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Food Fortification: Trends and Strategies

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 28193

Special Issue Editor

HarvestPlus, International Food Policy Research Institute, Washington, DC, USA
Interests: applicable human nutrition research that translates into lower malnutrition and preventable disease; bioavailability and efficacy trials testing food-based alternatives to alleviate hidden hunger; the role of micronutrients and phytochemicals on NCD prevention

Special Issue Information

Dear colleagues,

Food fortification is a public health nutrition intervention with proven effectiveness for the prevention and reduction of micronutrient deficiencies and the promotion of good health. However, scaling up this and other important nutrition interventions has not addressed global inequalities in health, and micronutrient malnutrition among women and children—although preventable—remains unacceptably high. A concurrent pandemic of obesity and diet-related noncommunicable diseases alongside an accelerating and unabated climate crisis raises questions about the role of mass food fortification in moderating the production and consumption of highly processed, nutrient-poor foods and mitigating the double burden of disease.

Numerous publications have summarized the important progress attained through the mass fortification of highly processed cereals, vegetable oils, and condiments in preventing micronutrient deficiencies and curbing their coincident burden of disease. Though dietary diversity remains the ideal solution to improve nutrition, staple-food-based approaches are more cost-effective. However, reform of industry, policy, and program practice is required for food fortification to make an urgently needed contribution to a food system transformation that balances the promotion of whole-grain flours and healthier legume-cereal flour alternatives with the moderation of cooking oil, salt, and sugar consumption, and the active rejection of obesogenic and non-health-promoting foods.

Focus of this Special Issue of Nutrients:

This series of papers will critically consider and describe the advantages and disadvantages of mass food fortification relative to the double burden of disease, as well as opportunities for its contribution to food systems transformation. It will discuss emerging or opportunistic trends in food fortification, note unanswered questions for future research, and highlight drivers of successful and sustainable program implementation to safeguard health and shift the global population closer towards the universal goal of ending hidden hunger without increasing overt excess.

Dr. Erick Boy
Guest Editor

Manuscript Submission Information

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Keywords

  • food fortification
  • public health
  • micronutrient malnutrition
  • maternal and child health
  • monitoring
  • food industry
  • food systems
  • non-communicable disease
  • ultra-processed foods

Published Papers (8 papers)

