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Probiotics and Homeostasis: How Probiotics Interact with Digestive Systems to Participate in Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Prebiotics and Probiotics".

Deadline for manuscript submissions: closed (15 February 2024) | Viewed by 1342

Special Issue Editors

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310058, China
Interests: nanomedicine; phytomedicine; probiotics; bioactivity
Special Issues, Collections and Topics in MDPI journals
Tea Research Institute, Zhejiang University, Hangzhou 310058, China
Interests: food chemistry; food functional factors; polyphenols; polysaccharides; tea compound
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the versatile bioactivities and molecular mechanisms of probiotics and their metabolites. Probiotics and their metabolites can interact with various gastrointestinal components (from oral cavity, stomach, gut, etc.) to maintain physiological homeostasis, including intestinal microenvironment regulation, gut microbiota interference, biological barrier formation, epithelial cell metabolism intervention, and so on. In addition, probiotics and their metabolites also exert diverse bioactivities to participate in diseases pathogenesis, development and prognosis, directly or via various “digestive system–organs” axes; these include anti-inflammation, anti-oxidation, anti-obesity, hypoglycemic and anti-tumor activities, among others. Moreover, probiotics/metabolites also interact with food digests to play a crucial role in nutrition, digestion, absorption and metabolism. Revealing the efficacy and corresponding interactions between probiotics/metabolites with gastrointestinal components will promote the comprehensive understanding of this topic, the development of innovative strategies and the advancement of promising applications for future probiotics-mediated health interventions. Original research articles, short communications, and reviews are all welcome in this Special Issue.

We look forward to receiving your contributions!

Dr. Yonglu Li
Dr. Qiang Chu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • probiotics
  • metabolites
  • homeostasis
  • interactions

Published Papers (1 paper)

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Research

14 pages, 1993 KiB  
Article
Investigating the Metabolism of Estrogens in Ligilactobacillus salivarius Strains Isolated from Human Milk and Vaginal Microbiota
by Alberto Aragón, Rubén Jurado, Josué Jara, Juan Miguel Rodríguez and Belén Orgaz
Nutrients 2024, 16(6), 861; https://doi.org/10.3390/nu16060861 - 16 Mar 2024
Viewed by 1137
Abstract
The interplay between enterohepatic circulation and the gut microbiota is the main driver determining systemic levels of estrogens and their metabolites. Nevertheless, the role of potentially probiotic microorganisms in estrogen metabolism has not been investigated so far. In this work, we have explored [...] Read more.
The interplay between enterohepatic circulation and the gut microbiota is the main driver determining systemic levels of estrogens and their metabolites. Nevertheless, the role of potentially probiotic microorganisms in estrogen metabolism has not been investigated so far. In this work, we have explored the ability of six Ligilactobacillus salivarius strains isolated from human milk and vaginal samples to degrade and/or conjugate parental estrogens in vitro and under aerobic conditions. The quantification of estrogens and their derivatives was carried out in cell-free supernatants by LC-QQQ-MS. All the tested L. salivarius strains achieved an average degradation rate of estrone and estriol of 98% and 55%, respectively, whereas 17β-estradiol was preferentially conjugated (up to 40%). The presence of seven out of ten genes encoding enzymes relevant for estrogen metabolism was further confirmed by PCR, highlighting their genetic potential for degrading, conjugating and/or deconjugating estrogens. The tested L. salivarius strains may be considered potential probiotics affecting the fate of endogenous estrogens. Clinical trials targeting populations with estrogen-dependent conditions will be required to elucidate the true potential of these strains for the restoration and maintenance of a healthy host estrobolome. Full article
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