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Dietary Nutrition for Neurological Disease Therapy: Current Status and Future Directions

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: closed (20 January 2023) | Viewed by 11832

Special Issue Editors


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Guest Editor
Department of Neurology and Clinical Neuroscience Center, Prague, Czech Republic
Interests: neurologist; physician nutrition specialist—neurodegenerative disorders; malnutrition in neurology

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Guest Editor
General University Hospital in Prague, Prague, Czech Republic
Interests: internist; intensivist; physician nutrition specialist—disease-related malnutrition; nutrition support in critically ill; home enteral and parenteral nutrition

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Guest Editor
3rd Medical Faculty Charles University and Teaching Thomayer Hospital, Prague, Czech Republic
Interests: gastroenterologist; gut microbiota; physician nutrition specialist—metabolic ICU; enteral and parenteral nutrition, including HPN and HEN; malnutrition

Special Issue Information

Dear Colleagues,

Nutritional disorders occur in neurological patients for a variety of reasons. Patients with stroke are particularly at risk of acute malnutrition and dysphagia, while those with neurodegenerative diseases are also at risk of chronic malnutrition and swallowing disturbances. All these patients may have a range of movement, behavioral, and cognitive impairments. These combined deficits make it difficult or even impossible to prepare and consume food independently. They also increase the body's energy requirements, potentiate the loss of functional muscle mass, and lead to economic and social insecurity. Neurogenic dysphagia, including associated respiratory and nutritional disorders such as aspiration, suffocation, pneumonia, malnutrition, and dehydration, threaten patient outcomes. Low body-mass index, non-volitional weight-loss and sarcopenia at the onset of neurodegenerative diseases are considered negative prognostic markers. Early nutritional, physiotherapeutic, and psychotherapeutic interventions, which require interdisciplinary cooperation, reduce the incidence of complications and improve patients’ quality of life.

Dr. Jiří Klempíř
Dr. František Novák
Dr. Pavel Kohout
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • malnutrition in neurology
  • dysphagia
  • stroke
  • epilepsy
  • neurodegenerative disorders
  • dementia
  • percutaneous gastrostomy
  • sarcopenia
  • spinal cord injury

Published Papers (2 papers)

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Research

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16 pages, 1418 KiB  
Article
Impact of Nutritional Status on Outcomes of Stroke Survivors: A Post Hoc Analysis of the NHANES
by Hsueh-Yi Lu, Ue-Cheung Ho and Lu-Ting Kuo
Nutrients 2023, 15(2), 294; https://doi.org/10.3390/nu15020294 - 6 Jan 2023
Cited by 2 | Viewed by 3740
Abstract
Stroke, a neurological emergency, is a leading cause of death and disability in adults worldwide. In acute or rehabilitative stages, stroke survivors sustain variable neurological recovery with long-term disabilities. The influence of post-stroke nutritional status on long-term survival has not been confirmed. Using [...] Read more.
Stroke, a neurological emergency, is a leading cause of death and disability in adults worldwide. In acute or rehabilitative stages, stroke survivors sustain variable neurological recovery with long-term disabilities. The influence of post-stroke nutritional status on long-term survival has not been confirmed. Using the United States National Health and Nutrition Examination Survey data (2001–2010), we conducted a matched-cohort analysis (929 and 1858 participants in stroke and non-stroke groups, respectively) to investigate the influence of nutritional elements on post-stroke survival. With significantly lower nutrient consumption, the mortality risk was 2.2 times higher in stroke patients compared to non-stroke patients (Kaplan–Meier method with Cox proportional hazards model: adjusted hazard ratio, 2.208; 95% confidence interval: 1.887–2.583; p < 0.001). For several nutritional elements, the lower consumption group had significantly shorter survival than the higher consumption stroke subgroup; moreover, stroke patients with the highest 25% nutritional intake for each nutritional element, except moisture and total fat, had significantly shorter survival than non-stroke patients with the lowest 25% nutrition. Malnutrition is highly prevalent in stroke patients and is associated with high mortality rates. The dynamic change in energy requirements throughout the disease course necessitates dietary adjustment to ensure adequate nutritional intake. Full article
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Review

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18 pages, 347 KiB  
Review
The Role of Micronutrients in Neurological Disorders
by Helena Lahoda Brodska, Jiri Klempir, Jan Zavora and Pavel Kohout
Nutrients 2023, 15(19), 4129; https://doi.org/10.3390/nu15194129 - 25 Sep 2023
Cited by 1 | Viewed by 7555
Abstract
Trace elements and vitamins, collectively known as micronutrients, are essential for basic metabolic reactions in the human body. Their deficiency or, on the contrary, an increased amount can lead to serious disorders. Research in recent years has shown that long-term abnormal levels of [...] Read more.
Trace elements and vitamins, collectively known as micronutrients, are essential for basic metabolic reactions in the human body. Their deficiency or, on the contrary, an increased amount can lead to serious disorders. Research in recent years has shown that long-term abnormal levels of micronutrients may be involved in the etiopathogenesis of some neurological diseases. Acute and chronic alterations in micronutrient levels may cause other serious complications in neurological diseases. Our aim was to summarize the knowledge about micronutrients in relation to selected neurological diseases and comment on their importance and the possibilities of therapeutic intervention in clinical practice. Full article
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