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Research

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16 pages, 1408 KiB  
Article
Role of Nutrition Information in Acceptance and Willingness to Pay for Biofortified Cereal Food: Implications for Better Health and Sustainable Diet
by Muhammad Rizwan, Azhar Abbas, Hui Xu, Umar Ijaz Ahmed, Ping Qing, Puming He, Muhammad Amjed Iqbal and Muhammad Aamir Shahzad
Nutrients 2022, 14(16), 3352; https://doi.org/10.3390/nu14163352 - 16 Aug 2022
Cited by 2 | Viewed by 2500
Abstract
A range of nutritional needs are met through the use of fortified farm-based foods. Wheat biorfortification with zinc is such an example where biorfortification is carried out for a crucial element like Zinc. Zinc-biofortified wheat (Zn-wheat) has been officially launched in Pakistan since [...] Read more.
A range of nutritional needs are met through the use of fortified farm-based foods. Wheat biorfortification with zinc is such an example where biorfortification is carried out for a crucial element like Zinc. Zinc-biofortified wheat (Zn-wheat) has been officially launched in Pakistan since 2016 but its wide-scale dissemination, adoption and consumption have not taken place till to date. On the other hand, essential nutrients deficiencies have wide-ranging implications for public health especially for children and lactating mothers. This study is undertaken to know the reasons for the slow progression of scaling up of biofortified wheat varieties in Pakistan, people’s awareness about biofortified wheat and to recognize the role of information in acceptance and willingness to pay for this wheat. For this purpose, randomly selected 474 households were interviewed from four districts of Punjab province. They were categorized into four groups based on their exposure to information in real and hypothetical cheap talk (game theory context). Study findings reveal that respondents were ready to pay for fortified wheat if they are aware about nutrient aspects and Zn deficiency. Using Discrete Choice Experiment, the preferences for and factors affecting the willingness to pay for fortified wheat are evaluated. Main factors having positive impact include household head’s education and income, having pregnant women and children <5 years age. It was also found that people having valid information about nutrients of a food would be willing to pay more. The study highlights need for policy focus on educating people about nutritional aspects as well as making available biofortified foods to promote healthy living. Full article
(This article belongs to the Special Issue Food Fortification: Trends and Strategies)
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16 pages, 752 KiB  
Article
Effect of Dietary Fiber (Oat Bran) Supplement in Heart Rate Lowering in Patients with Hypertension: A Randomized DASH-Diet-Controlled Clinical Trial
by Yang Ju, Chenglin Zhang, Zhirong Zhang, Hongying Zhu, Yuanyuan Liu, Ting Liu, Omorogieva Ojo, Jingbo Qiu and Xiaohua Wang
Nutrients 2022, 14(15), 3148; https://doi.org/10.3390/nu14153148 - 30 Jul 2022
Cited by 4 | Viewed by 3579
Abstract
(1) Background: The management goal for patients with essential hypertension (HTN) is not only to lower blood pressure (BP), but also to control increased heart rate (HR). In a previous study, it was found that dietary fiber (DF) supplementation can effectively reduce BP [...] Read more.
(1) Background: The management goal for patients with essential hypertension (HTN) is not only to lower blood pressure (BP), but also to control increased heart rate (HR). In a previous study, it was found that dietary fiber (DF) supplementation can effectively reduce BP in patients with HTN. The aim of this study was to determine whether a DF supplement can lower HR in patients with HTN. (2) Methods: Seventy patients who met the inclusion and exclusion criteria were randomly allocated into the control group (n = 34) and the intervention group (n = 36). The regular DASH dietary care was delivered to both groups of patients. In addition, one bag of oat bran (30 g/d, containing DF 8.9 g) was delivered to the intervention group. The 24 h ambulatory heart rate was measured at baseline and 3 months. (3) Results: At 3 months, the 24 h maximum heart rate (24h maxHR) in the intervention group was significantly lower than that in the control group. After the intervention, within-group comparisons in the intervention group revealed that there were significant reductions in the 24 h average heart rate (24h aveHR), 24h maxHR, average heart rate during day time (D-aveHR), minimum heart rate during day time (D-minHR), and maximum heart rate during day time (D-maxHR). Similar differences were not found in the control group. (4) Conclusions: Dietary fiber (oat bran) supplementation might be beneficial in lowering HR in patients with HTN. Full article
(This article belongs to the Special Issue Food Fortification: Trends and Strategies)
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13 pages, 853 KiB  
Article
The Role of Multiply-Fortified Table Salt and Bouillon in Food Systems Transformation
by Dipika Matthias, Christine M. McDonald, Nicholas Archer and Reina Engle-Stone
Nutrients 2022, 14(5), 989; https://doi.org/10.3390/nu14050989 - 26 Feb 2022
Cited by 11 | Viewed by 3001
Abstract
Our global food system lacks the critically needed micronutrients to meet the daily requirements of the most at-risk populations. Diets also continue to shift toward unhealthy foods, including the increased intake of salt. While most countries exceed the WHO’s recommended levels, sodium does [...] Read more.
Our global food system lacks the critically needed micronutrients to meet the daily requirements of the most at-risk populations. Diets also continue to shift toward unhealthy foods, including the increased intake of salt. While most countries exceed the WHO’s recommended levels, sodium does play an essential physiological role. Table salt and other salt-containing condiments, such as bouillon, also have cultural importance, as they are used to enhance the flavor of foods cooked at home. Given their universal consumption across income classes and both urban and rural populations, these condiments are an integral part of the food system and should, therefore, be part of its transformation. Fortification of salt and salt-containing condiments can play a catalytic role in the delivery of population-wide nutritional and health benefits. With relatively consistent levels of intake across the population, these condiments hold high potential for delivering micronutrients beyond iodine while also reducing concerns related to high micronutrient intake, particularly so in countries where the industries are relatively consolidated. As a flexible and complementary strategy to an evolving food system, fortification levels can also be adjusted over time to ensure micronutrient delivery targets continue to be achieved as the system improves, whether through lower intakes of sodium in line with WHO recommendations, enhanced consumption of nutrient-dense foods, and/or broader adoption of biofortified crops. Future areas of innovation are required to realize this vision, including developing affordable salt substitutes to meet cost requirements of consumers in low-and middle-income countries, improving the stability and bioavailability of the micronutrients in condiments so that delivery targets can be reached without affecting sensory attributes, and the development of efficient systems for monitoring population intake and micronutrient status to inform fortification program design and management. Rather than being considered antithetical to the transformation, multiply-fortified salt and bouillon can strengthen our ability to meet the cultural, sensory, nutritional, and health needs of an evolving food system. Full article
(This article belongs to the Special Issue Food Fortification: Trends and Strategies)
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Review

