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Glycemic Control and Weight Management among Patients with Type 1...
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Glycemic Control and Weight Management among Patients with Type 1 Diabetes

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Diabetes".

Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 5761

Special Issue Editor

Dr. Annalisa Blasetti

E-Mail Website
Guest Editor
Department of Paediatrics, University of Chieti, Via dei Vestini, 5, IT-66100 Chieti, Italy
Interests: type 1 diabetes; children and adolescents; insulin resistance; glycemic control; lipid profile; dietary management

Special Issue Information

Dear Colleagues,

Type 1 diabetes (T1D) is one of the most common chronic autoimmune disease during childhood, accounting for about 5–10% of all diabetes forms. In the last several decades, the incidence of the disease has increased in many countries, with an estimated overall annual increase at around 3%, with geographic differences. Early weight gain in infancy, high nutrient intake and large body size in childhood have been associated with type 1 diabetes. It has also been suggested that childhood weight gain accounts for the trend towards an earlier age at onset observed in type 1 diabetes. This Special Issue will address the role of the dietary management of type 1 diabetes in children and adolescents, not only regarding glycemic control, but also considering the influence of dietary habits on age at onset of type 1 diabetes (the so called “accelerator hypothesis”) and its role on preserving residual beta cell secretion.

Finally, the Special Issue will also focus on the influence of diet for cardiovascular risk prevention in type 1 diabetes.

Dr. Annalisa Blasetti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • type 1 diabetes
  • children and adolescents
  • insulin resistance
  • glycemic control
  • lipid profile
  • dietary management

Published Papers (2 papers)

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Research

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16 pages, 1795 KiB  
Article
Serum Metabolomics Reveals a Potential Benefit of Methionine in Type 1 Diabetes Patients with Poor Glycemic Control and High Glycemic Variability
by Liyin Zhang, Keyu Guo, Qi Tian, Jianan Ye, Zhiyi Ding, Qin Zhou, Xia Li, Zhiguang Zhou and Lin Yang
Nutrients 2023, 15(3), 518; https://doi.org/10.3390/nu15030518 - 19 Jan 2023
Cited by 5 | Viewed by 2347
Abstract
Glycemic variability (GV) in some patients with type 1 diabetes (T1D) remains heterogeneous despite comparable clinical indicators, and whether other factors are involved is yet unknown. Metabolites in the serum indicate a broad effect of GV on cellular metabolism and therefore are more [...] Read more.
Glycemic variability (GV) in some patients with type 1 diabetes (T1D) remains heterogeneous despite comparable clinical indicators, and whether other factors are involved is yet unknown. Metabolites in the serum indicate a broad effect of GV on cellular metabolism and therefore are more likely to indicate metabolic dysregulation associated with T1D. To compare the metabolomic profiles between high GV (GV-H, coefficient of variation (CV) of glucose ≥ 36%) and low GV (GV-L, CV < 36%) groups and to identify potential GV biomarkers, metabolomics profiling was carried out on serum samples from 17 patients with high GV, 16 matched (for age, sex, body mass index (BMI), diabetes duration, insulin dose, glycated hemoglobin (HbA1c), fasting, and 2 h postprandial C-peptide) patients with low GV (exploratory set), and another 21 (GV-H/GV-L: 11/10) matched patients (validation set). Subsequently, 25 metabolites were significantly enriched in seven Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways between the GV-H and GV-L groups in the exploratory set. Only the differences in spermidine, L-methionine, and trehalose remained significant after validation. The area under the curve of these three metabolites combined in distinguishing GV-H from GV-L was 0.952 and 0.918 in the exploratory and validation sets, respectively. L-methionine was significantly inversely related to HbA1c and glucose CV, while spermidine was significantly positively associated with glucose CV. Differences in trehalose were not as reliable as those in spermidine and L-methionine because of the relatively low amounts of trehalose and the inconsistent fold change sizes in the exploratory and validation sets. Our findings suggest that metabolomic disturbances may impact the GV of T1D. Additional in vitro and in vivo mechanistic studies are required to elucidate the relationship between spermidine and L-methionine levels and GV in T1D patients with different geographical and nutritional backgrounds. Full article
(This article belongs to the Special Issue Glycemic Control and Weight Management among Patients with Type 1 Diabetes)
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Review

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12 pages, 730 KiB  
Review
Role of Prenatal Nutrition in the Development of Insulin Resistance in Children
by Annalisa Blasetti, Alessia Quarta, Miriana Guarino, Ilenia Cicolini, Daniela Iannucci, Cosimo Giannini and Francesco Chiarelli
Nutrients 2023, 15(1), 87; https://doi.org/10.3390/nu15010087 - 24 Dec 2022
Cited by 3 | Viewed by 3019
Abstract
Nutrition during the prenatal period is crucial for the development of insulin resistance (IR) and its consequences in children. The relationship between intrauterine environment, fetal nutrition and the onset of IR, type 2 diabetes (T2D), obesity and metabolic syndrome later in life has [...] Read more.
Nutrition during the prenatal period is crucial for the development of insulin resistance (IR) and its consequences in children. The relationship between intrauterine environment, fetal nutrition and the onset of IR, type 2 diabetes (T2D), obesity and metabolic syndrome later in life has been confirmed in many studies. The intake of carbohydrates, protein, fat and micronutrients during pregnancy seems to damage fetal metabolism programming; indeed, epigenetic mechanisms change glucose−insulin metabolism. Intrauterine growth restriction (IUGR) induced by unbalanced nutrient intake during prenatal life cause fetal adipose tissue and pancreatic beta-cell dysfunction. In this review we have summarized and discussed the role of maternal nutrition in preventing insulin resistance in youth. Full article
(This article belongs to the Special Issue Glycemic Control and Weight Management among Patients with Type 1 Diabetes)
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