu15112571 - 31 May 2023
Cited by 3 | Viewed by 1992
Abstract
Since vertebral kyphosis and abdominal circumference are thought to influence sarcopenia and fall risk in osteoporosis, we evaluated sarcopenia and fall risk in patients with different measurements of abdominal circumference and sagittal longitudinal axis (SVA). In this post hoc study, 227 patients aged [...] Read more.
Since vertebral kyphosis and abdominal circumference are thought to influence sarcopenia and fall risk in osteoporosis, we evaluated sarcopenia and fall risk in patients with different measurements of abdominal circumference and sagittal longitudinal axis (SVA). In this post hoc study, 227 patients aged 65 years or more who visited an outpatient osteoporosis clinic were included in the analysis. Sarcopenia was determined from lean body mass, grip strength, and walking speed by dual energy X-ray absorptiometry; SVA (median 40 mm) and abdominal circumference (median 80 cm) were compared between the four groups, each divided into two groups. Nutritional management, falls, and fall anxiety scores were also examined. The incidence of sarcopenia was significantly increased in those with abdominal circumference < 80 cm in both the SVA < 40 mm and SVA ≥ 40 mm groups (p < 0.05). Nonetheless, the fall scores of those with SVA < 40 mm were lower than those of individuals with SVA ≥ 40 mm (p < 0.01). Based on the results of this study, SVA and abdominal circumference values may predict the risk of sarcopenia and falls. More research is needed before our results can be translated into clinical practice. Full article
(This article belongs to the Special Issue Nutritional Strategies for Diseases Associated with Muscle Injuries)
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Review

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24 pages, 1798 KiB  
Review
New Trends to Treat Muscular Atrophy: A Systematic Review of Epicatechin
by Iris Jasmin Santos German, Karina Torres Pomini, Jesus Carlos Andreo, João Vitor Tadashi Cosin Shindo, Marcela Vialogo Marques de Castro, Claudia Rucco P. Detregiachi, Adriano Cressoni Araújo, Elen Landgraf Guiguer, Lucas Fornari Laurindo, Patrícia Cincotto dos Santos Bueno, Maricelma da Silva Soares de Souza, Marcia Gabaldi, Sandra Maria Barbalho and André Luis Shinohara
Nutrients 2024, 16(2), 326; https://doi.org/10.3390/nu16020326 - 22 Jan 2024
Cited by 3 | Viewed by 6048
Abstract
Epicatechin is a polyphenol compound that promotes skeletal muscle differentiation and counteracts the pathways that participate in the degradation of proteins. Several studies present contradictory results of treatment protocols and therapeutic effects. Therefore, the objective of this systematic review was to investigate the [...] Read more.
Epicatechin is a polyphenol compound that promotes skeletal muscle differentiation and counteracts the pathways that participate in the degradation of proteins. Several studies present contradictory results of treatment protocols and therapeutic effects. Therefore, the objective of this systematic review was to investigate the current literature showing the molecular mechanism and clinical protocol of epicatechin in muscle atrophy in humans, animals, and myoblast cell-line. The search was conducted in Embase, PubMed/MEDLINE, Cochrane Library, and Web of Science. The qualitative analysis demonstrated that there is a commonness of epicatechin inhibitory action in myostatin expression and atrogenes MAFbx, FOXO, and MuRF1. Epicatechin showed positive effects on follistatin and on the stimulation of factors related to the myogenic actions (MyoD, Myf5, and myogenin). Furthermore, the literature also showed that epicatechin can interfere with mitochondrias’ biosynthesis in muscle fibers, stimulation of the signaling pathways of AKT/mTOR protein production, and amelioration of skeletal musculature performance, particularly when combined with physical exercise. Epicatechin can, for these reasons, exhibit clinical applicability due to the beneficial results under conditions that negatively affect the skeletal musculature. However, there is no protocol standardization or enough clinical evidence to draw more specific conclusions on its therapeutic implementation. Full article
(This article belongs to the Special Issue Nutritional Strategies for Diseases Associated with Muscle Injuries)
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12 pages, 548 KiB  
Review
Poor Appetite in Frail Older Persons—A Systematic Review
by Anna Rudzińska, Karolina Piotrowicz, Ian Perera, Barbara Gryglewska and Jerzy Gąsowski
Nutrients 2023, 15(13), 2966; https://doi.org/10.3390/nu15132966 - 29 Jun 2023
Cited by 4 | Viewed by 3933
Abstract
Anorexia of aging is a common problem in older adults. Depending on the setting, its prevalence varies from about 10% (among community-dwelling older adults) to over 30% in acute wards and nursing homes. The objective of this systematic review was to establish the [...] Read more.
Anorexia of aging is a common problem in older adults. Depending on the setting, its prevalence varies from about 10% (among community-dwelling older adults) to over 30% in acute wards and nursing homes. The objective of this systematic review was to establish the prevalence of poor appetite in frail persons ≥60 years of age. We performed a literature search for studies where the prevalence of anorexia of aging among frail and pre-frail old adults was reported. 957 articles on this topic were identified. After eligibility assessment, three articles were included in the review. The studies included 4657 community-dwelling older adults. The weighted total prevalence of anorexia of aging in all the included studies was 11.3%. Among frail and pre-frail participants, loss of appetite was reported in 20.5% (weighted estimate). Overall, robust status was associated with a 63% lower probability of concomitant anorexia of ageing (OR 0.37, 95%CI 0.21–0.65, p = 0.0005). Frailty or risk of frailty are associated with more prevalent anorexia of ageing. This has potential practical implications; however, more research, especially to elucidate the direction of the relation, is needed. Full article
(This article belongs to the Special Issue Nutritional Strategies for Diseases Associated with Muscle Injuries)
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