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16 pages, 561 KiB  
Review
Zinc Fortification: Current Trends and Strategies
by Andrew G. Hall and Janet C. King
Nutrients 2022, 14(19), 3895; https://doi.org/10.3390/nu14193895 - 21 Sep 2022
Cited by 17 | Viewed by 3660
Abstract
Zinc, through its structural and cofactor roles, affects a broad range of critical physiological functions, including growth, metabolism, immune and neurological functions. Zinc deficiency is widespread among populations around the world, and it may, therefore, underlie much of the global burden of malnutrition. [...] Read more.
Zinc, through its structural and cofactor roles, affects a broad range of critical physiological functions, including growth, metabolism, immune and neurological functions. Zinc deficiency is widespread among populations around the world, and it may, therefore, underlie much of the global burden of malnutrition. Current zinc fortification strategies include biofortification and fortification with zinc salts with a primary focus on staple foods, such as wheat or rice and their products. However, zinc fortification presents unique challenges. Due to the influences of phytate and protein on zinc absorption, successful zinc fortification strategies should consider the impact on zinc bioavailability in the whole diet. When zinc is absorbed with food, shifts in plasma zinc concentrations are minor. However, co-absorbing zinc with food may preferentially direct zinc to cellular compartments where zinc-dependent metabolic processes primarily occur. Although the current lack of sensitive biomarkers of zinc nutritional status reduces the capacity to assess the impact of fortifying foods with zinc, new approaches for assessing zinc utilization are increasing. In this article, we review the tools available for assessing bioavailable zinc, approaches for evaluating the zinc nutritional status of populations consuming zinc fortified foods, and recent trends in fortification strategies to increase zinc absorption. Full article
(This article belongs to the Special Issue Food Fortification: Trends and Strategies)
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15 pages, 908 KiB  
Review
Small and Medium Enterprises’ Perspectives on Food Fortification Amid the Growing Burden of Malnutrition
by Jimena Monroy-Gomez, Chiara Ferraboschi, Kesso Gabrielle van Zutphen, Breda Gavin-Smith, Daniel Amanquah and Klaus Kraemer
Nutrients 2022, 14(18), 3837; https://doi.org/10.3390/nu14183837 - 16 Sep 2022
Cited by 6 | Viewed by 3429
Abstract
The need for a profound food system transformation has never been greater. The growing burden of malnutrition has become the new normal, with two billion people who are overweight, over 140 million children under five who are stunted and over two billion people [...] Read more.
The need for a profound food system transformation has never been greater. The growing burden of malnutrition has become the new normal, with two billion people who are overweight, over 140 million children under five who are stunted and over two billion people affected by hidden hunger. Food fortification has been recognized as a cost-effective strategy to address micronutrient deficiencies. Small and medium enterprises (SMEs) play a strategic role in the food supply chain in low- and middle-income countries, accounting for over 80% of food sales. It is therefore critical to create an enabling environment to facilitate SMEs’ involvement in food fortification practices as a potential solution to tackle all forms of malnutrition. This review highlights SMEs’ relevance as agents of change in the food system through food fortification practices and their indirect yet key role in producing nutritious, tasty and affordable foods. It discusses their challenges (e.g., access to long-term finance, sustainable technical assistance, limited capacity), presents solutions and discusses how different actors can help SMEs to overcome these challenges. Furthermore, it presents a relevant public–private partnership case study to demonstrate how SMEs can address the growing burden of malnutrition through food fortification practices, nutrient profiling schemes and demand generation. Full article
(This article belongs to the Special Issue Food Fortification: Trends and Strategies)
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19 pages, 332 KiB  
Review
Ensuring the Efficacious Iron Fortification of Foods: A Tale of Two Barriers
by Richard F. Hurrell
Nutrients 2022, 14(8), 1609; https://doi.org/10.3390/nu14081609 - 12 Apr 2022
Cited by 17 | Viewed by 4477
Abstract
Iron fortification of foods has always been a challenge. This is because iron fortification compounds vary widely in relative absorption; because many foods undergo unacceptable changes in color or flavor from the addition of iron; and because many of the iron-fortified foods contain [...] Read more.
Iron fortification of foods has always been a challenge. This is because iron fortification compounds vary widely in relative absorption; because many foods undergo unacceptable changes in color or flavor from the addition of iron; and because many of the iron-fortified foods contain potent inhibitors of iron absorption. These technical barriers have largely been overcome, and efficacious iron-fortified foods, that maintain or improve the iron status of women or children in long-term feeding studies, can be designed. Commercially fortified infant foods are efficacious, and other commercial iron-fortified foods targeted at women and children will provide a useful amount of iron provided the fortification level is adjusted according to the relative absorption of the iron compound. Technologies for the large-scale fortification of wheat and maize flour are also well established, and iron fortification of rice, using the recently developed extruded premix technique, is showing great promise. However, some important knowledge gaps still remain, and further research and development is needed in relation to iron (and iodine)-fortified salt and iron-fortified liquid milk. The usefulness of less-soluble iron compounds, such as ferrous fumarate, to fortify foods for infants and young children in low- and middle-income countries (LMICs) also needs further investigation. A more formidable barrier to efficacious iron-fortified food has been reported in recent years. This is the infection-initiated inflammation barrier, which inhibits iron absorption in response to infection. This barrier is particularly important in LMICs where infections such as malaria and HIV are widespread, and gastrointestinal infections are common due to poor quality water supplies and sanitation. Another source of inflammation in such countries is the high prevalence of obesity in women. Most countries in sub-Saharan Africa have high inflammation which not only decreases the efficacy of iron-fortified and iron-biofortified foods but complicates the monitoring of large-scale iron fortification programs. This is because iron deficiency anemia cannot be differentiated from the more prominent anemia of inflammation and because inflammation confounds the measurement of iron status. There is an urgent need to better quantify the impact of inflammation on the efficacy of iron-fortified foods. However, at present, in LMICs with high inflammation exposure, infection control, cleaner water, improved sanitation, and a decrease in obesity prevalence will undoubtedly have a greater impact on iron status and anemia than the iron fortification of foods. Full article
(This article belongs to the Special Issue Food Fortification: Trends and Strategies)
12 pages, 316 KiB  
Review
Ultraprocessed Products as Food Fortification Alternatives: A Critical Appraisal from Latin America
by Maria F. Kroker-Lobos, Mónica Mazariegos, Mónica Guamuch and Manuel Ramirez-Zea
Nutrients 2022, 14(7), 1413; https://doi.org/10.3390/nu14071413 - 29 Mar 2022
Cited by 9 | Viewed by 3354
Abstract
Ultraprocessed products (UPPs), associated with obesity and non-communicable diseases (NCDs), are becoming predominant on the global market and a target for market-driven fortification initiatives. The aim of this article is to describe the implications of adding micronutrients to UPPs with excessive amounts of [...] Read more.
Ultraprocessed products (UPPs), associated with obesity and non-communicable diseases (NCDs), are becoming predominant on the global market and a target for market-driven fortification initiatives. The aim of this article is to describe the implications of adding micronutrients to UPPs with excessive amounts of critical nutrients associated with NCDs and provide recommendations for legislation and policies. UPPs with added micronutrients such as breakfast cereals, sugar-sweetened beverages, powder beverages, fruit juices, sauces, and bouillon cubes, among others, are commonly available and heavily promoted in Latin American countries. Misleading advertising of UPPs with added micronutrients and with excessive content of sugar, fat, and salt might increase the consumption of such products, giving them a “health halo effect” that leads consumers to overestimate their nutritional quality and healthfulness. Although international collections of standards such as the Codex Alimentarius provide some guidelines on this matter, countries need to implement national legislations, through a food systems approach, to regulate the marketing and labeling of UPPs. Lastly, there is still the need to foster research to close knowledge gaps and help countries to guide the process of food fortification strategies from a regulatory standpoint. Full article
(This article belongs to the Special Issue Food Fortification: Trends and Strategies)

