nutrients-logo

Journal Browser

Journal Browser

The Impact of Lipids in Cancer

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Lipids".

Deadline for manuscript submissions: closed (5 February 2024) | Viewed by 547

Special Issue Editor


E-Mail Website
Guest Editor
Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA
Interests: cancer; lipids; disparity; pathology; molecular biology; ultrastructure

Special Issue Information

Dear Colleagues,

Lipids such as fatty acids, cholesterol, phospholipids, etc., are critical for human nutrition and health. In addition to serving as cellular building blocks and a primary source of energy, lipids play an important role in the development and progression of cancers. The determination of lipid metabolism in synthesis, storage and uptake could help to elucidate the mechanisms underlying oncogenesis, to prevent occurrence and progression of malignancies, and discover novel therapeutic targets in the treatment of cancers.

This planned Special Issue will focus on lipids in the pathogenesis, prevention and treatment of cancers. Original investigations and reviews are welcome. This Special Issue will include manuscripts detailing the impact of lipids on cancers and human nutrition and health in the form of clinical studies, in vitro and in vivo studies. Manuscripts involving the roles of therapeutic drugs that target lipid metabolism in the treatment of cancers are especially encouraged.

Dr. Xinchun Zhou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • lipids
  • pathogenesis
  • progression
  • prevention
  • treatment
  • dietary fats and oils
  • omega-3 fatty acids

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

16 pages, 15616 KiB  
Article
Influence of Dietary Polyunsaturated Fatty Acid Intake on Potential Lipid Metabolite Diagnostic Markers in Renal Cell Carcinoma: A Case-Control Study
by Yeon-Hee Kim, Jin-Soo Chung, Hyung-Ho Lee, Jin-Hee Park and Mi-Kyung Kim
Nutrients 2024, 16(9), 1265; https://doi.org/10.3390/nu16091265 - 24 Apr 2024
Viewed by 377
Abstract
Non-invasive diagnostics are crucial for the timely detection of renal cell carcinoma (RCC), significantly improving survival rates. Despite advancements, specific lipid markers for RCC remain unidentified. We aimed to discover and validate potent plasma markers and their association with dietary fats. Using lipid [...] Read more.
Non-invasive diagnostics are crucial for the timely detection of renal cell carcinoma (RCC), significantly improving survival rates. Despite advancements, specific lipid markers for RCC remain unidentified. We aimed to discover and validate potent plasma markers and their association with dietary fats. Using lipid metabolite quantification, machine-learning algorithms, and marker validation, we identified RCC diagnostic markers in studies involving 60 RCC and 167 healthy controls (HC), as well as 27 RCC and 74 HC, by analyzing their correlation with dietary fats. RCC was associated with altered metabolism in amino acids, glycerophospholipids, and glutathione. We validated seven markers (l-tryptophan, various lysophosphatidylcholines [LysoPCs], decanoylcarnitine, and l-glutamic acid), achieving a 96.9% AUC, effectively distinguishing RCC from HC. Decreased decanoylcarnitine, due to reduced carnitine palmitoyltransferase 1 (CPT1) activity, was identified as affecting RCC risk. High intake of polyunsaturated fatty acids (PUFAs) was negatively correlated with LysoPC (18:1) and LysoPC (18:2), influencing RCC risk. We validated seven potential markers for RCC diagnosis, highlighting the influence of high PUFA intake on LysoPC levels and its impact on RCC occurrence via CPT1 downregulation. These insights support the efficient and accurate diagnosis of RCC, thereby facilitating risk mitigation and improving patient outcomes. Full article
(This article belongs to the Special Issue The Impact of Lipids in Cancer)
Show Figures

Graphical abstract

Back to TopTop