Other

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9 pages, 777 KiB  
Perspective
Aligning the Epidemiology of Malnutrition with Food Fortification: Grasp Versus Reach
by Megan W. Bourassa, Reed Atkin, Jonathan Gorstein and Saskia Osendarp
Nutrients 2023, 15(9), 2021; https://doi.org/10.3390/nu15092021 - 22 Apr 2023
Cited by 2 | Viewed by 1762
Abstract
Large-scale food fortification (LSFF) has been recognized as one of the most cost-effective interventions to improve the intake of vitamins and minerals and decrease the burden of micronutrient deficiency. Indeed, the simple addition of micronutrients to staple foods, such as wheat, maize and [...] Read more.
Large-scale food fortification (LSFF) has been recognized as one of the most cost-effective interventions to improve the intake of vitamins and minerals and decrease the burden of micronutrient deficiency. Indeed, the simple addition of micronutrients to staple foods, such as wheat, maize and rice, or condiments, including salt and bouillon, has tremendous potential to impact malnutrition. However, most LSFF programs have been poorly designed and have not taken into consideration critical inputs, including current levels of nutrient inadequacy and per capita consumption of different food vehicles when deciding which nutrients to add and at what concentrations. LSFF programs, like some other nutrition interventions, also tend to have low coverage and reach and lack monitoring to measure this and course correct. These program design flaws have resulted in limited effectiveness and have made it difficult to determine how best to harmonize LSFF with other interventions to reduce micronutrient deficiencies, including efforts to enhance dietary diversity, biofortification and supplementation. Furthermore, LSFF has often been touted as a population-based intervention, but in fact has heterogenous effects among sub-groups, particularly those with limited access to or inability to afford fortified foods, as well as those with higher physiological requirements, such as pregnant and lactating women. This article focuses on these limitations and the concerted efforts underway to improve the collection, analysis, and use of data to better plan LSFF programs, track implementation, and monitor coverage and impact. This includes a more sophisticated secondary analysis of existing data, innovations to increase the frequency of primary data collection and programmatically relevant visualizations of data of sub-national estimates. These improvements will enable better use of data to target resources and programmatic efforts to reach those who stand to benefit most from fortification. Full article
(This article belongs to the Special Issue Food Fortification: Trends and Strategies)
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